Tag: 100-200

Structural and magnetic behavior of the kinked chain Cu(hfac)₂(tan) and its relevance to Cu(NO₃)₂(tan) (hfac = hexafluoroacetylacetonate; tan = 1,4,5-triazanaphthalene) was written by Manson, Jamie L.. And the article was included in Inorganic Chemistry in 2003.Electric Literature of C7H5N3 This article mentions the following:

When stoichiometric amounts of Cu(hfac)₂·H₂O and 1,4,5-triazanaphthalene (tan) were combined in MeOH, green crystals of Cu(hfac)₂(tan) were formed. Its structure was determined at low temperature (P2₁/c; a 8.3308(4), b 14.8945(7), c 18.3046(10) Å, β 99.298(2)°) and found to consist of a novel kinked-chain arrangement where N atoms on opposite sides of the tan ligand bridge Cu(hfac)₂ moieties together. Long axial Cu-N bonds lead to rather weak (J/k_B = -0.06(5) K) antiferromagnetic interactions according to a Bonner-Fisher fit of the magnetic susceptibility data. The magnetic behavior demonstrated by Cu(hfac)₂(tan) contrasts markedly with that of Cu(NO₃)₂(tan), as reported by Hatfield and co-workers, and is attributed to the differing orientations of the Cu d_x²-y² magnetic orbital. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Electric Literature of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Improved organic hydrogen carriers with superior thermodynamic properties was written by Lu, Rui-Feng;Boethius, Gustav;Wen, Shu-Hao;Su, Yan;Deng, Wei-Qiao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Recommanded Product: 322-46-3 This article mentions the following:

By incorporation of N atoms into naphthalene, we present a theor. investigation to seek improved organic hydrogen carriers with an explicit guideline. The release of H₂ is found to be greatly favored thermodynamically and the corresponding cycloalkanes possess high hydrogen storage capacity. This offers extensive candidates for practical applications of the promising hydrogen energy. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Tris(dipivaloylmethanato)europium-induced shifts of proton resonances in π-deficient nitrogen heterocycles was written by Armarego, W. L. F.;Batterham, T. J.;Kershaw, J. R.. And the article was included in Organic Magnetic Resonance in 1971.Product Details of 322-46-3 This article mentions the following:

Tris(dipivaloylmethanato)europium, [Eu(DPM)3], induced shifts of the PMR of pyridine and its 2-Me, 3-Me, 2,3-di-Me and 2,5-di-Me derivatives, pyridazine, pyrimidine, pyrazine, quinoline, isoquinoline, 1,6-, 1,7- and 1,8-naphthyridine, cinnoline, phthalazine, quinazoline, quinoxaline, 1,4,5- and 1,4,6-triazanaphthalene, pteridine, acridine, phenanthridine and 1,10-phenanthroline, were measured for solutions containing 0.1, 0.3, and 0.5 molar equivalents of Eu(DPM)3. Differences in the behavior of these heterocycles are discussed in terms of the steric relations between the heterocycle and the complex. The 3 cos2 * dhi term, present in the expression for calculating pseudocontact shifts, is important. The order of basicity of these heterocycles, as measured by their pKa values, cannot be used to predict the order of Eu(DPM)3 induced chem. shifts. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Novel coumarin-isatin hybrids as potent antileishmanial agents: Synthesis, in silico and in vitro evaluations was written by Khatoon, Saira;Aroosh, Aiman;Islam, Arshad;Kalsoom, Saima;Ahmad, Faisal;Hameed, Shahid;Abbasi, Sumra Wajid;Yasinzai, Masoom;Naseer, Muhammad Moazzam. And the article was included in Bioorganic Chemistry in 2021.Recommanded Product: Ethyl pyrazine-2-carboxylate This article mentions the following:

The synthesis, in silico, and in vitro evaluations of novel coumarin-incorporated isatin hydrazones I (R = C₆H₅, 4-pyridyl, pyrazin-2-yl, etc.; n = 0, 1) as highly potent and safe antileishmanial agents has been described. Mol. docking was initially carried out to decipher the binding confirmation of lead mols. towards the active cavity of the target protein (Leishmanolysin gp63) of Leishmania tropica. Among all the docked compounds, only I (R = 3-CH₃C₆H₄, 4-H₂NC₆H₄, 4-pyridyl; n = 0) showed high binding affinities due to a pattern of strong conventional hydrogen bonds and hydrophobic π-interactions. The mol. dynamics simulations showed the stable pattern of such bonding and structure-based confirmation with a time scale of 50 ns towards the top compound I (R = 4-pyridyl; n = 0) and protein. These analyses affirmed the high stability of the system. Three out of ten compounds evaluated for their antileishmanial activity against Leishmania tropica promastigotes and amastigotes were found to be active at micromolar concentrations (IC₅₀ range 0.1-4.13μmol/L), and most importantly, they were also found to be highly biocompatible when screened for their toxicity in human erythrocytes. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Recommanded Product: Ethyl pyrazine-2-carboxylate).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Recommanded Product: Ethyl pyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An unexpected replacement of a methyl with an amino in the tetramethylpyrazine system was written by Lang, Ming;Yao, Hui;Fu, Pengfei;Cai, Wei;Wang, Yuqiang;Yu, Pei. And the article was included in Research on Chemical Intermediates in 2015.Computed Properties of C8H12N2O This article mentions the following:

A novel and unexpected product, 5-amino-3,6-dimethyl-2-pyrazinecarbonitrile (3), was obtained during the attempted to synthesis of 3,5,6-trimethyl-2-pyrazinecarbonitrile (2) from its corresponding alc. (1) by the catalytic amount of KI or I₂ in combination with TBHP as an external oxidant. The product was confirmed by ESI-MS, HRMS, ¹H-NMR, ¹³C-NMR, and 2D-NMR. The mechanism for the formation of the amino group in the tetramethylpyrazine system is also proposed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Computed Properties of C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of tetramethylpyrazine derivatives and screening for 5-HT₃ receptor antagonistic activity was written by Jiang, Xiang-Qing;Huang, Chuan-Man;Zhu, Li-Ping;Ye, De-Yong. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2005.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:

According to the principle of bioisosterism and the Evans’ pharmacophore model of 5-HT₃ receptor antagonists, twelve tetramethylpyrazine derivatives were synthesized. The structures of the compounds were confirmed by MS, ¹H NMR and HRMS. All the target compounds are unreported. The preliminary activity test showed that most of the compounds had fairly potent 5-HT₃ receptor antagonistic activities, especially compound I. The conformational anal. showed that the active conformation of the compounds was quite fitted to the Evans model. This indicates that besides the three pharmacophoric elements, the aromatic ring and the substituents attached may affect the bioactivities of the compounds In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

A unique, rigid porous coordination polymer with 1,4,5-triazanaphthalene and mixed-valence Cu as the bridging metal was written by van Albada, Gerard A.;Ghazzali, Mohamed;Al-Farhan, Khalid;Mutikainen, Ilpo;Reedijk, Jan. And the article was included in Inorganic Chemistry Communications in 2011.Product Details of 322-46-3 This article mentions the following:

A novel mixed-valence Cu(I)/Cu(II) compound with the bridging ligand 1,4,5-triazanaphthalene (tan) is reported, having the overall formula [Cu₂(tan)₄](ClO₄)₃. The synthesis, x-ray crystal structure and preliminary spectroscopic properties are presented. The coordination of Cu(I) is tetrahedral, and that of Cu(II) is square planar. The packing of the units generates a 3D network with spaces in the cavities, available for the counteranions and accessible for small solvent mols. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Copper perchlorate and tetrafluoridoborate compounds with the ligand 1,4,5-triazanaphthalene. Gradual transformation of mononuclear Cu(II) compounds via polynuclear mixed-valence Cu(ii)/Cu(i) species to dinuclear Cu(i); syntheses, characterizations and X-ray structures was written by van Albada, Gerard A.;Mutikainen, Ilpo;Ghazzali, Mohamed;Al-Farhan, Khalid;Reedijk, Jan. And the article was included in Dalton Transactions in 2012.Related Products of 322-46-3 This article mentions the following:

When the ligand 1,4,5-triazanaphthalene (abbreviated as tan) is reacted with Cu(II) BF₄^– and ClO₄^– salts, a variety of mononuclear compounds has been found, all with the [Cu(tan)₄] unit and varying amounts of weakly coordinating axial ligands and lattice solvents. Reproducible compounds formed include two purple compounds, analyzing as [Cu(tan)₄](ClO₄)₂(CH₃OH)₂(H₂O) (1) and [Cu(tan)₄](BF₄)₂(CH₃OH)_1.5(H₂O) (3), and two blue compounds, analyzing as [Cu(tan)₄](ClO₄)₂(H₂O)₂ (2) and [Cu(tan)₄]₂(BF₄)₂(H₂O)₂ (4). Upon standing at room temperature, red-colored, mixed-valence dinuclear-based 3D coordination polymers are formed by conversion of the purple/blue products, of which [Cu₂(tan)₄]_n(BF₄)_3n (5) and the isomorphic methanol-water adduct [Cu(tan)₄]_n(BF₄)_3n(CH₃OH)_n(H₂O)_5n (5A) are presented in this paper. In addition a fully reduced dinuclear Cu(I) compound of formula [Cu₂(tan)₃(ClO₄)₂] (7) has been observed, and structurally characterized, as a rare three-blade propeller structure, with a Cu-Cu distance of 2.504 Å. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Related Products of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Discovery of a new tetramethylpyrazine based chalcone with α, β-Unsaturated ketone moiety as a potential anticancer agent was written by Bukhari, Syed Nasir Abbas. And the article was included in International Journal of Research in Pharmaceutical Sciences (Madurai, India) in 2020.Related Products of 75907-74-3 This article mentions the following:

In this study, a new ligustrazine-based chalcone mol. has been synthesized that contains an extra alpha, beta-Unsaturated ketone moiety along with alpha, the beta-Unsaturated carbonyl group of chalone. A new tetramethylpyrazine (TMP) based aldehyde was synthesized to make the TMP (ligustrazine) as part of chalcone and then it was reacted with newly synthesized ketone containing addnl. alpha, beta-Unsaturated ketone moiety. After characterization, this new compound was evaluated for its effect on different types of cancer cell lines and very promising results were obtained. The growth of these cancer cells was inhibited by newly designed and synthesized compounds, especially for colon and pancreatic cancer cells with IC50 0.04 – 0.05 μM. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Related Products of 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Related Products of 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Determination of tetramethylpyrazine and its active metabolite in rat plasma by HPLC was written by Yuan, Fang;Chen, Zhuojia;Chen, Jie. And the article was included in Zhongguo Xiandai Yingyong Yaoxue in 2012.Application of 75907-74-3 This article mentions the following:

An HPLC method for the determination of concentration of tetramethylpyrazine (TMP) and its active metabolite, 2-hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) in rat plasma was established, and applied this method to the pharmacokinetic study of TMP. 2-Methylpyrazine was used as internal standard The alkalified serum samples were extracted with a chloroform-1-chloro-butane (3:1) induced liquid-liquid extraction The target analytes were quant. determined by HPLC. Hypersil BDS C₁₈ column (4.6 mm×250 mm, 5 μm) was used. The mobile phase consisted of 20 mmol · L^-1 potassium dihydrogen phosphate buffer (pH 5.6)-methanol (72:28). The flow rate was 1.0 mL · min^-1, 15 μL sample was injected and detected by the ultra-violet detector at 285 nm. The linearity was obtained over the concentration ranges of 0.03125-50 μg · mL^-1 for TMP (γ=0.9995) and 0.03125-5 μg · mL^-1 for HTMP (γ=0.9998). The lower limit of quantitation (LLOQ) was 0.03125 μg · mL^-1 for TMP and HTMP. The inter- and intra-batch precisions (RSD%) were less than 9% for both analyses. The accuracies and extracted recoveries were 86.2%-93.0% for TMP and 73.8%-95.1% for HTMP. The relative recoveries were 96.9%-117.7% for TMP and 97.5%-104.9% for HTMP. The method has good selectivity, acceptable accuracy, precision and sensitivity. It can be applied to pharmacokinetic study of TMP in rats. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application of 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Application of 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem