Tag: 100-200

Synthesis, characterization and molecular structures of some tetraosmium carbonyl clusters containing pyridine or phenanthroline type ligands was written by Choi, Ya-Yin;Wong, Wing-Tak. And the article was included in Journal of Organometallic Chemistry in 1999.COA of Formula: C7H5N3 This article mentions the following:

The reactions of activated tetraosmium carbonyl cluster [Os₄(μ-H)₄(CO)₁₁(NCMe)] (1) with monopyridyl ligands give new clusters [Os₄(μ-H)₄(CO)₁₁,(pyp)] (3) and [Os₄(μ-H)₄ (CO)₁₁(pya)] (4) (pyp = pyrido[2,3-b]pyrazine, pya = 4-pyridinecarboxaldehyde). Similarly, the reactions of [Os₄(μ-H)₄(CO)₁₀(NCMe)₂] (2) with bipyridyl or phenanthroline type ligands afford [Os₄(μ-H)₄(CO)₁₀(bpy)] (5), [Os₄(μ-H)₄ (CO)₁₀(4,4′-diphenyl-2,3-bipyridine)] (6), [Os₄(μ-H)₄(CO)₁₀(phen)] (7), [Os₄(μ-H)₄(CO)₁₀(2,9-dimethyl-4,4′-diphenyl-1,10-phenanthroline)] (8), and [Os₄(μ-H)₄(CO)₁₀(dipyrido[3,2-a:2′,3′-c]phenazine)] (9), which exhibit interesting ring conformations. Treatment of 2 with the N-P mixed donor ligand diphenyl-2-pyridylphosphine (dppy) gives a novel bridging cluster [Os₄(μ-H)₄(CO)₁₀(dppy)] (10). In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3COA of Formula: C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.COA of Formula: C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Time-resolved electron paramagnetic resonance investigation of photochemical reactions. Hydrogen abstraction in azaaromatics and carbonyls was written by Yamauchi, Seigo;Hirota, Noboru. And the article was included in Journal of Physical Chemistry in 1984.Related Products of 322-46-3 This article mentions the following:

Transient ESR spectra were observed for the intermediate radicals in the photoinduced H abstractions of azaarom. mols. and carbonyls in Me₂CHOH. Temperature dependence was examined at -10 to -90°. The intermediate radicals are assigned from the spectra with partially resolved hyperfine structures. The precursory excited states for the reactions are determined from the signal polarities, and their properties are discussed in terms of the possible CIDEP mechanisms. The reactions occur from the T₁(nπ^*) states with neg. D values or the T₁(ππ^*) states with pos. D in the cases of azaaroms. In aromatic carbonyls the reactions occur from the T₁(nπ^*) or T₂(nπ^*) states with neg. D values, while in aliphatic carbonyls, from the T₁(nπ^*) states with pos. D values. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Related Products of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of tetramethylpyrazine metabolites was written by Liu, Xinyong;Ge, Weiying;Xu, Lijun;Zhang, Junren;Wang, Haiyan;Pan, Shuju. And the article was included in Shandong Yike Daxue Xuebao in 1997.COA of Formula: C8H12N2O This article mentions the following:

2-Acetoxylmethyl-3,5,6-trimethylpyrazine, 3,5,6-trimethylpyrazine methanol and 3,5,6-trimethylpyrazine formic acid were prepared from tetramethylpyrazine oxidation The alc. and the acid were tested active in lowering both cholesterol and LDL level in rabbit. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3COA of Formula: C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.COA of Formula: C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Intramolecular Diels-Alder reaction of pyrazines with an alkenyl side chain was written by Chen, Bin;Yang, Chu-Yao;Ye, De-Yong. And the article was included in Tetrahedron Letters in 1996.Electric Literature of C8H12N2O This article mentions the following:

Intramol. Diels-Alder reaction of a series of pyrazines bearing a 5-membered-ω-alkene side chain, I (X = O, SO, SO₂, S), in refluxing trifluoroacetic acid led to the formation of bridged tricyclic compounds II. These cycloadducts underwent retro Diels-Alder reaction in refluxing nitrobenzene to give the original pyrazines. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Electric Literature of C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Electric Literature of C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Design, synthesis, and biological activities of novel Ligustrazine derivatives was written by Cheng, Xian-Chao;Liu, Xin-Yong;Xu, Wen-Fang;Guo, Xiu-Li;Ou, Yang. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Computed Properties of C8H12N2O This article mentions the following:

A series of novel Ligustrazine derivatives was designed, synthesized, and assayed for their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities. The results showed that most Ligustrazine derivatives exhibited lower EC₅₀ values for protective effects on the ECV-304 cells damaged by hydrogen peroxide in comparison with Ligustrazine. And some Ligustrazine derivatives presented better antiplatelet aggregation activities than Ligustrazine. The derivatives containing the bisphenylmethyl pharmacophore (7a-c) exhibited highest potency. Compound 7a displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound 7c was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Computed Properties of C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides was written by Wu, Jiang;Liu, Yafei;Lu, Changhui;Shen, Qilong. And the article was included in Chemical Science in 2016.Computed Properties of C4H2BrClN2 This article mentions the following:

Palladium-catalyzed difluoromethylthiolation of heteroaryl halides and triflates under mild conditions was described. A vast range of heteroaryl halides such as pyridyl, quinolinyl, benzothiazolyl, thiophenyl, carbazolyl and pyrazolyl halides could be difluoromethylthiolated efficiently, thus providing medicinal chemists with new tools for their search of new led compounds for drug discovery. Likewise, aryl iodides were difluoromethylthiolated in high yields under a modified reaction condition. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-chloropyrazine (cas: 912773-21-8Computed Properties of C4H2BrClN2).

2-Bromo-5-chloropyrazine (cas: 912773-21-8) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Computed Properties of C4H2BrClN2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Decisive increase of regioselectivity in radical substitutions: Minisci reaction in the two-phase system was written by Heinisch, Gottfried;Loetsch, Gerhard;Vieboeck, Franz. And the article was included in Angewandte Chemie in 1985.Safety of Ethyl pyrazine-2-carboxylate This article mentions the following:

The ethoxycarbonylation of isonicotinonitrile by EtO₂C• (formed from Et pyruvate, H₂O₂, FeSO₄, and H₂SO₄ in H₂O) gave I along with other mono- and disubstitution products. Addition of CH₂Cl₂ increased the yield of I appreciably. Similar results were obtained with nicotinonitrile and pyrazine. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Safety of Ethyl pyrazine-2-carboxylate).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Safety of Ethyl pyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The electronic spectra of N-heteroaromatic systems. IX. n → π transitions of polycyclic azines was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1962.Reference of 322-46-3 This article mentions the following:

The visible and ultraviolet spectra of some polycyclic azines were measured in hydrocarbon and hydroxylic solvents. The frequencies of the n → π bands are determined primarily by the energy of the lowest unoccupied orbital in the corresponding aromatic hydrocarbon and the 1-electron charge ds. in that orbital at the positions occupied by N atoms, together with ground-state interaction between the lone pair orbitals in the ortho diazines. The intensities of the diazine n → π bands increase with the sum of the 1-electron charge ds. at the N positions of the lowest unoccupied π orbital. Compounds investigated are quinoline, quinoxaline, 1,5- and 1,8-naphthyridine, cinnoline, quinazoline, phthalazine, 1,2,4-, 1,4,5-, and 1,4,6-triazanaphthalene, 1,3,5,8-and 1,4,5,8-tetraazanaphthalene, and phenazine. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Design and synthesis of indobufen esters was written by Li, Feng;Wang, Jie;Li, Jia-ming;Zuo, Jian. And the article was included in Anhui Yiyao in 2015.Computed Properties of C8H12N2O This article mentions the following:

Indobufen was used as starting material, and three Indobufen esters were designed and synthesized based on association principle and prodrug principle of medicinal chem. The structures of the target compounds were characterized by IR, MS, ¹H NMR and ¹³C NMR. The anti-platelet aggregation activity of the target compounds is being tested in vitro. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Computed Properties of C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis, Configurational Assignment and Conformational Analysis of β-Hydroxy Sulfoxides, Bioisosteres of Oxisuran Metabolites, and their O-Methyl Derivatives was written by Alvarez-Ibarra, C.;Cuervo-Rodriguez, R.;Fernandez-Monreal, M. C.;Ruiz, M. P.. And the article was included in Journal of Organic Chemistry in 1994.Synthetic Route of C7H8N2O2 This article mentions the following:

Synthesis, configurational assignment, and conformational anal. of diastereoisomers of 2-(methylsulfinyl)-1-(2-quinolyl)ethanol, 2-(methylsulfinyl)-1-(1-isoquinolyl)ethanol, 2-(methylsulfinyl)-1-(2-pyrazinyl)ethanol, and their O-Me derivatives are reported. The configurational assignment and conformational anal. of the two diastereoisomers of β-hydroxy sulfoxides and β-methoxy sulfoxides have been carried out from the observed vicinal coupling constants using the mol. mechanics force field (MMX) and the Altona relationship as fundamental tools. The conformational equilibrium is explained in terms of polar and steric factors. Of significant importance was the role of intramol. hydrogen bonding in the RS/SR isomers of β-hydroxy sulfoxides. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Synthetic Route of C7H8N2O2).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Synthetic Route of C7H8N2O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem