Tag: 100-200

Synthesis of 8H-pyrazolo[5′,1′:3,4]pyrazino[2,1-b]quinazolin-8-ones was written by Hrynyshyn, Yevhenii V.;Tsizorik, Nazar M.;Musiychuk, Anna R.;Bol’but, Andriy V.;Vovk, Mykhailo V.. And the article was included in Chemistry of Heterocyclic Compounds in 2017.COA of Formula: C7H7N3O The following contents are mentioned in the article:

4-Chloropyrazolo[1,5-a]pyrazines reacted with anthranilic acids forming 8H-pyrazolo[5′,1′:3,4]pyrazino[2,1-b]quinazolin-8-ones I (R¹ = H, CF₃, Me, NO₂; R² = H, OMe; R³ = H, Me, OMe) representing a new heterocyclic system. This study involved multiple reactions and reactants, such as 2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3COA of Formula: C7H7N3O).

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one (cas: 1314920-48-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.COA of Formula: C7H7N3O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Li, Yanyang; Zhou, Yan; Qian, Pengyu; Wang, Yongzhen; Jiang, Falong; Yao, Zhenglin; Hu, Wenxiang; Zhao, Yanjin; Li, Shuxin published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis and bioevaluation of novel benzamide derivatives as HDAC inhibitors》.Recommanded Product: 78109-26-9 The author mentioned the following in the article:

A series of novel benzamide derivatives was designed and synthesized as HDAC inhibitors. Exploration of the structure-activity relationships resulted in compounds that are potent in vitro. In addition, the best compound exhibited an acceptable pharmacokinetic profile with bioavailability in rat of 81% and could be considered as a candidate compound for further development. The results came from multiple reactions, including the reaction of 1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9Recommanded Product: 78109-26-9)

1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Recommanded Product: 78109-26-9

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

《Novel condensation of 2,3-epoxybutanal with 2-aminopyridine and 2-aminopyrazine. Synthesis and stability of 3-(1-hydroxyethyl)imidazo[1,2-a]azines》 was written by Lumma, William C. Jr.; Springer, James P.. Formula: C8H7N3O And the article was included in Journal of Organic Chemistry on August 28 ,1981. The article conveys some information:

The title condensations gave azines I (X = CH, N) in 53 and 26% yield, resp. I (X = N) was oxidized to give 81% ketone II. I were not easily accessible by functionalization of the parent heterocycles due to facile decomposition of the latter. The crystal structure of II was determined After reading the article, we found that the author used 1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9Formula: C8H7N3O)

1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Formula: C8H7N3O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Schiesser, Stefan; Hajek, Peter; Pople, Huw E.; Kaeck, Helena; Oester, Linda; Cox, Rhona J. published an article on January 5 ,2022. The article was titled 《Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 40972-42-7 The information in the text is summarized as follows:

Inhibition of mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) is a promising strategy to modulate NF-κB signaling, with the potential to treat B-cell lymphoma and autoimmune diseases. The discovery and optimization of (1s,4s)-N,N′-diaryl cyclohexane-1,4-diamines, I [R1 = pyrimidin-4-yl, [2-(trifluoromethyl)pyrimidin-4-yl], (3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl), etc.], II [R2 = [[4-(methylamino)cyclohexyl]amino], (4-aminocyclohexoxy), piperazin-1-yl, etc] and III [R3 = pyrimidin-4-yl, [2-(trifluoromethyl)pyrimidin-4-yl], [3-(trifluoromethyl)phenyl], etc] a novel series of allosteric MALT1 inhibitors, resulting in compound I [R1 = (3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)] with single digit micromolar cell potency was described. X-ray anal. confirms that this compound binds to an induced allosteric site in MALT1. Compound I [R1 = (3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)] was highly selective and has an excellent in vivo rat PK profile with low clearance and high oral bioavailability, making it a promising lead for further optimization. In the experiment, the researchers used 3,6-Dichloroimidazo[1,2-b]pyridazine(cas: 40972-42-7SDS of cas: 40972-42-7)

3,6-Dichloroimidazo[1,2-b]pyridazine(cas: 40972-42-7) belongs to pyrazines. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. SDS of cas: 40972-42-7

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem