Tag: 100-200

Ruthenium(II) and osmium(II) polypyridyl complexes of an asymmetric pyrazinyl- and pyridinyl-containing 1,2,4-triazole based ligand. Connectivity and physical properties of mononuclear complexes was written by Browne, Wesley R.;O’Connor, Christine M.;Hughes, Helen P.;Hage, Ronald;Walter, Olaf;Doering, Manfred;Gallagher, John F.;Vos, Johannes G.. And the article was included in Journal of the Chemical Society, Dalton Transactions in 2002.Recommanded Product: Ethyl pyrazine-2-carboxylate This article mentions the following:

The synthesis, purification and characterization of two coordination isomers of Ru(II) and Os(II) complexes containing the ligand 3-(pyrazin-2′-yl)-5-(pyridin-2”-yl)-1,2,4-triazole (Hppt) are described. The x-ray and mol. structure of [Ru(bipy)₂(ppt)]PF₆·MeOH (1a) is reported, where the Ru(bipy)₂-center is bound to the ppt^– ligand via the pyridine N and the N1 atom of the triazole ring. ¹H NMR spectroscopic measurements confirm that in the second isomer (1b) the Ru(bipy)₂-moiety is bound via the N2 atom of the triazole ring and the pyrazine ring. Partially deuterated metal complexes (d₈-bipy derivatives) were used to facilitate interpretation of ¹H NMR spectra. The redox and electronic properties indicate that there are significant differences in the electronic properties of the two coordination isomers obtained. The acid-base properties of the compounds are also reported and show that the pK_a of the 1,2,4-triazole ring varies systematically depending on the nature of the noncoordinating substituent. Anal. of these data indicates a significant electronic interaction between the pyridyl/pyrazyl rings and the 1,2,4-triazole ring in the coordinated ppt^– ligand. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Recommanded Product: Ethyl pyrazine-2-carboxylate).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Recommanded Product: Ethyl pyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis, spectroscopic analyses (FT-IR and NMR), vibrational study, chemical reactivity and molecular docking study and anti-tubercular activity of condensed oxadiazole and pyrazine derivatives was written by El-Azab, Adel S.;Mary, Y. Sheena;Abdel-Aziz, Alaa A. M.;Miniyar, Pankaj B.;Armakovic, Stevan;Armakovic, Sanja J.. And the article was included in Journal of Molecular Structure in 2018.Application In Synthesis of Ethyl pyrazine-2-carboxylate This article mentions the following:

The Fourier transform IR spectra of the compounds 2-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrazine (PHOXPY), 2-(5-styryl-1,3,4-oxadiazol-2-yl)pyrazine (STOXPY) and 2-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)pyrazine (FUOXPY) have been recorded and the wavenumbers are computed at the d. functional theory level. The assignments of all the fundamental bands of each mol. are made using potential energy distribution. The computed values of dipole moment, polarizability and hyperpolarizability values indicate that the title mols. exhibit NLO properties. The HOMO and LUMO energies demonstrate the chem. stability of the mols. and NBO anal. is made to study the stability of mols. arising from hyper conjugative interactions and charge delocalization. Detailed computational anal. and spectroscopic characterization has been performed for three newly synthesized oxadiazole derivatives Obtained computational and exptl. results have been mutually compared in order to understand the influence of structural parts specific for each derivative From the MIC determination, MTb H37Rv was found to be sensitive to compounds, PHOXPY, STOXPY and FUOXPY. The results obtained from anti-TB activity are more promising as the compounds were found to be more potent than reference standards, streptomycin and pyrazinamide. Efforts were made in order to predict both global and local reactive properties of the title oxadiazole derivatives, including their sensitivity towards autoxidation mechanism and influence of water. The results obtained from anti-TB activity are more promising for the title compounds Interaction with representative protein Pterindeaminase inhibitor asricin A was also investigated using the mol. docking procedure. The docked ligands form stable complexes with the receptor ricin A and the docking results suggest that these compounds can be developed as new anti-cancer drugs. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Application In Synthesis of Ethyl pyrazine-2-carboxylate).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Application In Synthesis of Ethyl pyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

2,3-Dihydroxy-1,4-dioxane: a stable synthetic equivalent of anhydrous glyoxal was written by Venuti, Michael C.. And the article was included in Synthesis in 1982.Reference of 322-46-3 This article mentions the following:

1,4-Dioxane-2,3-diol (I) was obtained in 45% yield by treating aqueous glyoxal with ethylene glycol. I reacts as glyoxal with diamines, aldehydes, alcs., and thio ethers to give, e.g., quinoxaline, isonaphthazarin, and 2,5-bis(4-bromobenzoyl)thiophene. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Optical and magnetic properties of the lowest triplet state of pyrido(2,3-b)pyrazine. An example of ³nπ* azanaphthalene was written by Yamauchi, Seigo;Hirota, Noboru. And the article was included in Journal of Physical Chemistry in 1987.Name: Pyrido[2,3-b]pyrazine This article mentions the following:

The lowest excited triplet (T₁) states of pyrido(2,3-b)pyrazine (PP; 1,4,5-triazanaphthalene) in 3 kinds of environments were studied by using various spectroscopic and magnetic resonance techniques. Phosphorescence emission and excitation spectra, triplet lifetimes, zero field splittings (zfs), and triplet sublevel properties were obtained. From the anal. of the results T₁ is ³nπ^* in character in a single crystal of durene and in EtOH, but it is ³ππ^* in trifluoroethanol. Observation of the ³nπ^* phosphorescence was made for the 1st time in azanaphthalenes, which provides direct information about ³nπ^* azanaphthalene. The 0-0 band and vibronic bands involving a’ vibrations are dominant in the phosphorescence spectrum. Large zfs and neg. D (≡ -311₂x; -3.1 GHz) were obtained. As for the sublevel properties T_z is the most active and T_x is inactive in both radiative and nonradiative processes, whereas T_y is moderately active in the T₁ ∼→ S₀ nonradiative decay process. These ³nπ^* properties are discussed in comparison with those of ³ππ^* PP and azanaphthalenes and ³nπ^* azabenzenes. Possible mechanisms to explain the radiative and nonradiative properties are given. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Name: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Name: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine on cardiovascular system was written by Chen, Xue-Min;Cao, Yong-Xiao;Li, Guan-Wu;Lin, Zhang-Quan;Li, Xue-Fei;Liu, Jing. And the article was included in Zhongguo Yiyao Gongye Zazhi in 1998.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:

The cardiovascular effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine (I), one of the major metabolites of tetramethylpyrazine, were studied. I significantly prolonged cardiac potential lasting time and blood coagulating time in mice. It also significantly deduced the arterial blood pressure but had no effect on heart rates in rats. It was demonstrated that I improved the anoxemia-resistant ability and had the effects of antihypertension and anticoagulation. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Quality Control of (3,5,6-Trimethylpyrazin-2-yl)methanol

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The preparation of 2-amino-5-pyrazinecarboxylic acid and its derivatives was written by Felder, E.;Pitre, D.;Grabitz, E. B.. And the article was included in Helvetica Chimica Acta in 1964.Synthetic Route of C5H6N4O This article mentions the following:

2-Acetamidoquinoxazoline was treated with KMnO₄ in small portions over 1 hr. at 90-5° to give 60% mono-K salt (I) of 2-acetamidopyrazine-5,6-dicarboxylic acid, m. 293° (decomposition). I (1 g.) refluxed 0.5 hr. in 35 ml. H₂O with 5 ml. N HCl gave 0.7 g. 2-aminopyrazine-5,6-dicarboxylic acid, m. 262° (decomposition), which, heated in H₂O 12 min. at 170-5°, gave 77% 2-aminopyrazine-5-carboxylic acid (II), m. 282-3° (decomposition); 70% Me ester (MeOH-HCl) m. 230-1°; Et ester m. 172-3°; amide m. 266-7°. II was treated in H₂SO₄ with NaNO₂ at 5° and the mixture heated 5 min. at 80° to give 2-hydroxypyrazine-5-carboxylic acid, m. 300°. In the experiment, the researchers used many compounds, for example, 5-Aminopyrazine-2-carboxamide (cas: 89323-09-1Synthetic Route of C5H6N4O).

5-Aminopyrazine-2-carboxamide (cas: 89323-09-1) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Synthetic Route of C5H6N4O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Selective reductive cross-coupling of N-heteroarenes by an unsymmetrical PNP-ligated manganese catalyst was written by Tan, Zhenda;Xiong, Biao;Yang, Jian;Ci, Chenggang;Jiang, Huanfeng;Zhang, Min. And the article was included in Journal of Catalysis in 2020.Electric Literature of C7H5N3 This article mentions the following:

Herein, by developing an unprecedented manganese catalyst ligating with an unsym. 2-aminotetrahydronaphthyridyl PNP-ligands e.g., I, a new reductive cross-coupling of indoles II (R = H, 5-MeO, 7-Me, 2,5-di-Me, etc.)/1H-pyrrole, 2,5-dimethyl-1H-pyrrole and N-heteroarenes III (R¹ = H, 2,3-di-Me, 4-chlorophenyl, thiophen-2-yl, etc.; X = CH, N) was achieved. Mechanistic investigations show that the catalyst-enabled in situ capture of the partially reduced intermediates by interruption of the second transfer hydrogenation of N-heteroarenes constitutes the key to success for the present reaction. The developed chem. proceeds with good substrate and functional group compatibility, high step and atom efficiency, and excellent chemo and regioselectivity, and is applicable for late-stage modification of pyridine-containing biomedical mols., which has established a new platform allowing the linkage of aromatic systems into functional frameworks, and further development of unsym. PNP organometallic complexes and related catalytic transformations. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Electric Literature of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Fluorescent properties of aromatic complexes with rare earths and other Group IIIB elements was written by Kallistratos, George;Kallistratos, U.;Muendner, H.. And the article was included in Chimika Chronika in 1982.Synthetic Route of C7H5N3 This article mentions the following:

A number of aromatic complexes with rare earths and other elements of Group IIIa of the periodical system were synthesized. Many of these complexes exhibit a strong monochromatic fluorescence when excited with UV light. The formation of complexes is indicated through their physicochem. properties. Three mechanisms which could be responsible for the enhancement of the fluorescence were investigated. The complexes reported possess very important phys., chem. and biol. properties which could be applied in several fields of science. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Synthetic Route of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Synthetic Route of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of compounds of pyridopyrazinedione/imidazole was written by Xia, Yong-gen;Lu, Ming. And the article was included in Jingxi Huagong Zhongjianti in 2014.Electric Literature of C7H5N3 This article mentions the following:

Several pyridopyrazinedione, pyridinoimidazole and pyridodiimidazole compounds were synthesized from 2,3-diaminopyridine and 2,3,5,6-tetraaminopyridine hydrochloride, and the reaction conditions were investigated. NH₄Cl-CH₃OH system has significant catalytic effects on synthesis of 2,3-dimethypyrido[2,3-b]pyrazine and 2,3-diethypyrido[2,3-b]pyrazine. Replacement of glyoxal with 4,5-dihydroxy-imidazolidin-2-one increased the product yield by its reaction with 2,3-diaminopyridine. Phosphomolybdic acid was a preferred catalyst for the preparation of pyridinoimidazole and 2-Me pyridinoimidazole. Likewise, 2,3,5,6-tetraaminopyridine hydrochloride was reacted with tri-Et orthoformate and tri-Me orthoacetate under catalysis of phosphomolybdic acid gave 2,6-dihydro-pyrido[2,3-b:5,6-b’]diimidazole and 2,6-dimethy-pyrido [2,3-b:5,6-b’]diimidazole in yield of 68.7% and 66.5%, resp. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Electric Literature of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Electric Literature of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Homolytic alkoxycarbonylation reactions in two-phase systems. Part II. Studies on the ethoxycarbonylation of some selected π-deficient N-heteroaromatic systems was written by Heinisch, Gottfried;Loetsch, Gerhard. And the article was included in Tetrahedron in 1986.Related Products of 6924-68-1 This article mentions the following:

Qadical substitution of pyridine, 4-methylpyridine (I; R = H) and pyrazine (II; R = H) with EtO₂C• generated from AcCO₂Et and H₂O₂ in an aqueous system gave less than 30% conversion, little selectivity, and significant quantities of disubstitution products. However, in a two-phase system prepared by adding CH₂Cl₂, I and II (R = H) gave single monosubstitution products, I and II (R = CO₂Et) in 53 and 89% yields, resp. With pyridine and quinoline, the two phase system increases conversion to over 90% but disubstitution products continued to dominate. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Related Products of 6924-68-1).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Related Products of 6924-68-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem