Tag: 100-200

Pyrido[2,3-b]- and -[3,4-b]pyrazines was written by Boutte, Daniel;Queguiner, Guy;Pastour, Paul. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1971.Name: Pyrido[2,3-b]pyrazine This article mentions the following:

Reduction, oxidation, and treatment by organometallic reagents and alkyl iodides of pyrido[2,3-b]- (I) and pyrido[3,4-b]pyrazine (II) are reported. Reduction of I and II with LiAlH4 gives the resp. 1,2,3,4-tetrahydro derivatives (III and IV). Reaction of III with 1 and 2 moles BzCl gives the 1-benzoyl and 1,4-dibenzoyl derivatives, resp. IV gives only a 1,4-dibenzoyl derivative Oxidn of II by KMnO4 at 100° gives, after esterification with EtOH, di-Et 2,3-pyrazine-dicarboxylate. Under similar conditions, the 2,3-di-Me derivative (V) of II gives di-Et 5,6-dimethyl-2,3-pyrazinedicarboxylate. Reaction of I with MeMgI in Et2O at 25° gives only the 2,3-di-Me2 derivative (IV) of III. II similarly gives the 2,3-di-Me derivative (VII) of IV. EtMgI with I in THF gives 20% 6-ethyl-5,6-dihydropyrido[2,3-b]pyrazine. With KMnO4 in Me2CO, VI gives the 2,3-di-Me derivative of I, but VII in air spontaneously gives V. Reaction of II with 4-O2NC6H4CO2O in Et2O gives the 6-oxide. No N-oxide from I was isolable. Oxidation of I with the 3 peracids gives only IX-X, (IX predominating). In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Name: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Name: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Infrared study of hydrogen bonds involving N-heterocyclic bases and phenols was written by Goethals, Muriel;Czarnik-Matusewicz, Boguslawa;Zeegers-Huyskens, Therese. And the article was included in Journal of Heterocyclic Chemistry in 1999.Formula: C7H5N3 This article mentions the following:

The hydrogen bond complexes between phenols and N-heteroaromatic bases 2,4,6-tri(2-pyridyl)-1,3,5-triazine, 2,2′,2″-terpyridine, quinoxaline, pyrido[2,3-b]pyrazine, pyzazino[2,3-f]quinoxaline and 5-nitrophenanthroline are investigated by IR spectroscopy in 1,2-dichloroethane. The stability constants of the complexes involving N-heteroaromatic bases characterized by two vicinal nitrogen atoms having lone pairs pointing to each other are higher than predicted from their basicity. Possible differences between protonation and hydrogen bond formation are discussed. N-heteroaromatic bases such as tri(2-pyridyl)-1,3,5-triazine or phenanthrolines cannot be considered as proton sponges but their behavior is intermediate between that of the classical heteroaromatic bases and the proton sponges. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Formula: C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Formula: C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Discovery of tetrasubstituted pyrazines as semiochemicals in a sexually deceptive orchid was written by Bohman, Bjorn;Jeffares, Lynne;Flematti, Gavin;Byrne, Lindsay T.;Skelton, Brian W.;Phillips, Ryan D.;Dixon, Kingsley W.;Peakall, Rod;Barrow, Russell A.. And the article was included in Journal of Natural Products in 2012.HPLC of Formula: 75907-74-3 This article mentions the following:

Sexually deceptive orchids employ mimicry of insect sex pheromones to exploit a diverse group of pollinators. The chem. structures of five semiochems. (1-3, 7, 8) produced by populations of the warty hammer orchid, Drakaea livida, pollinated by a thynnine wasp in the genus Catocheilus were elucidated. With the exception of (2,5-dimethylpyrazin-3-yl)methyl 3-methylbutanoate (7), all active compounds were tetrasubstituted pyrazines, including hydroxymethyl (1) and ester (2 and 3) trimethylpyrazine derivatives Male Catocheilus wasps were responsive to all of these compounds in GC-EAD experiments In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3HPLC of Formula: 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.HPLC of Formula: 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Study of the reaction of organomagnesium compounds with pyrido[2,3-b]pyrazines was written by Vinot, Nicole;Maitte, Pierre. And the article was included in Bulletin de la Societe Chimique de France in 1976.Computed Properties of C7H5N3 This article mentions the following:

Pyridopyrazines I (R = H, Br, R1 = R2 = H) reacted with organomagnesium halides to give tetrahydropyridopyrazines II (R = H, Br, R3 = Me, Et, vinyl, Ph). I (R = H, Br, R1 = R2 = Ph) similarly gave III (R3 = Me, Et), I (R = R2 = H, R1 = Ph) gave IV (R3 = Me, Ph), and I (R = Br, R1 = Ph, R2 = H) gave V. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazinesare six-membered aromatic heterocyclic organic compounds with two nitrogen atoms at 1,4-positions. Pyrazine is a weaker base (pKb = 13.4) than pyridine (pKb = 8.8), pyrimidine (pKb = 12.7). Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Computed Properties of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

π-Electron structure of some nitrogen heterocycles: azanaphthalenes, azaanthracenes and azaphenanthrenes was written by Birss, F. W.;Das Gupta, N. K.. And the article was included in Indian Journal of Chemistry in 1979.Computed Properties of C7H5N3 This article mentions the following:

The resonance energies of azanaphthalenes, azaanthracenes and azaphenanthrenes are predicted by means of empirical relation. The results are in good agreement with the Dewar resonance energy for the mols. studied. The effect of the N at different centers on the ground state properties was also discussed. Ionization potential, electron affinity and π-dipole moment were predicted and compared with exptl. ones where available. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Computed Properties of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Fourier-transform infrared and Raman spectra, vibrational assignment and density functional theory calculations of 1,4,5-triazanaphthalene was written by Krishnakumar, V.;Ramasamy, R.. And the article was included in Journal of Raman Spectroscopy in 2009.Computed Properties of C7H5N3 This article mentions the following:

The Fourier-transform IR (FT-IR) (4000-50 cm^-1) and Raman spectra (3500-100 cm^-1) of 1,4,5-triazanaphthalene in polycrystalline state were measured. Comparison between the spectra by 2 techniques, a series of d. functional theory (DFT) calculations and the spectral behavior upon deuteration were used for the assignment of the vibrational spectra of the title compound The calculated vibrational wavenumbers by the B3LYP d. functionals are generally consistent with the observed spectra. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Computed Properties of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Proton NMR spectra and structures of some bicyclic compounds oriented in nematic phases was written by Diehl, P.;Zimmermann, H.. And the article was included in Organic Magnetic Resonance in 1976.Product Details of 322-46-3 This article mentions the following:

The PMR spectra of 1,4,5-triazanaphthalene, benzothiazole, and quinoline, oriented in nematic liquid crystalline phases, were analyzed and the parameters used to determine interproton distance ratios. The symmetry of the benzene ring was violated when compared to the nonhetero analogs. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines was written by Venkat Ragavan, R.;Vijayakumar, V.;Rajesh, K.;Palakshi Reddy, B.;Karthikeyan, S.;Suchetha Kumari, N.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: pyrazines This article mentions the following:

A series of β-keto esters were synthesized from heteroaryl esters and Et acetate using LiHMDS as base at -50 to -30 °C. Increases in yields of cross-condensed products were observed and the percentage of self-condensed product was reduced drastically by applying the suitable base (LiHMDS), solvent, and a min. amount of Et acetate. All these β-keto esters were characterized using ¹H NMR, ¹³C NMR and mass spectral data. A plausible mechanism is also depicted to prove the formation of trans-esterified products. All the synthesized compounds were tested for their cytotoxicity towards various cancer cell lines and also tested for their antimicrobial activity towards various bacterial and fungal strains and some of them were found to have promising activity. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Category: pyrazines).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Category: pyrazines

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Protective effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine on vascular endothelial cells injured by hydrogen peroxide was written by Li, Chaowu;Liu, Xinyong;Zhang, Rui;Xu, Wenfang;Li, Zhong;Wang, Defeng. And the article was included in Shandong Daxue Xuebao, Yixueban in 2003.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:

The protective effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) on human umbilical vein endothelial cells (HUVECs) injured by H₂O₂ were studied. HUVECs viability was assessed by Me thiazolyl tetrazolium assay and tetramethylpyrazine (TMP) was used as a controlled drug. HTMP (0.1-1.5 mM) highly stimulated the proliferation of normal HUVECs, and protected the injured HUVECs against suppression induced by H₂O₂, which had more potency than the pos. drug TMP. The exptl. data suggested that HTMP exerted protective action on injured HUVECs and had a great significance for repairing the injured endothelium in treatment of cardiovascular diseases. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ligustrazine Derivatives. Part 8: Design, Synthesis, and Preliminary Biological Evaluation of Novel Ligustrazinyl Amides as Cardiovascular Agents was written by Li, Zhenyu;Yu, Fang;Cui, Lei;Chen, Wenmin;Wang, Shouxun;Zhan, Peng;Shen, Yuemao;Liu, Xinyong. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2014.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:

A series of novel Ligustrazinyl amides was designed, synthesized and evaluated for their protective effect on the injured vascular endothelial cells. The preliminary results demonstrated that some compounds possessed more potent activities than that of Ligustrazine in stimulating replication of the injured human umbilical vascular endothelial cells (HUVECs) that is damaged by hydrogen peroxide. Among the active compounds, compounds 8i, 8t and 8u exhibited the highest potency with low EC50 values of 0.037, 0.070 and 0.055 mM, resp. Structure-activity relationships were briefly discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem