Tag: 100-200

Continuous flow as an enabling technology: a fast and versatile entry to functionalized glyoxal derivatives was written by Lima, Fabio;Meisenbach, Mark;Schenkel, Berthold;Sedelmeier, Joerg. And the article was included in Organic & Biomolecular Chemistry in 2021.Application In Synthesis of Ethyl pyrazine-2-carboxylate This article mentions the following:

Two complementary strategies employing organolithium chem. for the synthesis of glyoxal derivatives RC(O)R¹R² (R = methoxymethyl, 3,5-difluorophenyl, pyridin-2-yl, quinolin-6-yl, etc.; R¹ = Cl, OEt, H; R² = Cl, OEt, 3-chlorophenyl) were reported. Micro-mixer technol. allows for the generation of unstable organometallic intermediates and their instantaneous in-line quenching with esters as electrophiles RC(O)OEt. Selective mono-addition was observed via putative stabilized tetrahedral intermediates. Advantages offered by flow chem. technologies facilitate direct and efficient access to masked 1,2-dicarbonyl compounds while mitigating undesired byproduct formation. These two approaches enable the production of advanced and valuable synthetic building blocks for heterocyclic chem. with throughputs of grams per min. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Application In Synthesis of Ethyl pyrazine-2-carboxylate).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Application In Synthesis of Ethyl pyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Mononuclear and polynuclear halide and nitrate Cu(II) compounds with 1,4,5-triazanaphthalene as a ligand: Characterization, magnetism and X-ray structures was written by van Albada, Gerard A.;van der Horst, Maarten G.;Fu, Wen Tian;Roubeau, Olivier;Mutikainen, Ilpo;Turpeinen, Urho;Reedijk, Jan. And the article was included in Inorganica Chimica Acta in 2009.Recommanded Product: Pyrido[2,3-b]pyrazine This article mentions the following:

Using the ligand 1,4,5-triazanaphthalene (abbreviated as tan) in reaction with Cu(II) salts, three mononuclear compounds, Cu(tan)₂Cl₂ (1), Cu(tan)₂Br₂ (3), Cu(tan)₂(NO₃)₂ (5) and three polynuclear compounds, [Cu(tan)Cl₂]_n (2), [Cu(tan)Br₂]_n (4), [Cu(tan)(NO₃)₂]_n (6) were prepared and characterized by UV-visible, EPR, FTIR and Far-FTIR spectroscopies. The crystal structures of compounds 1, 3, 5 and 6 are reported, as well as that of the dioxane adduct of compound 4, [Cu(tan)Br₂(C₄H₈O₂)](C₄H₈O₂) (4A). The structure of 2 was solved by x-ray powder diffraction. The coordination geometry around the Cu(II) atoms is tetrahedral for (1) and (3), square-pyramidal for (4A) and distorted octahedral for (5) and (6). Magnetic susceptibility measurements on the polynuclear compounds revealed weak antiferromagnetic interactions between the Cu(II) atoms with interaction constants (J) of J = -9.1 and -10.5 cm^-1, for 4 and 6, resp. For compound 2 two options for possible interactions were considered, with interaction constants which vary for J _rung -22.0 to -13.5 cm^-1 and J _rail -19.6 to -17.0 cm^-1. These figures are discussed in the light of relevant structural parameters and literature. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: Pyrido[2,3-b]pyrazine).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine derivatives have antitumor, antibiotic, anticonvulsant, antituberculous and diuretic effects as well as kinase, enzymatic and potent tubulin and FtsZ polymerization inhibitory activities. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Recommanded Product: Pyrido[2,3-b]pyrazine

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Novel transformation of 1,2,4-triazines into pyrazine derivatives was written by Alekseev, S. G.;Charushin, V. N.;Chupakhin, O. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1987.Reference of 322-46-3 This article mentions the following:

Pyrazines I (X = e.g. CH, N) were prepared by the reaction of aromatic o-diamines with triazinium salt II and subsequent elimination of morpholinoamidrazone from the intermediate III. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Reference of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Oxidation of hydroxymethylpyrazines and hydroxylated phenyl compounds in a gas chromatography inlet was written by Bohman, B.;Flematti, G. R.. And the article was included in Analytical Methods in 2015.Application of 75907-74-3 This article mentions the following:

Large proportions of aldehydes were formed when hydroxymethylpyrazines, and benzyl- and cinnamyl alcs. were analyzed by gas chromatog.-mass spectrometry using a heated inlet with a previously used glass inlet liner. To avoid false reporting of non-natural compounds, any identification of aldehydes potentially formed in a GC inlet requires verification. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application of 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Application of 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis of novel ligustrazine derivatives as potential platelet aggregation inhibitors was written by Cheng, Xian Chao;Liu, Xin Yong;Xu, Wen Fang. And the article was included in Chinese Chemical Letters in 2006.Related Products of 75907-74-3 This article mentions the following:

A series of novel ligustrazine derivatives were synthesized. These compounds have not been reported in literature, and their chem. structures were confirmed by IR, ¹H NMR and ESI-MS. The preliminary antiplatelet aggregation screening results demonstrated that the compounds 7a, 7b and 7c showed higher potency than ligustrazine. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Related Products of 75907-74-3).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.Related Products of 75907-74-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthesis and Biological Evaluation of Ligustrazine Derivatives was written by Zhang, Chao;Chen, Lang-di;Liang, Xin-tong;Liu, Wei-xiong;Wu, Wen-hao. And the article was included in Chemistry of Natural Compounds in 2017.Formula: C8H12N2O This article mentions the following:

Synthesized ligustrazine derivatives (1a, 1b, 1c (novel)) were structurally confirmed by mass spectrometry, ¹H NMR, and ¹³C NMR. The cytotoxic activities of all derivatives were evaluated by MTS assay in three human prostate cancer cell lines (PC-3, LNCaP, and DU145) and in the A549 human lung cancer cell line. Compound 1a exhibited strong cytotoxic activity against PC-3 cells (IC₅₀ 3.63 μM). In addition, compounds 1-1c showed moderate α₁-adrenergic receptor (AR) subselective antagonistic and β₂-AR agonistic effects, indicating potential use for the treatment of chronic obstructive pulmonary disease. Mol. docking results showed 1b bound to one region of the active site in β₂-AR, but 1, 1a, and 1c bound to a different region. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Formula: C8H12N2O).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Formula: C8H12N2O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Spin polarization conservation during triplet-triplet energy transfer in fluid solution as studied by time-resolved ESR spectroscopy was written by Akiyama, Kimio;Kaneko, Atsuko;Tero-Kubota, Shozo;Ikegami, Yusaku. And the article was included in Journal of the American Chemical Society in 1990.Related Products of 322-46-3 This article mentions the following:

Electron polarization of pyridinyl radicals generated from the photosensitized dissociation of the dimers was studied. Addition of triplet sensitizer to the dimer solution induced drastic change in the CIDEP spectrum. Examinations of the dependence of spectral change on the T₁ state energy level and the spin alignment in the T₁ sublevels of sensitizers lead to the conclusion that energy transfer between the pyridinyl dimer and the sensitizer occurred and that the spin polarization was conserved during the process. From a series of triplet donors, nonphosphorescent T₁ states of two types of pyridinyl dimers were estimated to be 2.43 eV for the 2,2′-dimer of 1-methyl-4-tert-butylpyridinyl and 2.65 eV for the 4,4′-dimer of 1-methylpyridinyl. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Related Products of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Related Products of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Quantum-chemical description of the basicity of azanaphthalenes was written by Zarqua, Tamar;Kereselidze, Jumber;Pachulia, Zurab. And the article was included in Sakartvelos Mecnierebata Akademiis Macne, Kimiis Seria in 2008.Recommanded Product: 322-46-3 This article mentions the following:

Energetic and electronic characteristics of azanaphalenes have been calculated by means of semiempirical quantum-chem. AM1 method. It is shown that basicity of azanaphalenes linearly depends on enthalpy and sum of charge of nitrogen atoms, and the dependence on ionization potential is second order. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Recommanded Product: 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Recommanded Product: 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pyridazine analogs of biologically active compounds. Part III. Synthetic investigations directed to azanicotines and congeners was written by Heinisch, Gottfried;Jentzsch, Alexander;Kirchner, Ingrid;Loetsch, Gerhard. And the article was included in Vestnik Slovenskega Kemijskega Drustva in 1986.Electric Literature of C7H8N2O2 This article mentions the following:

Synthetic approaches providing access to novel analogs of nicotine, e.g., I (R = Me) and nornicotine, e.g., I (R = H) are investigated. Homolytic α-N-amidoalkylation permits C-C bond formation between pyridazine (C-4), pyrimidine (C-4), pyrazine (C-2) or quinoline (C-4) and N-formyl- or N-acetyl-pyrrolidine. The N-formylnornicotinoids are converted into 1-methyl-2-heteroarylpyrrolidines by reduction Hydrolysis of the corresponding N-acetyl derivatives affords aza-nor-nicotines and related compounds In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Electric Literature of C7H8N2O2).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Electric Literature of C7H8N2O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pyrazine derivatives. VIII. Preparation of some amino pyrazines by the Curtius reaction was written by Schut, W. J.;Mager, H. I. X.;Barends, W.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1963.Related Products of 89323-09-1 This article mentions the following:

2 – (N – Benzyloxycarbonylamino) – 5 – ethoxycarbonylpyrazine (I) (6.025 g.) and 150 ml. 4N HCl refluxed 3 hrs., evaporated to dryness in vacuo, 10 ml. H₂O added, the pH adjusted to 3, and the precipitate filtered off gave 2.1 g. 2-aminopyrazine-5-carboxylic acid (II), m. 283° (decomposition) (evacuated tube in bath preheated to 260°) (H₂O). To a hydrogenated mixture of 95 mg.% Pd-C and 20 mg. 3% aqueous NaOH was added 0.9563 g. I and the whole hydrogenated at room temperature and atm. press., 90 ml. H₂O added, the mixture filtered, the filtrate concentrated in vacuo to 10 ml., the pH adjusted to 3, and the solid filtered off gave 0.445 g. II. Hydrogenation of 1.2052 g. I, 120 mg. 10% Pd-C, and 30 ml. 96% EtOH gave 0.656 g. 2-amino-5-ethoxycarbonylpyrazine, m. 174-5°. Similarly, 2-(N-benzyloxycarbonylamino)-5-carba-moylpyrazine (III) gave 87% 2-amino-5-carbamoylpyrazine, m. 274-6°. I (2g.) in 75 ml. EtOH saturated at 0° with NH₃ and the whole kept 4 days at -5° gave 1.57 g. III. In the experiment, the researchers used many compounds, for example, 5-Aminopyrazine-2-carboxamide (cas: 89323-09-1Related Products of 89323-09-1).

5-Aminopyrazine-2-carboxamide (cas: 89323-09-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Related Products of 89323-09-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem