Pyrazines

Related Products of 27825-21-4, The chemical industry reduces the impact on the environment during synthesis 27825-21-4, name is Methyl 3-chloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.

To asolution of the product from step 1 (100 mg, 0.58 mmol) in toluene (2 mL)was added Pd(PPh3)4 (134 mg, 0.12 mmol) and 2-(tributylstannyl)pyridine (213 mg, 0.58 mmol) at room temperature and the resulting mixture heated to 100C overnight. After cooling to RT, the mixture was filtered and 5mL of aq. KF solution was added to the filtrate. The resulting mixture was stirred for 30 mins and extracted with EtOAc (5 mL x 3). The combined organic layers were washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography (30% EtOAc in petroleum ether) to provide the title compound as an oil. LRMS m/z (M+H) 216.1 found, 216.1 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 6164-79-0,Some common heterocyclic compound, 6164-79-0, name is Methyl 2-pyrazinecarboxylate, molecular formula is C6H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of an appropriate methyl esters17(a-j) (1.0 mmol) in 50 mL of methanol was added 99 %hydrazine hydrate (4.0 mmol) and the mixture was refluxedfor 5 h up to reaction completed (TLC). After completionof reaction, it was allowed to cool and the obtained solidwas washed with methanol. The crude products wererecrystallized from ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-pyrazinecarboxylate, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33332-28-4 as follows. Computed Properties of C4H4ClN3

To a stirred solution of 6-chloropyrazin-2-amine (0.500 g, 3.85 mmol, 1.0 eq.) in xylene (20.0 mL) was added 2-(tributylstannyl)pyridine reagent (1.42 g, 3.85 mmol, 1.0 eq.). The reaction mixture was deoxygenated using N2 gas and Pd(PPh3)4 (0.223 g, 0.05 eq. 0.192 mmol) was added. The reaction mixture was again purged with N2 and allowed to heat at 150° C. for 16 h in seal tube. Progress of the reaction was monitored by TLC and LCMS Reaction mixture was allowed to cool to RT and quenched by adding aq. NaOH and extracted using ethyl acetate (3*100 mL). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum to get the solid which was purified by normal phase column chromatography to get the desired product (0.400 g, 60percent).

According to the analysis of related databases, 33332-28-4, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4774-14-5 as follows. name: 2,6-Dichloropyrazine

2,6-Dichloropyrazine (55 g, 0.37 mol) and formamide (300 mL) were combined and heated to 90 C. Sodium persulfate (86.7 g, 0.36 mol) was added to the mixture at 90 C. in Ig portions at 20-30 seconds intervals. An exotherm was observed and the color of the mixture turned from yellow to dark red/brown. The mixture was stirred at 90 C. for 2 h and then cooled to room temperature. The mixture was diluted with water (500 mL) and filtered. The filtrate layers were separated. The aqueous layer was extracted with IPA:chloroform (1:3, 3*750 mL). The combined organic layers were dried over sodium sulfate and concentrated under vacuum to afford a viscous oil. The oil was purified by silica gel chromatography (0 to 100% ethyl acetate in hexanes) to provide the title product as a colorless solid (25 g, 36% yield).

According to the analysis of related databases, 4774-14-5, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 51171-02-9

(B) Methyl 2-phenylamino-3-pyrazine carboxylate A mixture of 9.5 g. of methyl 2-bromo-3-pyrazine carboxylate, 8.2 g. of aniline, 0.5 g. of p-toluene sulfonic acid and 100 ml. of water is stirred and refluxed for two hours. The reaction mixture is poured on ice, extracted with ethyl acetate, the organic extracts are dried and concentrated to yield an oil. The crude residue is eluted on a silica gel column with ethylacetate-hexane (1:2) yielding the product of this example as a yellow solid, m.p. 72-75 C.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51171-02-9.

Application of 313339-92-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

2,3-Dichloro-N-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-phenyl]-benzenesulfonamide (5.78 g) was added to a reaction vessel containing a magnetic stirring bar together with 3,5-dichloro-pyrazine-2-carbonitrile (2.35 g), 1,1′- bis(diphenylphosphino)ferrocene-palladium(ll) dichloride (Pd(dppf)2Cl2) (791 mg) and cesium carbonate (13.2 g), followed by 100 ml dioxane and 10 ml water, and the mixture heated to 100 C under stirring. After 3 h the reaction mixture was cooled to RT and quenched with a saturated aqueous sodium bicarbonate solution (100 ml) and extracted with EtOAc (3 x 200 ml). The combined aqueous phases were dried over sodium sulfate, filtered and evaporated to afford the crude product as a brown oil. Purification by flash chromatography on silica gel using a mixture of EtOAc and heptane as the eluent afforded 2,3-dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2yl)- phenyl]-benzenesulfonamide as a light brown foam after evaporation of the solvents under reduced pressure. Yield: 4.32 g (73%). MS (ES-): m/e = 436.0 (M-H).

The synthetic route of 3,5-Dichloropyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Electric Literature of 5049-61-6, These common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Amino-5-bromopyrazine (15).; To a cooled solution of 2-aminopyrazine 11 (2.00 g, 21.00 mmol) in dichloromethane (50 mL) N-bromosuccinimide (NBS) (3.73 g, 21.00 mmol) was added in portion. The mixture was stirred at 0 0C for 2h and washed with Na2CO3 s.s. and water, the organic layer was dried over Na2SO4, filtered and the solvent removed under reduced pressure to get 2.80 g of the title compound 15 (77% yield) as an orange solid without further purification (mp 105-110 0C). 1H-NMR (CDCl3): 4.61 (br s, 2H), 7.75 (s, IH), 8.07 (s, IH). MS (GC-MS): m/z 174 .

Statistics shows that Pyrazin-2-amine is playing an increasingly important role. we look forward to future research findings about 5049-61-6.

Application of 313339-92-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a reaction vessel containing a magnetic stir bar was added 2,3-dichloro-N- [4- (4,4,5,5-tetramethyl- [1,3,2] dioxaborolan-2-yl) -phenyl] The amide (5.78 g) was added to a solution of 3,5-dichloro-pyrazine-2-carbonitrile (2.35 g), 1,1′-bis (diphenylphosphino) ferrocene-palladium (II) dichloride (Pd (dppf) 2 Cl 2) (791 mg) and cesium carbonate (13.2 g), followed by 100 ml of dioxane and 10 ml of water and the mixture was heated to 100 C. with stirring.After 3 h, the reaction mixture was cooled to room temperature and quenched with saturated aqueous sodium bicarbonate solution (100 ml) and extracted with EtOAc (3 × 200 ml). The combined aqueous phases were dried over sodium sulfate, filtered and evaporated to give the crude product as a brown oil. After purification by flash chromatography on silica gel using a mixture of EtOAc and heptane as eluent and evaporation of the solvent under reduced pressure, 2,3-dichloro-N-[4-(6-chloro-5-cyano-pyrazin-2yl)-phenyl]-benzenesulfonamide. Yield: 4.32 g (73%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Related Products of 109838-85-9,Some common heterocyclic compound, 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, molecular formula is C9H16N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00374] 100 g (0.543 mol) of 1 (100 g, 5.4 mol) was taken up in THF (1000 mL) and cooled to -78 ¡ãC. 228 mL (0.570 moles) of n-BuLi (2.5M in THF) was added dropwise over 30 minutes. Then the solution was stirred vigorously for an additional 30 minutes. 81 g of methyl iodide (0.57 mol) was diluted to 250 mL with THF and cooled to -78 ¡ãC. The methyl iodide was then added dropwise over 30 minutes. Following completion of the addition of methyl iodide, the reaction was stirred at -78 ¡ãC for 2 hours. 1L of diethyl ether was then added to the mixture, followed by 500 mL of H20. The reaction was then warmed to room temperature. The aqueous layer was extracted multiple times with diethyl ether and the organic layer were combined, washed with saturated sodium thiosulfate, once with brine, and dried over MgSC>4. The organics were concentrated under vaccum to give residue which was purified by chromatography with gradient of 50: 1 to 20: 1 petroleum ether: diethyl ether to yield 110 g (80.5percent) of 2 (pale yellow oil). XH NMR: (400 MHz, CDC13-J) ppm 0.60 – 0.72 (m, 3 H), 0.94 – 1.03 (m, 3 H), 1.26 – 1.35 (m, 3 H), 2.07 – 2.30 (m, 1 H), 3.53 – 3.70 (m, 6 H), 3.89 (br. s., 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, its application will become more common.

Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; VERDINE, Gregory, L.; HILINSKI, Gerard; WO2014/159969; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 13134-38-8, These common heterocyclic compound, 13134-38-8, name is 3,6-Dimethylpyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0093] To a stuffed solution of 280 mg (2.0 mmol) of thiophene-2,5-dicarbaldehyde in 6 mL of THF and 0.2 mL of water was added sodium borohydride (54 mg, 1.4 mmol). The reaction was stirred for 20 mm at rt. Water (5 mL) was added and the mixture was stirred for 10 mm and extracted with EtOAc (3 x). The combined organic layers were dried over Na2504, filtered and evaporated. The crude material was diluted with 10 mL of acetonitrile and cooled to 0 C. Triethylamine (0.89 mL) and methanesulfonyl chloride (0.40 mL) were added and the mixture was stilTed for 1 h at 0 C and then 1 h at rt. The mixture was treated with satd. aq. NaHCO3 and extracted with EtOAc (3 x). The combined organic layers were dried over Na2SO4, filtered and evaporated to provide 657 mg of crude thiophene-2,5-diylbis(methylene) dimethanesulfonate. A mixture of 62.1 mg of the crude mesylate, 114 mg of K2C03, and 50 mg of 3,6-dimethylpyrazin-2-amine in 1 mL of DMF was heated at 110 C in a sealed tube with stirring for 48 h. The mixture was cooled to rt, diluted with water, and extracted with EtOAc (3x). The combined organic layers were dried over Na2SO4, filtered and evaporated. Purification by column chromatography (100% EtOAc) provided 7.3 mg of the title compound. MS (ESj:[M+H] 355.3; [M+Na] 377.4; MS (ES): [M-H] 353.3.

The synthetic route of 13134-38-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; (53 pag.)WO2016/40780; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem