Pyrazines

Synthetic Route of 68236-03-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68236-03-3, name is 6-Chloropyrido[2,3-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 4.3 : 6-Vinvl-pyrido[2.3-blpyrazine (Scheme 10); 6-chloropyrido[2,3-b]pyrazine (Intermediate 4.2) (3 g, 18.12 mmol, 1.00 eq.) was dissolved in THF (150mL) and degassed with nitrogen at rt for 10 minutes. Tetrakis (triphenylphosphine) palladium(O) (1.46 g, 1.27 mmol, 0.07 eq.) and vinyltributylstannane (7.47 mL, 23.5 mmol, 1.3eq.) were added and reaction mixture was stirred at 65C for 3 hours. THF was evaporated and crude purified directly by flash chromatography using cyclohexane/ethyl acetate (8/2) to give 2.3 g of the expected compound (Intermediate 4.3) as an orange oil. Amount: 2.3g; Yield: 81%; Formula: C9H7N3; HPLC Purity: 98%; HPLC (HzO TFA 0.1%-ACN TFA Q.05%): Rt (min); Area % = 1.32 min; 98%; 1H NMR (DMSO-d6) 8 9.10 (s, 1H), 8.98 (s, 1H), 8.46 (d, 1H, J=8Hz), 7.95 (d, 1H, J= 8Hz), 6.90 (dd, 1H, Jtrans^HHz, Jcis= 10Hz), 6.50 (dd, 1H, Jt^nHz, Jgem=1.5Hz), 5.80 (dd, 1H, Jcis=10Hz, Jgem=1.5Hz). LC-MS:M/ZESI: Rt (min) 0.78 min, 158.13 (M+l).

The synthetic route of 6-Chloropyrido[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.

Synthetic Route of 14508-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14508-49-7, name is 2-Chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A flame dried and cooled 100 mL round bottom flask was charged with 2,2,6,6-tetramethylpiperidine (2.5 mL, 14.96 mmol) and anhydrous THF (25 mL) under a nitrogen atmosphere. The contents were cooled to -78 C. and n-butyllithium (2.5 M in hexane, 5.7 mL, 14.28 mmol) was added dropwise over a 5 minute period. The reaction mixture was stirred at -78 C. for 5 minutes, bought to 0 C. and stirred at 0 C. for 25 minutes. The reaction mixture was recooled to -78 C. and 2-chloropyrazine (0.78 g, 1 mL, 6.8 mmol) was added over a 3 minute period. After 30 minutes at -78 C., anhydrous DMF (0.99 mL, 13.6 mmol) was added over 3 minutes and the contents stirred at -78 C. for a further 30 minutes. The reaction mixture was bought to 0 C., stirred at 0 C. for 15 minutes, recooled to -78 C. and quenched by the addition of acetic acid (4 mL) in THF (10 mL). The reaction mixture was stirred at room temperature for 10 minutes and partitioned between ethyl acetate (60 mL) and brine (30 mL). The ethyl acetate layer is separated, dried over sodium sulfate, concentrated under reduced pressure and purified by silica gel flash chromatography using dichloromethane and ethyl acetate (9.5:0.5, 400 mL) to yield the title compound a (950 mg). 1H-NMR of the compound was consistent with the desired structure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloropyrazine, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 3-Bromo-2-pyrazinecarboxylate

A solution of 3-bromopyrazine-2-carboxylic acid methyl ester (0.10 g, 0.45 mmol), 2- tritylsulfanylethylamine (0.29 g, 0.90 mmol) and triethylamine (0.06 mL, 0.44 mmol) in acetonitrile (5 mL) was heated to reflux for 18 h under argon. The mixture was concentrated under reduced pressure and purified by column chromatography (3:1 Hex:EtOAc), yielding 0.058 g (28%) of the desired product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51171-02-9.

Application of 762240-92-6,Some common heterocyclic compound, 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, molecular formula is C6H8ClF3N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 50 mL round-bottom flask was added 20 mL dichloromethane, followed by the addition of phenyl-butyric acid derivative (3.37 g, 0.01 mol) and triazolopyrazine hydrochloride (228 g, 0.01 mol). The temperature of the reaction mixture was cooled down to 0 C. in an ice-salt bath. 1-Hydroxylbenzotriazole (1.62 g, 0.012 mol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.29 g, 0.012 mol) were further added. 3 g Triethylamine was then added dropwise and the mixture was stirred at room temperature for 24 h. The reaction solution was washed with 3×20 mL distilled water. The obtained organic layers were collected and dried over anhydrous magnesium sulfate for 1 h. Then, the desiccant was filtered off and the resulting reactant was concentrated to 4.7 g. The yield was 92%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., category: Pyrazines

A I L three-necked round bottom flask was charged with pyrazin-2-amine (20 g, 0.21 mol), DMSO (600 mL) and water (15 mL). To the above was added in portions N-Bromosuccinimide (77.9 g, 0.44 mol) while keeping the inner temperature below 5 C. The resulting mixture was stirred at 20 C overnight. The solvent was evaporated and the residue was purified by flash columnchromatography on silica gel with a 1 :10 EtOAc/petroleum ether, to afford 18 g (34%) of the product as a yellows solid. *H NMR (300 MHz, CDC13) delta: 8.02 (s, 1H), 4.72 (br, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 122-05-4

General procedure: 3.1.1.12; 2,5-Bis[6-(4,5-dihydro-1H-imidazol-2-yl)1,3-benzothiazol-2-yl]pyrazine dihydrochloride (3l) To a solution of the free base prepared by method A in acetic acid (40 mL) concd HCl (2.0 mL) was added and stirred for 2 h. The resulting precipitate was filtered off, washed with acetone and dried. Crystallization from water/1 M HCl/acetone mixture gave pure compound 3l 136 mg (46.0%) as yellow solid: mp > 300 C. 1H NMR (300 MHz, DMSO-d6) (delta ppm): 10.65 (br s, 4H, H-Amd), 9.70 (s, 2H, H-Pyr), 8.86 (d, 2H, J = 1.4 Hz, H-Bt), 8.48 (d, 2H, J = 8.7 Hz, H-Bt), 8.10 (dd, 2H, J = 1.5 Hz, J = 8.6 Hz, H-Bt), 4.06 (s, 8H, H-CH2). LC-MS (ESI) m/z: 483.3 [(M + H+) calcd for free base C24H18N8S2, 482.11]. Analysis calcd for C24H20Cl2N8S2 * 2H2O (591.54): C, 48.73; H, 4.09; N, 18.94, Cl, 11.99. Found C, 48.91; H, 4.05; N, 18.94; Cl, 11.72%.

The synthetic route of 122-05-4 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 58139-03-0, name is 2-Iodo-6-methoxypyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H5IN2O

1. 3-[2-(6-Methoxypyrazin)yl]-3-hydroxy-1-azabicyclo-[2.2.1]heptane t-Butyllithium (24 ml of a 1.7M solution in pentane, 40.8 mmol) was added dropwise to a rapidly stirred solution of 2-iodo-6-methoxypyrazine (4.7 g, 19.9 mmol) in ether (125 ml), at -50° C. The reaction mixture was stirred for 0.25 h and a solution of 1-azabicyclo[2.2.1]heptan-3-one (2.86 g, 25.8 mmol) in ether (20 ml) (predried over MgSO4), then added and warmed to room temperature. Aqueous workup and extraction into dichloromethane gave the crude product which was chromatographed on alumina using dichloromethane/methanol (96:4) as eluant to give the title alcohol (2.91 g) as a yellow oil; (Found: M+ =221.1166; C11 H15 N3 O2 requires M+ =21.1164); m/e 221 (M+); delta(250 MHz, CDCl3) 1.46-1.62 (1H, m, CH of CH2); 2.26-2.40 (1H, m, CH of CH2); 2.50 (1H, dd, J=3.5 and 12 Hz, CH of CH2 –N); 2.60 (1H, dd, J=4.5 and 14 Hz, CH of CH2 –N); 2.72 (1H, d, J=4.5 Hz, CH-bridgehead); 2.74-3.06 (2H, m, CH2 –N); 3.07-3.14 (1H, m, CH of CH2 –N); 3.42 (1H, dd, J=1.5 and 14 Hz, CH of CH2 –N); 3.96 (3H, s, OMe); 8.13 (1H, s, pyrazine-H); 8.37 (1H, s, pyrazine-H).

The synthetic route of 2-Iodo-6-methoxypyrazine has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 59489-71-3, name is 2-Amino-5-bromopyrazine, molecular formula is C4H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 59489-71-3

Preparation 10: 2-Bromo-5-iodopyrazineTo a solution of 5-bromopyrazin-2-amine (25.95 g, 147.13 mmol) in 1 ,2-dimethoxyethane (500 ml_) was added cesium iodide (38.75 g, 147.13 mmol), copper (I) iodide (8.52 g, 44.74 mmol) and iodine (18.93 g, 74.57 mmol). Isoamyl nitrite (120 ml_, 894.8 mmol) was then added dropwise via a dropping funnel and the reaction mixture was heated at 60 C for 1 hour. After this time, the mixture was cooled to room temperature and diluted with ethyl acetate (200 ml_), washed with ammonium chloride (sat. aq .200 ml_), then sodium thiosulphate (sat. aq.3 x 200 ml_). The organic layer was dried over MgS04, filtered and the solvent was evaporated under reduced pressure. The crude product was purified by silica column (heptane : ethyl acetate, 100:0 to 85:15) to give the title compound as a off-white solid (35.38 g).LCMS (run time = 5 minutes, System D): Rt = 2.09 minutes.H NMR (400 MHz, CDCI3): delta = 8.65 (s, 1 H), 8.50 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 59489-71-3, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4ClN3O

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 61655-77-4, These common heterocyclic compound, 61655-77-4, name is 2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reaction Scheme 12EXAMPLE 43 : 1 -(4-methoxybenzyl)-3 -methyl-5 -(6-(4-methylpiperazin- 1 -yl)pyrazin-2- yP- 1 H-pyrazolo [3 ,4-b”|pyridineTo a stirred solution of 8 and 63 in 1,4 dioxane and water was added CS2CO3, the solution degassed, purged with nitrogen for 15 min, Pd(PPh3)4 was added and the reaction mass was again purged with nitrogen for another 15 min. The reaction mass was heated at 100C in a sealed tube overnight. After completion of the reaction the reaction mass was partitioned between ethyl acetate and water and the organic layer was separated and again extracted with ethyl acetate. The combined organic layer was dried over sodium sulphate and the solvent completely distilled off to get the crude. The crude was passed through 100-200 mesh silica gel eluting the pure compound at 70-80% ethyl acetate in hexane as off white coloured solid compound 64 (25 mg).

The synthetic route of 61655-77-4 has been constantly updated, and we look forward to future research findings.