Pyrazines

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13924-95-3 as follows. Recommanded Product: Methyl 5-hydroxypyrazine-2-carboxylate

Step 1: methyl 6-bromo-5 (0596) To a solution of methyl 5-hydroxypyrazine-2 carboxylate {Ark Pharm, cat24812: 145 mg, 0.94 mmol) in N, N-dimethylformamide (4 mL) was added N-bromo (0597) succinimide (200 mg, 1.13 mmol) at 0 C. The resulting mixture was stirred at room temperature for 5 h then quenched by NaHCC solution. The mixture was concentrated and the residue was purified by column chromatography (gradient, 0-80% MeOH in DCM) to give the desired product. LC-MS calculated for CeHeBr^Cb (M+H)+: m/z = 233.0; found 232.9.

According to the analysis of related databases, 13924-95-3, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 117719-17-2, Recommanded Product: 117719-17-2

Compound 10 (6.5 g, 25.086 mmol, 1.0 equiv) and ethyl bromopyruvate (3.462 mL, 27.595 mmol, 1.1 equiv) were mixed in the minimum amount of dimethoxyethane (DME). The mixture was refluxed for 20 h. The solvent was evaporated and the residue was purified by automated chromatography (Biotage, EtOAc in cyclohexane, 5-10%) to yield 3.086 g of compound 11 (35% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-3-morpholinopyrazin-2-amine, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-08-0, name is 2-Methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H6N2

(1) Under the protection of nitrogen,A 2-methyl pyrazine in a molar ratio of 1: 0.05: 1.2,Dibenzoyl peroxide and N-chlorosuccinimide were added to the solvent anhydrous carbon tetrachloride, A-chloromethylpyrazine by refluxing;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 109-08-0.

Electric Literature of 6863-73-6, These common heterocyclic compound, 6863-73-6, name is 3-Chloropyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 48% aqueous hydrogen bromide solution (0.893 mL) and water (9 mL), 2-bromo-1,1-diethoxyethane (5.98 mL, 38.5 mmol) was added, and stirred for one hour while heating under reflux. To the reaction solution, water and ethyl ether were added to separate phases. The water phase was extracted with ethyl ether and organic phases were combined, dried over magnesium sulfate, filtrated and concentrated under reduced pressure. To the resultant residue and a dimethoxyethane (22 mL) solution of 3-chloropyrazine-2-amine (2.0 g, 15.4), a 48% aqueous hydrogen bromide solution (0.3 mL) was added, stirred for 3 hours while heating under reflux. The resultant solid substance was obtained by filtration and washed with ether to obtain 8-chloroimidazo[1,2-a]pyrazine (2.07 g, 88%) as a black solid substance.MS (ESI) m/z=154 (M+H)+.

The synthetic route of 6863-73-6 has been constantly updated, and we look forward to future research findings.

55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C5H2ClN3

iv) (+-)-3-[(6R,9aS)-6-(hydroxymethyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]pyrazine-2-carbonitrile (+-)-(6R,9aS)-Octahydro-2H-pyrido[1,2-a]pyrazin-6-ylmethanol (500 mg, 2.93 mmol) was dissolved in THF (7 mL) and Et3N (2.03 mL, 14.7 mmol). 3-Chloropyrazine-2-carbonitrile (573 mg, 4.11 mmol) was added with stirring, and the reaction was stirred overnight at 35 C. The reaction mixture was then diluted with DCM and washed with water. The organic phase was purified by column chromatography to yield the desired product (650 mg, 81%). 1H NMR (300 MHz, CDCl3): delta (ppm) 1.40 (m, 1H); 1.69 (m, 4H); 1.82 (m, 1H); 2.21-2.32 (m, 4H); 2.93 (dd, 1H); 3.28 (m, 2H); 3.35 (d, 1H); 3.96 (dd, 1H); 4.34 (d, 1H); 4.48 (d, 1H); 8.02 (d, 1H); 8.26 (d, 1H).

The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, COA of Formula: C4H5ClN4

Add intermediate b (5.0 g, 0.034 mol) to triethyl orthoacetate (50 mL),The reaction was performed at 80 C, and the reaction time was monitored by spotting. The reaction liquid is directly filtered by cold suction,The filter cake was washed with petroleum ether, and the filter cake was dried to obtain 4.9 g of a yellow powder.The yield was 84.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Application of 122-05-4, These common heterocyclic compound, 122-05-4, name is Pyrazine-2,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Diacid 64 was prepared from the corresponding pyrazine 82. Synthesis of pyrazine-2,5-dicarboxylic acid 82 had been reported by several authors.

Statistics shows that Pyrazine-2,5-dicarboxylic acid is playing an increasingly important role. we look forward to future research findings about 122-05-4.

36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C5H2ClN3

The tert-butyl 4-(5-cyanopyrazin-2-yl)piperazine-1-carboxylate required for the synthesis was prepared in the following manner: To a solution of 5-chloropyrazine-2-carbonitrile (200 mg, 1.43 mmol) and tert-butyl piperazine-1-carboxylate (266.95 mg, 1.43 mmol) in anhydrous DMA (5 ml) under N2 was added DIPEA (748.95 muL, 4.3 mmol). The mixture was stirred and heated at 150C in a microwave for 90 mins. The mixture was allowed to cool to RT, prior to adding water until a significant amount of precipitate was observed. This was filtered under vacuum, washed with water and dried to afford 363mg, 87% of titled compound as a light brown solid. METCR1673 Generic 2 minutes M/Z (ES+) 233.9, Retention time 1.28. 1H NMR (500 MHz, DMSO-d6) delta 8.35 (d, J = 1.3 Hz, 1H), 8.12 (d, J = 1.3 Hz, 1H), 3.78 – 3.71 (m, 4H), 3.61 – 3.55 (m, 4H), 1.49 (s, 9H).

The synthetic route of 36070-75-4 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

3.0 g of intermediate V (4.5 mmol) was dissolved in 25 mL of DMF,2.06 g of EDC.HCl (10.8 mmol) and1.46 g of HOBT (10.8 mmol) followed by 1.80 g of starting material X (9.0 mmol) and 1.30 mL of triethylamine (9.0 mmol)Stirred at room temperature for 15 h,Add water to extract the reaction,Ethyl acetate extraction, organic NaHCO3 aqueous solution and saturated brine,No waterNa2SO4. The solvent was evaporated under reduced pressure and the column chromatography (EtOAc / petroleum ether = 7: 3) gave the product as a white solid intermediate

The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guizhou University; Liu Xiongli; Tian Minyi; Yao Zhen; Liu Xiongwei; Zhang Min; Zhou Ying; Feng Tingting; Yu Zhangbiao; (6 pag.)CN107129501; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6,8-Dibromoimidazo[1,2-a]pyrazine

In a 250 mL round bottom flask equipped with a condenser was placed 6,8-dibromoimidazo[l,2-a]pyrazine (2000 mg, 7.22 mmol) and added 30 mL isopropanol followed by Nu,Nu-diisopropylethylamine (2.52 ml, 14.44 mmol) and (R)-(4-(4- aminophenyl)mo holin-2-yl)methanol (1504.12 mg, 7.22 mmol). The reaction was heated to reflux (oil bath 95 C) overnight. The reaction was cooled and precipitates were collected by filtration and washed with isopropanol followed by hexanes to give the desired compound XVII.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 63744-22-9, its application will become more common.

Reference:
Patent; GILEAD SCIENCES, INC.; DI PAOLO, Julie, A.; LIN, Joseph, Haw-Ling; LIN, Shao-Lee; (86 pag.)WO2016/172117; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem