Pyrazines

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H3ClN2O2

Preparation Example 6 5-Chloropyrazine-2-carboxylic acid (3.00 g), N,N-dimethylformamide (30 mL), ethyl piperidine-4-carboxylate (5.83 mL), and diisopropylethylamine (6.50 mL) were mixed, followed by stirring at 80C overnight. The reaction mixture was cooled to room temperature and ethyl acetate was added thereto. The mixture was washed with an aqueous citric acid solution, water, and a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate. The insoluble materials were then separated by filtration and the filtrate was concentrated under reduced pressure. The obtained solid was washed with diisopropyl ether and dried to obtain 5-[4-(ethoxycarbonyl)piperidin-1-yl]pyrazine-2-carboxylic acid (3.96 g) as a solid.

According to the analysis of related databases, 36070-80-1, the application of this compound in the production field has become more and more popular.

16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of Methyl 2-aminopyrazine-3-carboxylate

Acetonitrile (500 mL), Compound 1 (100 g, 0.653 mol), and NCS (87.2 g, .653 mol) were added to a 1 L three-necked flask and the mixture was heated to 82°C for 12 hours to complete the reaction. Acetonitrile was concentrated and removed, and recrystallized from petroleum ether/ethyl acetate to give a bright green crystalline Compound 2 (112.7 g, 92percent).

The synthetic route of 16298-03-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 91476-80-1,Some common heterocyclic compound, 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 2 5-[5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-3-(2-fluorophenyl)-[1,2,3]triazolo[1,5-a]quinazoline Prepared from 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine as described for Example 1, step c (0.020 g, 23%). deltaH (360 MHz; CDCl3) 4.12 (2H, dd, J=6 and 6), 4.41 (2H, dd, J=6 and 6), 5.02 (2H, s), 6.93 (1H, s), 7.07 (1H, s), 7.21-7.32 (2H, m), 7.36-7.40 (1H, m), 7.68 (1H, dd, J=7 and 7), 7.95 (1H, dd, J=7 and 7), 8.07-8.10 (2H, m), 8.73 (1H, d, J=8); m/z (ES+) 386 (M+H+).

The synthetic route of 91476-80-1 has been constantly updated, and we look forward to future research findings.

Reference of 21279-64-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

The chemical industry reduces the impact on the environment during synthesis 5-Chloropyrazine-2-carboxamide. I believe this compound will play a more active role in future production and life.

Synthetic Route of 313339-92-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

3,5-Dichloropyrazine-2-carbonitrile (24 mg, 0.138 mmol), 6-cyclopropyl-2-[(2R,3R)-2- methylpiperidin-3-yl]-1,2-dihydroisoquinolin-1-one (36 mg, 0.118 mmol) and DIEA (0.050 mL, 0.287 mmol) were dissolved in EtOH (2.5 mL) and stirred at 40 C for 100 minutes. The reaction was quenched with aqueous NH4Cl. DCM was added and the mixture was filtered through a phase separator. The organic layer was concentrated under high vacuum and the residue was purified by silica flash chromatography with 0% to 40% of ethyl acetate in cyclohexane to give 3-chloro-5-[(2R,3R)-3-(6-cyclopropyl-1-oxo-1,2-dihydroisoquinolin-2-yl)- 2-methylpiperidin-1-yl]pyrazine-2-carbonitrile (39 mg, 79% yield) as a white solid. MS found for C23H22ClN5O as (M+H)+ 420.1.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dichloropyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H6N4

1003301 Step A: 2-(5-methyl-4-nitroso-3-phenyl-1H-pyrazol-i-yl)pyrazine. To a solution of 2-hydrazinylpyrazine (0.485 g, 4.40 mmol) in HOAc (6 mL) was added (2- (hydroxyimino)-i-phenylbutane-i,3-dione (0.765 g, 4.00 mmol) in small portions over 2 minutes. The mixture was stirred for 5 minutes and the resulting light orange suspension was stirred at 60 C for 6 hours. EtOH (1 mL) was added and the mixture was heated at 60 C for an additional 6 hours. The resulting dark green suspension was cooled to ambient temperature and the mixture was diluted with H20 (30 mL). The green suspension was stirred for 1 hour and the solid was collected via vacuum filtration. The collected solid was washed with 1120 and dried in vacuum. The solid was suspended in EtOH (25 mL) and concentrated HC1 (500 jiL) was added. The mixture was heated at reflux for 20 hours, cooled to ambient temperature and diluted with chilled 1120 (75 mL). The mixture was treated with 1M NaOH to pH=7 and was extracted with Et20 (3X). The combined extracts were washed with saturated NaC1 and dried over MgSO4. The dried solution was filtered through packed Celite and concentrated. The residual green-yellow solid was purified on a Si02 column using step gradient elution (25% CH2C12, 50% EtOAc/hexanes) to furnish the title compound as a turquoise solid (325 mg, 3 1%). MS (apci) mlz = 266.1 (M+H).

The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.

Reference of 2423-65-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2423-65-6, name is Pyrazine 1-oxide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.; 2-(Naphthalen-1-yl)pyrazine N-oxide (Table 4, entries 2, 13 and 14) Synthesised according to general procedure 2 employing the corresponding aryl bromide and chloride. Purification via silica gel column chromatography using 100% DCM then a mixture of 10% Acetone/DCM gave a brown oil, 89% from the bromide and 60% from the chloride. 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.61 (1H, s), 8.48 (1H, d, J=3.9 Hz), 8.26 (1H, d, J=4.2 Hz), 8.00 (1H, d, J=7.8 Hz), 7.93-7.87 (1H, m), 7.59-7.37 (5H, m). 13C NMR (75 MHz, CDCl3, 293K, TMS): 150.1, 147.1, 145.7, 134.8, 133.9, 131.5, 131.3, 129.2, 128.9, 127.6, 127.0, 125.7, 125.3. HRMS calculated for C14H10N2O1 (M+) 222.0793; Found: 222.0775. IR (vmax/cm-1): 3057, 3010, 2923, 2853, 1578, 1301, 873, 801, 776.

The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121246-96-6 as follows. Application In Synthesis of 3-Chloropyrazine-2-carbaldehyde

Add in pressure reactor3-Chloro-2-carbaldehyde pyrazine (II)(0.71 g, 5 mmol) and dioxane (20 mL),Ammonia (1.7g, 0.1mol) was added with stirring and then added4- (Pyridin-2-yl-Aminocarbonyl) benzeneboronic acid(III) (2.42 g, 10 mmol),Acetylacetonate dicarbonyl rhodium(0.26 g, 1 mmol) and water 4 mL.The reactor closed, gradually warming to 80 ~ 90 degrees,The reaction 16-18 hours, TLC detection, the reaction was completed.Concentration under reduced pressure, the residue was dissolved with methylene chloride,Saturated sodium bicarbonate and water were washed in turn, dried over anhydrous sodium sulfate.Concentrated to give a tan oil,Column chromatography with ethyl acetate and petroleum ether (1: 2 by volume) gave a white solid4- [amino (3-chloro-2-pyrazinyl)Methyl] -N- (2-pyridyl)Benzamide(IV) 1.38 g, 81.2% yield

According to the analysis of related databases, 121246-96-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, A new synthetic method of this compound is introduced below., COA of Formula: C6H8ClF3N4

Into a 50 mL round-bottom flask was added 20 mL acetonitrile, followed by the addition of the phenyl-butyric acid derivative obtained in Example 46 (3.32 g, 0.01 mol) and triazolopyrazine hydrochloride (228 g, 0.01 mol). The temperature of the reaction mixture was cooled down to 0 C. in an ice-salt bath. 1-Hydroxylbenzotriazole (1.62 g, 0.012 mol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.29 g, 0.012 mol) were further added. 3 g Triethylamine was then added dropwise and the mixture was stirred at room temperature for 24 h. The reaction solution was washed with 3 X 20 mL distilled water. The obtained organic layers were collected and dried over anhydrous magnesium sulfate for 1 h. Then, the desiccant was filtered off and the resulting reactant was concentrated to 4.81 g. The yield was 95%. [alpha] D20=+22.2 (c 1.0, CHCl3). M.p. 188-191 C. IR (cm-1): 3374, 2897, 1686, 1635, 1519, 1368, 1164, 1128, 1016. 1H NMR (400 MHz, CDCl3) delta 7.187.05 (m, 1H), 7.02-6.85 (m, 1H), 5.31 (s, 1H), 5.154.76 (m, 2H), 4.433.78 (m, 5H), 2.982.92 (m, 2H), 2.712.61 (m, 2H), 1.36 (s, 9H). ESI-MS: 508.0 (M++1). HRMS Calcd. for: C21H23F6N5O3Na (M+Na)+ requires 530.1598, found 530.1604.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 41110-33-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41110-33-2 name is Methyl 5-methylpyrazine-2-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0115j To a solution of methyl 5-methylpyrazine-2-carboxylate (0.5 g, 3.28 mmol) in acetic acid (5 ml) was added bromine (0.i9 ml, 3.6i mmol) at room temperature. The reaction mixture was heated at 80C for 45 mm. The reaction mixture was concentrated to remove acetic acid. The residue was basified with saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried and concentrated. The crude was purified by silica gel column chromatography using 20% ethyl acetate in hexane to afford the title compound methyl 5-(bromomethyl)pyrazine-2-carboxylate (0.3 g, 40%) as a brownish liquid. Calculated M+H: 230.97; Found M+H: 231.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-methylpyrazine-2-carboxylate, and friends who are interested can also refer to it.