Category: Pyrazines

Application of 74290-67-8,Some common heterocyclic compound, 74290-67-8, name is 2-Amino-5-bromo-3-methylpyrazine, molecular formula is C5H6BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of 5-bromo-3-methylpyrazin-2-amine (4.63g, 24.6 mmol) in iPrOH (30 ml) was added l-bromo-2,2-dimethoxypropane (3.66 ml, 27.1 mmol), pyridinium para-toluene sulfonic acid (0.62g, 2.5 mmol) and the mixture heated to 65C in a sealed tube for 36h. The reaction was diluted with DCM, washed with saturated sodium hydrogen carbonate solution, dried (Na2S04) and concentrated. Purification by flash column chromatography on silica gel (EtOAc: Hept 1:4-1: 1) afforded the titled product as a light yellow crystalline solid (3.96 g, 71%). MS (m/e): 226.1 (M+H+, Br)

The synthetic route of 74290-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GREEN, Luke; PINARD, Emmanuel; RATNI, Hasane; WILLIAMSON, Patrick; (95 pag.)WO2015/197503; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H6BrN3O

(+/-)-l-(3,5-dichlorophenyl)-2,2,2-trifiuoroethane-l-sulfonyl chloride (165 mg, 0.48 mmol) was added to a solution of 5-bromo-3-methoxypyrazin-2-amine (107 mg, 0.53 mmol) in anhydrous pyridine (5 mL) The reaction was sealed under nitrogen and stirred at room temperature for 60 min then at 60 C for 45 min. The reaction was allowed to cool to room temperature then concentrated in vacuo. The residue was purified over silica (Biotage 10 g SNAP cartridge) eluted with Heptane:EtOAc 1 :0 to 8:2 to 6:4 to 4:6 to afford the title compound (20 mg, 7%) as a light brown solid. H NMR (500 MHz, CDCls) delta 4.06 (s, 3H), 5.71 (q, 1H), 7.36 (br.s, 1H), 7.46 (d, 2H), 7.49 (m,lH), 8.03 (s, 1H).

The synthetic route of 5-Bromo-3-methoxypyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In an article, author is Chen, Qi, once mentioned the application of 20737-42-2, HPLC of Formula: C5H4N2O3, Name is 3-Oxo-3,4-dihydropyrazine-2-carboxylic acid, molecular formula is C5H4N2O3, molecular weight is 140.0969, MDL number is MFCD00235136, category is Pyrazines. Now introduce a scientific discovery about this category.

The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism

Background: Heart failure (HF) is one of the most common causes of cardiovascular diseases in the world. Currently, the drugs used to treat HF in the clinic may cause serious side effects. Liguzinediol, 2, 5-dimethyl-3, 6-dimethyl-pyrazine, is a compound synthesized after the structural modification of ligustrazine (one active ingredient ofSzechwan Lovage Rhizome). We aimed to observe the effects of liguzinediol on preventing HF and explore the related mechanisms. Methods: The ligation of left anterior descending coronary artery was operated to established the myocardial infarction (MI) model in Sprague-Dawley rats. Cardiac functions were recorded by echocardiography and hemodynamics. The changes in the Renin-Angiotensin-Aldosterone System (RAAS), inflammation, and oxidative stress were detected by radioimmunoassay and Elisa kits. Western blot and real-time PCR were applied to determine the expressions of the TGF-beta 1/Smads pathway. Results: Firstly, liguzinediol enhanced the systolic and diastolic functions of the heart in MI rats. Liguzinediol improved ventricular remodeling by reducing myocardial cell necrosis, as well as reducing collagen deposition and myocardial fibrosis. Then, liguzinediol suppressed the activation of RAAS, inhibited the synthesis of pro-inflammation factors, and reduced oxidative stress. In the end, liguzinediol also down-regulated the expressions of the TGF-beta 1/Smads pathway. Conclusions: Liguzinediol could alleviate HF caused by MI in rats, and the protective effect was associated with the regulation of the TGF-beta 1/Smads pathway.

If you are interested in 20737-42-2, you can contact me at any time and look forward to more communication. HPLC of Formula: C5H4N2O3.

Chemistry, like all the natural sciences, COA of Formula: C6H4N2O4, begins with the direct observation of nature¡ª in this case, of matter.89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a document, author is Pakyapan, Bilge, introduce the new discover.

Synthesis and catalytic applications of Ru and Ir complexes containing N,O-chelating ligand

A series of monometallic complexes (Ru1-3, Ir-1(-3)) which have N,O-chelating ligand (pyrazine-2carboxylate (1), pyridine-2-carboxylate (2), quinoline carboxylate(3) and bimetallic complexes (Ru-4,Ru-5, Ir-4(,5)) bridged by pyrazine-2,3- dicarboxylate (4) and imidazole-4,5-dicarboxylate(5) were synthesized and characterized by H-1-, C-13 NMR, FT-IR, and elemental analysis. The crystal structure of Ir-2 was determined by X-ray crystallography. The complexes (Ru1-5, Ir1-5) were applied to investigate the electronic and steric effect of ligand in their catalytic activities in transfer hydrogenation and alpha(alpha)-alkylation reaction of ketones with alcohols. The activities of iridium complexes (Ir1-5) were much more efficient than ruthenium complexes (Ru1-5). The highest activity for both reactions was observed for the complex (Ir2 ) with pyridine-2-carboxylate. The Ir hydride species was monitored for both reactions. (C) 2020 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 89-01-0. COA of Formula: C6H4N2O4.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 123-32-0, Name is 2,5-Dimethylpyrazine, SMILES is C1=NC(=CN=C1C)C, in an article , author is Wang, Dan, once mentioned of 123-32-0, Safety of 2,5-Dimethylpyrazine.

The 3D POMOFs based two As-III-capped Keggin arsenomolybdates with four V-IV substituted: Synthesis, structures and properties

A novel 3D POMOFs based As-III-capped Keggin arsenomolybdate with four V-IV substituted, [(As2AsMO8V4O40)-As-III-M-V-V-VI-O-IV](2)[(CuCu2II)-Cu-I(pz)(4)](2)center dot 9H(2)O (1) (pz = pyrazine) was prepared by hydrothermal method and characterized by elemental analysis, IR, TG, XPS, BET, Raman, optical band gap and XRD. Compound 1 represents the first polyoxometalate metal organic frameworks (POMOFs) based [(As2AsMO8V4O40)-As-III-M-V-V-VI-O-IV](5-) polyoxoanion and {Cu-pz} complex, which forms a 3D topological network with the Schlafli symbol of {5.6.8}{5(2).6.7.8(2)}{5(2).7(2).8(2)}{6.7.8}. Compound 1 displays excellent photocatalytic activity and stability for degradation methylene blue (MB), rhodamine-B (RhB), methyl orange (MO), and Azophloxine (AP) under UV light. The photodegradation reaction kinetic and mechanism of 1 were explored. In addition, the luminescence property of 1 was also investigated.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 123-32-0, you can contact me at any time and look forward to more communication. Safety of 2,5-Dimethylpyrazine.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.290-37-9, Name is Pyrazine, SMILES is C1=NC=CN=C1, belongs to Pyrazines compound. In a document, author is Kergreis, Angelique, introduce the new discover, Safety of Pyrazine.

Influence of Ligand and Nuclearity on the Cytotoxicity of Cyclometallated C boolean AND N boolean AND C Platinum(II) Complexes

A series of cyclometallated mono- and di-nuclear platinum(II) complexes and the parent organic ligand, 2,6-diphenylpyridine1((HCNCH)-N-boolean AND-C-boolean AND), have been synthesized and characterized. This library of compounds includes [((CNC)-N-boolean AND-C-boolean AND)Pt-II(L)] (L=dimethylsulfoxide (DMSO)2and triphenylphosphine (PPh3)3) and [(((CNC)-N-boolean AND-C-boolean AND)Pt-II)(2)(L’)] (whereL’=N-heterocycles (pyrazine (pyr)4, 4,4′-bipyridine (4,4′-bipy)5or diphosphine (1,4-bis(diphenylphosphino)butane (dppb)6). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes (4-6), when compared to the mononucleated species (2and3). Complex 6is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values >29.5 (A2780) and >11.2 (A2780cisR), and outperforming cisplatin by >4-fold and >18-fold, respectively.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 290-37-9 is helpful to your research. Safety of Pyrazine.

Application of 89-01-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 89-01-0, Name is Pyrazine-2,3-dicarboxylic acid, SMILES is O=C(C1=NC=CN=C1C(O)=O)O, belongs to Pyrazines compound. In a article, author is Contreras-Torres, Flavio F., introduce new discover of the category.

Dispersion-Corrected Density Functional Theory Study of the Noncovalent Complexes Formed with Imidazo[1,2-a]pyrazines Adsorbed onto Silver Clusters

Imidazo[1,2-a]pyrazines are cyclic amidine type compounds composed of alpha-amino acid residues. A full structural identification of these molecules constitutes an analytical challenge, especially when imidazo, [1, 2-a] pyrazines are obtained from physical processes (e.g., sublimation and pyrolysis of amino acids). A valuable source of molecular inforination can be obtained from absorption spectroscopies and related techniques encoinpassing the use of metallic substrates. The aim of this study is to provide new knowledge and insights into the noncovalent intermolecular interactions between imidazo[1,2-a]pyrazines and two Ag-n (n = 4 and 20) clusters using density functional theory (DFT) methods. Semiempirical DFT dispersion (DFT-D) corrections were addressed using Grimme’s dispersion (GD2) and Austin- Petersson Frisch (APF) functionals in conjunction with the 6-31+G(d,p) + LANL2DZ mixed basis set. These DFT-D methods describe strong interactions; besides, in all cases, the APF dispersion (APF-D) energies of interaction appear to be consistently overestimated. In comparison with B3LYP calculations, the mean values for the difference in the energies of interaction calculated are 2.25 (GD2) and 6.24 (APF-D) kcal mol(-1) for Ag-4(-) molecules, and 2.30 (GD2) land 8.53 (APF-D) kcal mol(-1) for Ag-20-molecules. The effect of applying GD2 and APF-D corrections to the noncovalent complexes is nuanced in the intermolecular distances calculated, mainly in the Ag center dot center dot center dot N(amidine) bonding, which appears to play the most important role for the adsorptive process. Selective enhancement and considerable red shifts for Raman vibrations suggest strong interactions, whereas a charge redistribution involving the metallic substrate and the absorbate leads to a significant rearrangement of frontier molecular orbitals mainly in the Ag-20-molecule complexes. Finally, time-dependent DFT calculations were carried out to access the orbital contributions to each of the transitions observed in the absorption spectrum. The corresponding UV-vis spectra involve transitions in the visible region at around 400 and 550 nm for the Ag-4-molecule and the Ag-20-molecule complexes, respectively.

Application of 89-01-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 89-01-0 is helpful to your research.

In an article, author is Abu-Melha, Sraa, once mentioned the application of 2847-30-5, Recommanded Product: 2-Methoxy-3-methylpyrazine, Name is 2-Methoxy-3-methylpyrazine, molecular formula is C6H8N2O, molecular weight is 124.1405, MDL number is MFCD00006127, category is Pyrazines. Now introduce a scientific discovery about this category.

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M-pro)

A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide 2 with various carbonyl compounds. Also, dehydrative-cyclocondensation of 2 with active methylene compounds or anhydrides gave the respective pyarzole or pyrazine derivatives. The structures of the newly synthesized compounds were established based on spectroscopic evidences and their alternative syntheses. Additionally, the anti-viral activity of all the products was tested against SARS-CoV-2 main protease (M-pro) using molecular docking combined with molecular dynamics simulation (MDS). The average binding affinities of the compounds 3a, 3b, and 3c (-8.1 +/- 0.33 kcal/mol, -8.0 +/- 0.35 kcal/mol, and -8.2 +/- 0.21 kcal/mol, respectively) are better than that of the positive control Nelfinavir (-6.9 +/- 0.51 kcal/mol). This shows the possibility of these three compounds to effectively bind to SARS-CoV-2 Mpro and hence, contradict the virus lifecycle.

If you are interested in 2847-30-5, you can contact me at any time and look forward to more communication. Recommanded Product: 2-Methoxy-3-methylpyrazine.

In an article, author is Tashiro, Keigo, once mentioned the application of 33332-25-1, Recommanded Product: Methyl 5-chloropyrazine-2-carboxylate, Name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, molecular weight is 172.57, MDL number is MFCD01632102, category is Pyrazines. Now introduce a scientific discovery about this category.

The formation mechanism of ZnTPyP fibers fabricated by a surfactant-assisted method

Fibers composed of 5,10,15,20-tetrakis(4-pyridyl)porphyrinatozinc(ii) (ZnTPyP) were synthesized by a surfactant-assisted method using cetyltrimethylammonium bromide (CTAB) and chloroform. The presence of CTAB was essential to make and to maintain the fibers and their formation rate became slower with increasing the molar ratio of CTAB to ZnTPyP. Measurements of absorption spectra of the synthesized fibers showed splitting of the Soret band at 426 nm into two peaks at 416 and 454 nm in accordance with the formation of the ZnTPyP fibers as revealed by transmission electron microscopy. The aging process at higher temperature made the fibers longer and the apparent activation energy for the formation of the fibers was estimated to be 74.8 kJ mol(-1). When 5,10,15,20-tetrakis(4-pyridyl)porphyrin (TPyP) or 5,10,15,20-tetrakis(phenyl)porphyrinatozinc(ii) (ZnTPP) was used instead of ZnTPyP, no fiber formation was observed. On the other hand, when a chloroform solution of ZnTPP was mixed with pyrazine or 4,4 ‘-bipyridine, the fiber formation was observed. Proton nuclear magnetic resonance spectra indicated upfield shifts of the pyridinic proton in the presence of ZnTPP and 4,4 ‘-bipyridine, suggesting the coordination of nitrogen to zinc(ii) (Zn-N) in ZnTPP. These findings indicate that the Zn-N coordination is crucial for the formation of the fibers and that nitrogen in the pyridyl moiety of ZnTPyP is coordinated to the central zinc(ii) ion of another ZnTPyP molecule to make the ZnTPyP fibers. Theoretical calculations were performed using the DFT/B97D functional to estimate the stability of the pi-pi stacking and the coordination of Zn-N. The presence of the CTAB micelles suppresses the aggregation of ZnTPyP molecules due to the pi-pi stacking, which is thermodynamically more favorable. The Zn-N coordination proceeds moderately during the aging process for 10 days by inducing the transition from spherical CTAB micelles to rod-like micelles by fusion.

If you are interested in 33332-25-1, you can contact me at any time and look forward to more communication. Recommanded Product: Methyl 5-chloropyrazine-2-carboxylate.

In an article, author is Regenauer, Nicolas, I, once mentioned the application of 89-01-0, Name: Pyrazine-2,3-dicarboxylic acid, Name is Pyrazine-2,3-dicarboxylic acid, molecular formula is C6H4N2O4, molecular weight is 168.11, MDL number is MFCD00006131, category is Pyrazines. Now introduce a scientific discovery about this category.

A Redox-Active Heterobimetallic N-Heterocyclic Carbene Based on a Bis(imino)pyrazine Ligand Scaffold

A new redox-active N-heterocyclic carbene (NHC) architecture is obtained using N-methylated pyrazinediimine iron complexes as precursors. The new species exhibit strong pi-accepting/sigma-donating properties and are able to ligate two metal centres simultaneously. The redox activity was demonstrated by the reversible chemical oxidation of a heterobimetallic Fe-0/Rh(I)example, which affords an isolable ligand-based radical cation. The reversible redox process was then applied in the catalytic hydrosilylation of 4,4 ‘-difluorobenzophenone, where the reaction rate could be reversibly controlled as a function of the catalyst oxidation state. The new NHC exhibits high electrophilicity and nucleophilicity, which was demonstrated in the reversible activation of alcohols and amines. The electronic structure of the resulting complexes was investigated through various spectroscopic and computational methods.

If you are interested in 89-01-0, you can contact me at any time and look forward to more communication. Name: Pyrazine-2,3-dicarboxylic acid.