Category: Pyrazines

π-Electron structure of some nitrogen heterocycles: azanaphthalenes, azaanthracenes and azaphenanthrenes was written by Birss, F. W.;Das Gupta, N. K.. And the article was included in Indian Journal of Chemistry in 1979.Computed Properties of C7H5N3 This article mentions the following:

The resonance energies of azanaphthalenes, azaanthracenes and azaphenanthrenes are predicted by means of empirical relation. The results are in good agreement with the Dewar resonance energy for the mols. studied. The effect of the N at different centers on the ground state properties was also discussed. Ionization potential, electron affinity and π-dipole moment were predicted and compared with exptl. ones where available. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Computed Properties of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Degradation products from amiloride hydrochloride was written by Goerlitzer, Klaus;Huth, Silke;Goessnitzer, Edith;Wendelin, Winfried. And the article was included in Scientia Pharmaceutica in 2004.Reference of 1458-01-1 This article mentions the following:

The degradation of amiloride hydrochloride (I) in acetate buffer pH 4.6 (reflux) was studied. The following products were obtained; amiloride acetate, 3-chloropyrazin-2,6-diamine, and 5-allophanoyl-3-chloropyrazin-2,6-diamine. The heating of I in DMF led to the formation of 2,7-diamino-6-chloro-4(3H)pteridinone. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Reference of 1458-01-1).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 1458-01-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Fourier-transform infrared and Raman spectra, vibrational assignment and density functional theory calculations of 1,4,5-triazanaphthalene was written by Krishnakumar, V.;Ramasamy, R.. And the article was included in Journal of Raman Spectroscopy in 2009.Computed Properties of C7H5N3 This article mentions the following:

The Fourier-transform IR (FT-IR) (4000-50 cm^-1) and Raman spectra (3500-100 cm^-1) of 1,4,5-triazanaphthalene in polycrystalline state were measured. Comparison between the spectra by 2 techniques, a series of d. functional theory (DFT) calculations and the spectral behavior upon deuteration were used for the assignment of the vibrational spectra of the title compound The calculated vibrational wavenumbers by the B3LYP d. functionals are generally consistent with the observed spectra. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Computed Properties of C7H5N3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Computed Properties of C7H5N3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Proton NMR spectra and structures of some bicyclic compounds oriented in nematic phases was written by Diehl, P.;Zimmermann, H.. And the article was included in Organic Magnetic Resonance in 1976.Product Details of 322-46-3 This article mentions the following:

The PMR spectra of 1,4,5-triazanaphthalene, benzothiazole, and quinoline, oriented in nematic liquid crystalline phases, were analyzed and the parameters used to determine interproton distance ratios. The symmetry of the benzene ring was violated when compared to the nonhetero analogs. In the experiment, the researchers used many compounds, for example, Pyrido[2,3-b]pyrazine (cas: 322-46-3Product Details of 322-46-3).

Pyrido[2,3-b]pyrazine (cas: 322-46-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Product Details of 322-46-3

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines was written by Venkat Ragavan, R.;Vijayakumar, V.;Rajesh, K.;Palakshi Reddy, B.;Karthikeyan, S.;Suchetha Kumari, N.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: pyrazines This article mentions the following:

A series of β-keto esters were synthesized from heteroaryl esters and Et acetate using LiHMDS as base at -50 to -30 °C. Increases in yields of cross-condensed products were observed and the percentage of self-condensed product was reduced drastically by applying the suitable base (LiHMDS), solvent, and a min. amount of Et acetate. All these β-keto esters were characterized using ¹H NMR, ¹³C NMR and mass spectral data. A plausible mechanism is also depicted to prove the formation of trans-esterified products. All the synthesized compounds were tested for their cytotoxicity towards various cancer cell lines and also tested for their antimicrobial activity towards various bacterial and fungal strains and some of them were found to have promising activity. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Category: pyrazines).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazine-based skeletons were incorporated into agents targeting a range of ailments. Many derivatives were synthesized and evaluated as potential cancer treatments.Category: pyrazines

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides was written by Cragoe, Edward J. Jr.;Woltersdorf, Otto W. Jr.;Bicking, John B.;Kwong, Sara F.;Jones, James Holden. And the article was included in Journal of Medicinal Chemistry in 1967.Computed Properties of C6H7ClN4O2 This article mentions the following:

The synthesis of a series of N-amidino-3-amino-5-substituted-6-halopyrazinecarboxamides (I) is described In rats and dogs, these compounds cause diuresis and saluresis while K excretion is unaffected or repressed Compounds with a variety of 5 substituents including hydroxy, alkoxy, mercapto, alkylmercapto, amino, and substitute amino were prepared The latter 2 tupes embrace compounds with the highest activity. Several routes for the synthesis of Me 3-amino-5,6-dichloropyrazinoate, a key intermediate, are presented. 23 references. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Computed Properties of C6H7ClN4O2).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging.Computed Properties of C6H7ClN4O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Protective effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine on vascular endothelial cells injured by hydrogen peroxide was written by Li, Chaowu;Liu, Xinyong;Zhang, Rui;Xu, Wenfang;Li, Zhong;Wang, Defeng. And the article was included in Shandong Daxue Xuebao, Yixueban in 2003.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:

The protective effects of 2-hydroxymethyl-3,5,6-trimethylpyrazine (HTMP) on human umbilical vein endothelial cells (HUVECs) injured by H₂O₂ were studied. HUVECs viability was assessed by Me thiazolyl tetrazolium assay and tetramethylpyrazine (TMP) was used as a controlled drug. HTMP (0.1-1.5 mM) highly stimulated the proliferation of normal HUVECs, and protected the injured HUVECs against suppression induced by H₂O₂, which had more potency than the pos. drug TMP. The exptl. data suggested that HTMP exerted protective action on injured HUVECs and had a great significance for repairing the injured endothelium in treatment of cardiovascular diseases. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

New amiloride analog as hapten to raise anti-amiloride antibodies was written by Kleyman, Thomas R.;Rajagopalan, Raghavan;Cragoe, Edward J. Jr.;Erlanger, Bernard F.;Al-Awqati, Qais. And the article was included in American Journal of Physiology in 1986.Name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate This article mentions the following:

A new amiloride analog amiloride-caproic acid, was synthesized, coupled to albumin, and used as a hapten to raise anti-amiloride antibodies in rabbits. The antibodies were affinity purified with an amiloride affinity column and characterized. Binding studies using [³H]benzamil showed a dissociation constant of 0.8 nM. Amiloride and amiloride-caproate inhibited [³H]benzamil binding; ε-guanidinocaproic acid showed no inhibition. Anti-amiloride antibodies reversed the inhibition by amiloride of Na transport across the toad urinary bladder. Anti-amiloride antibodies and an amiloride affinity column should provide useful tools for the characterization of the epithelial Na channel. In the experiment, the researchers used many compounds, for example, Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1Name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate).

Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (cas: 1458-01-1) belongs to pyrazine derivatives. Pyrazine is an N-heterocyclic moiety, and it can be easily prepared from ethylenediamine and 1,2-diketone, α-hydroxyketone, α-methyl ketone. Pyrazines are chemical compounds (technically called “methoxypyrazines”) found in grape skin and stems that are responsible for many “green” flavors in wine. Levels of pyrazines are dependent on viticultural practices, climate, and grape variety.Name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Ligustrazine Derivatives. Part 8: Design, Synthesis, and Preliminary Biological Evaluation of Novel Ligustrazinyl Amides as Cardiovascular Agents was written by Li, Zhenyu;Yu, Fang;Cui, Lei;Chen, Wenmin;Wang, Shouxun;Zhan, Peng;Shen, Yuemao;Liu, Xinyong. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2014.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol This article mentions the following:

A series of novel Ligustrazinyl amides was designed, synthesized and evaluated for their protective effect on the injured vascular endothelial cells. The preliminary results demonstrated that some compounds possessed more potent activities than that of Ligustrazine in stimulating replication of the injured human umbilical vascular endothelial cells (HUVECs) that is damaged by hydrogen peroxide. Among the active compounds, compounds 8i, 8t and 8u exhibited the highest potency with low EC50 values of 0.037, 0.070 and 0.055 mM, resp. Structure-activity relationships were briefly discussed. In the experiment, the researchers used many compounds, for example, (3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol).

(3,5,6-Trimethylpyrazin-2-yl)methanol (cas: 75907-74-3) belongs to pyrazine derivatives. Pyrazines are volatile compounds that are used in the cosmetic, food, flavor, and fragrance industries. A large number of pyrazine derivatives are known for their antitumor, antibiotic, anticonvulsant, antituberculosis, and diuretic activities.Application In Synthesis of (3,5,6-Trimethylpyrazin-2-yl)methanol

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

High-Performance and Light-Emitting n-Type Organic Field-Effect Transistors Based on Dithienylbenzothiadiazole and Related Heterocycles was written by Kono, Takahiro;Kumaki, Daisuke;Nishida, Jun-ichi;Sakanoue, Tomo;Kakita, Motoyasu;Tada, Hirokazu;Tokito, Shizuo;Yamashita, Yoshiro. And the article was included in Chemistry of Materials in 2007.Computed Properties of C8H4Br2N2 This article mentions the following:

Authors developed new semiconductors composed of donor-acceptor compounds including electron accepting benzothiazole and related heterocycles. The FET devices based on them showed high n-type performance. Using the benzothiazole unit, the threshold voltage was reduced to 3 CM^-1. The devices showed n-type light emitting FET characteristics, where the emission intensity was strongly dependent on the gate voltage. In the experiment, the researchers used many compounds, for example, 5,8-Dibromoquinoxaline (cas: 148231-12-3Computed Properties of C8H4Br2N2).

5,8-Dibromoquinoxaline (cas: 148231-12-3) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. A number of pyrazine-based derivatives were used as dyes or fluorescent probes.Computed Properties of C8H4Br2N2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem