Category: 98-97-5

An article Heterogeneous copper-catalyzed C-S coupling via insertion of sulfur dioxide: A novel and regioselective approach for the synthesis of sulfur-containing compounds WOS:000474675100001 published article about ONE-POT SYNTHESIS; H FUNCTIONALIZATION; ACTIVATION; SULFONYLATION; C(SP(2))-H; SODIUM in [Han, Junfen; Wang, Kai; You, Guirong; Wang, Guodong; Sun, Jian; Duan, Guiyun; Xia, Chengcai] Shandong First Med Univ & Shandong Acad Med Sci, Coll Pharm, Tai An 271000, Shandong, Peoples R China in 2019, Cited 35. Category: Pyrazines. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

A novel and regioselective protocol for C-S coupling of naphthylamines via the insertion of sulfur dioxide was developed by employing a heterogeneous copper catalyst, providing desired products in moderate to good yields. This strategy gives a powerful tool for the efficient preparation of sulfur-containing compounds. Control experiments declared that a single-electron transfer mechanism (SET) is responsible for this C-S cross coupling reaction.

Category: Pyrazines. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Han, JF; Wang, K; You, GR; Wang, GD; Sun, J; Duan, GY; Xia, CC or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2019 CHEMMEDCHEM published article about CRYSTAL-STRUCTURE; 20S PROTEASOME; ALPHA; EXPRESSION; BORTEZOMIB; SUBSTRATE; DOCKING in [Stubba, Daniel; Bensinger, Dennis; Steinbacher, Janika; Proskurjakov, Lilia; Gomez, Alvaro Salcedo; Schmitz, Katja; Schmidt, Boris] Tech Univ Darmstadt, Clemens Schoepf Inst Organ Chem & Biochem, Alarich Weiss Str 4, D-64287 Darmstadt, Germany; [Schmidt, Uwe; Roth, Stefan] Tech Univ Darmstadt, Dept Comp Sci, Visual Inference Lab, Huchschulstr 10, D-64289 Darmstadt, Germany in 2019, Cited 42. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Safety of Pyrazine-2-carboxylic acid

The ubiquitin-proteasome system (UPS) is an established therapeutic target for approved drugs to treat selected hematologic malignancies. While drug discovery targeting the UPS focuses on irreversibly binding epoxyketones and slowly-reversibly binding boronates, optimization of novel covalent-reversibly binding warheads remains largely unattended. We previously reported alpha-ketoamides to be a promising reversible lead motif, yet the cytotoxic activity required further optimization. This work focuses on the lead optimization of phenoxy-substituted alpha-ketoamides combining the structure-activity relationships from the primed and the non-primed site of the proteasome beta 5 subunit. Our optimization strategy is accompanied by molecular modeling, suggesting occupation of P1 ‘ by a 3-phenoxy group to increase beta 5 inhibition and cytotoxic activity in leukemia cell lines. Key compounds were further profiled for time-dependent inhibition of cellular substrate conversion. Furthermore, the alpha-ketoamide lead structure 27 does not affect escape response behavior in Danio rerio embryos, in contrast to bortezomib, which suggests increased target specificity.

Safety of Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Stubba, D; Bensinger, D; Steinbacher, J; Proskurjakov, L; Gomez, AS; Schmidt, U; Roth, S; Schmitz, K; Schmidt, B or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, antimicrobial and chitinase inhibitory activities of 3-amidocoumarins published in 2020. Recommanded Product: Pyrazine-2-carboxylic acid, Reprint Addresses Katiyar, D (corresponding author), Banaras Hindu Univ, Dept Chem, MMV, Varanasi 221005, Uttar Pradesh, India.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

A series of 3-amidocoumarins has been synthesized and tested in vitro for their anitimicrobial and chitinase inhibitory activities. Among these, compounds 5k, 5l, 8b-8d, 8f and 8g exhibited good antibacterial activity with MIC values in the range of 6.25-25 mu g/mL against some of the tested strains while compounds 5l, 8b, 8c and 8f showed good activity against at least one or two fungal strains. Some of the assayed compounds 5d, 5k, 5l, 8b and 8c displayed significant chitinase inhibitory activity with IC50, values in the range of 3.74-5.6 mu M. Among them, 5l proved to be potent chitinase inhibitor with IC50 value of 3.74 mu M. To better understand the enzyme-inhibitor interactions molecular docking study of all the synthesized compounds was carried out on Aspergillus fumigatus chitinase 1W9U. The compound 5l showed high binding affinity with the receptor with binding energy value of -8.44 Kcal/mol. This study also provides structure activity relationship (SAR) of synthesized compounds.

Recommanded Product: Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Sharma, RK; Singh, V; Tiwari, N; Butcher, RJ; Katiyar, D or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article A metal-free picolinamide assisted electrochemical ortho-trifluoromethylation of arylamines WOS:000603489100001 published article about C-H BOND; PALLADIUM-CATALYZED TRIFLUOROMETHYLATION; FLUORINATION; ALKENES; FUNCTIONALIZATION; ARYL; ACTIVATION; EFFICIENT; AMINOTRIFLUOROMETHYLATION; PERFLUOROALKYLATION in [Wang, Kai; Zhang, Changjun; Xie, Yuanyuan] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China; [Hou, Jiahao; Wei, Tingting; Bai, Renren; Xie, Yuanyuan] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China in 2021, Cited 74. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Formula: C5H4N2O2

An eco-friendly and effective electrochemical process was developed for the ortho-trifluoromethylation of arylamines using CF3SO2Na as the trifluoromethyl source, affording the desired products in moderate to good yields with high regioselectivity under mild reaction conditions. Importantly, the requirement for both transition metals and oxidants utilized in previous methods were avoided. A radical mechanism was proposed on the basis of various control experiments. (C) 2020 Elsevier Ltd. All rights reserved.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Wang, K; Hou, JH; Wei, TT; Zhang, CJ; Bai, RR; Xie, YY or concate me.. Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: 98-97-5. Recently I am researching about ACID-DERIVATIVES; IN-VIVO, Saw an article supported by the Sapienza Funding. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Pandolfi, F; D’Acierno, F; Bortolami, M; De Vita, D; Gallo, F; De Meo, A; Di Santo, R; Costi, R; Simonetti, G; Scipione, L. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Candida albicans biofilm represents a major clinical problem due to its intrinsic tolerance to anti-fungal compounds and it has been highly related to infections in catheterized patients. Few compounds are described as able to inhibit biofilm formation or to interfere with preformed biofilm of C. albicans. Here we report the in vitro evaluation of anti-biofilm activity on C albicans ATCC 10231 of a series of new and already known amine and amide indole derivatives. Among the studied compounds, fifteen resulted active on C albicans ATCC 10231 biofilm, with BMIC50 <= 16 mu g/mL. Three of them (7, 23 and 33) showed a selectivity towards mature biofilm and the most active of them was the compound 23 (BMIC50 = 4 mu g/mL). On the other hands, two different compounds (21 and 22) were selective towards biofilm formation with BMIC50 values of 8 mu g/mL Otherwise, compounds 16 and 17 resulted active on biofilm formation, with BMIC50 of 8 mu g/mL and 2 mu g/mL respectively, and on mature biofilm with BMIC50 of 2 mu g/mL. These two last compounds also showed an interesting activity towards the planktonic cells of C albicans. A selection of the more active compounds was also evaluated on different C albicans strains (PMC1042, PMC1083 and ATCC 10261), showing a comparable or higher anti-biofilm activity, especially on mature biofilm. In vivo toxicity studies using the Galleria mellonella larvae, were finally carried out on more active indole derivatives, showing that they are poorly toxic even at the highest concentrations tested (500-1000 mu g/mL). (C) 2019 Elsevier Masson SAS. All rights reserved. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Pandolfi, F; D'Acierno, F; Bortolami, M; De Vita, D; Gallo, F; De Meo, A; Di Santo, R; Costi, R; Simonetti, G; Scipione, L or concate me.. Recommanded Product: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Hassan, NW; Saudi, MN; Abdel-Ghany, YS; Ismail, A; Elzahhar, PA; Sriram, D; Nassra, R; Abdel-Aziz, MM; El-Hawash, SA in [Hassan, Nayera W.; Saudi, Manal N.; Abdel-Ghany, Yasser S.; Ismail, Azza; Elzahhar, Perihan A.; El-Hawash, Soad A.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt; [Sriram, Dharmarajan] Birla Inst Technol & Sci Pilani, Med Chem & Drug Discovery Res Lab, Pharm Grp, Hyderabad Campus, Jawahar Nagar 500078, Telangana, India; [Nassra, Rasha] Alexandria Univ, Fac Med, Dept Med Biochem, Alexandria, Egypt; [Abdel-Aziz, Marwa M.] Al Azhar Univ, Reg Ctr Mycol & Biotechnol, Cairo 11759, Egypt published Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies in 2020, Cited 84. Recommanded Product: Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moieties. Thirty-one compounds were screened in vitro for their activity against Mycobacterium tuberculosis H37Rv strain using MABA assay. The results revealed that six compounds (8a, 8b, 8c, 8d, 14b and 18) displayed significant activity against Mtb with MIC values <= 6.25 mu g/ml versus 6.25 mu g/ml for pyrazinamide. The most active compounds were then assessed for their in vitro cytotoxicity against PBMC normal cell line using MTT assay and showed SI > 200. Several in silico studies have been carried out for target fishing of the novel compounds such as shape-based similarity, pharmacophore mapping and inverse docking. Based on this multi-step target fishing study, we suggest that pantothenate synthetase could be the possible target responsible for the action of these compounds. The most active compounds were then successfully docked into the active site of pantothenate synthetase enzyme with favorable binding interactions. In addition, in silico prediction of physicochemical, ADMET and drug-like properties were also determined indicating that compounds 8b, 8c and 8d are promising candidates for the development of new anti-TB agents with enhanced activity and better safety profile.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Hassan, NW; Saudi, MN; Abdel-Ghany, YS; Ismail, A; Elzahhar, PA; Sriram, D; Nassra, R; Abdel-Aziz, MM; El-Hawash, SA or concate me.. Recommanded Product: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about CROSS-COUPLING REACTIONS; CARBOXYLIC-ACIDS; QUINOLINE; SITE; DERIVATIVES; CARBONYLATION; COMPLEXES; RECEPTOR, Saw an article supported by the Education Department of Henan Province [20 A210023]; Henan Agricultural University [30500567, 30500701]; Key Science and the Technology Program of Science and Technology Department of Henan Province [152102210058, 122102210129]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Hu, JY; Ye, XF; Hao, S; Zhao, QR; Zhao, MQ; Wei, YW; Wu, ZY; Wang, N; Ji, XM. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Formula: C5H4N2O2

A highly efficient and simple procedure for the synthesis quinoline-3-carboxamides and their analogues via amidation reaction of quinoline-3-carboxylic acids with tetraalkylthiuram disulfides has been developed. The reaction proceeds efficiently under simple reaction conditions and features the generality of broad scope of substrates with good yields. This protocol provides a convenient procedure for the synthesis of various aza-heteroaromatic carboxamides, which is of pharmaceutical interest.

Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Hu, JY; Ye, XF; Hao, S; Zhao, QR; Zhao, MQ; Wei, YW; Wu, ZY; Wang, N; Ji, XM or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Discovery ofN-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B WOS:000555606100001 published article about PARKINSONS-DISEASE; DERIVATIVES; SAFINAMIDE; TARGETS; OPTIMIZATION; SEMBRAGILINE; PHARMACOLOGY; MODELS; POTENT in [Elkamhawy, Ahmed; Lee, Kyeong; Pae, Ae Nim; Park, Ki Duk] Dongguk Univ Seoul, Coll Pharm, Goyang 10326, South Korea; [Elkamhawy, Ahmed] Mansoura Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Mansoura, Egypt; [Paik, Sora; Roh, Eun Joo] Korea Inst Sci & Technol KIST, Chem Kin Res Ctr, Seoul 02792, South Korea; [Kim, Hyeon Jeong; Park, Jong-Hyun; Londhe, Ashwini M.] Korea Inst Sci & Technol KIST, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul, South Korea; [Kim, Hyeon Jeong] Yonsei Univ, Dept Biotechnol, Seoul, South Korea; [Londhe, Ashwini M.; Pae, Ae Nim; Park, Ki Duk; Roh, Eun Joo] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul, South Korea; [Park, Ki Duk] Kyung Hee Univ, KHU KIST Dept Converging Sci & Technol, Seoul, South Korea in 2020, Cited 52. Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Herein, two new series ofN-substituted indole-based analogues were rationally designed, synthesizedviamicrowave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hitsVIandVII, compounds4band4eexhibited higher inhibitory activities over MAO-B with IC(50)values of 1.65 and 0.78 mu M, respectively. When compared to the modest selectivity index of rasagiline (II, a well-known MAO-B inhibitor, SI > 50), both4band4ealso showed better selectivity indices (SI > 60 and 120, respectively). A further kinetic evaluation of the most potent derivative (4e) displayed a competitive mode of inhibition (inhibition constant (K-i)/MAO-B = 94.52 nM). Reasonable explanations of the elicited biological activities were presentedviaSAR study and molecular docking simulation. Accordingly, the remarkable MAO-B inhibitory activity of4e(N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.

Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Elkamhawy, A; Paik, S; Kim, HJ; Park, JH; Londhe, AM; Lee, K; Pae, AN; Park, KD; Roh, EJ or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: Pyrazine-2-carboxylic acid. In 2020 CRYST GROWTH DES published article about HALIDE ION SYNTHON; CRYSTAL-STRUCTURES; INTERMOLECULAR INTERACTIONS; HYDROGEN-BONDS; MOLECULES; HIERARCHY; CROSSOVER; LIGANDS; METALS; BR in [Khavasi, Hamid Reza; Gholami, Akram; Hosseini, Mahdieh; Nikpoor, Leyla] Shahid Beheshti Univ, Dept Inorgan Chem & Catalysis, Tehran 1983963113, Iran; [Eskandari, Kiamars] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran in 2020, Cited 45. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A family of 10 compounds, each containing a MX2-pyrazine carboxylate complex anion and a protonated halo- (X’-) amino pyridine cation (MX2 = ZnCl2, ZnBr2, ZnI2, HgBr2, and HgI2; X’ = Cl, Br, I), are presented; a suitable system for pursuing C-X’center dot center dot center dot X-M halogen bonding (XB). The influence of halogen manipulation, metal ion and coordination variation on the nature and strength of C-X’center dot center dot center dot X-M interactions was discussed in terms of geometrical parameters, binding energies and charge density analysis with emphasis on the Laplacian of the electron density, del(2)rho. Interplay of XBs with other noncovalent interactions, mainly N-H center dot center dot center dot XM and N-py-H+center dot center dot center dot O- bonds, in supramolecular assemblies, were also investigated. The C-X’center dot center dot center dot X-M and N-H center dot center dot center dot X-M bonds have rationally been modified in strength upon changing the halogens involved, leading to systematic variations in the crystal packing.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Khavasi, HR; Gholami, A; Hosseini, M; Nikpoor, L; Eskandari, K or concate me.. Recommanded Product: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2021 EUR J ORG CHEM published article about ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; POSTCONDENSATION MODIFICATIONS; BUILDING-BLOCKS; SOLID-STATE; ISOCYANIDE; HEXAMETHYLENETETRAMINE; CHEMISTRY; AMMONIA; MECHANISM in [Rosalba, Thaissa Pasquali F.; Kas, Samia Sayegh A.; Sampaio, Ana Beatriz S.; Salvador, Carlos Eduardo M.; Andrade, Carlos Kleber Z.] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet LaQMOS, Campus Univ, BR-70904970 Brasilia, DF, Brazil in 2021, Cited 98. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Safety of Pyrazine-2-carboxylic acid

Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Rosalba, TPF; Kas, SSA; Sampaio, ABS; Salvador, CEM; Andrade, CKZ or concate me.. Safety of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem