Category: 98-97-5

In 2020 MOLECULES published article about MYCOBACTERIUM; DRUG; RESISTANCE; DELAMANID; DISCOVERY; MECHANISMS; INHIBITORS; ASSAY; Q203; BCG in [Brown, Alistair K.; Aljohani, Ahmed K. B.; Alsalem, Fatimah M. A.; Lu, Yucheng; Sellars, Jonathan D.] Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England; [Broadhead, Joseph L.] Arcinova, Taylor Dr, Alnwick NE66 2DH, England; [Gill, Jason H.] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England; [Gill, Jason H.; Sellars, Jonathan D.] Fac Med Sci, Sch Pharm, King George VI Bldg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England in 2020, Cited 34. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. SDS of cas: 98-97-5

Discovery and development of new therapeutic options for the treatment of Mycobacterium tuberculosis (Mtb) infection, particularly drug-resistant strains, are urgently required to tackle the global burden of this disease. Herein, we reported the synthesis of a novel series of N-substituted amino acid hydrazides, utilising a scaffold hopping approach within a library of anti-tubercular agents. Efficacy and selectivity were evaluated against three strains of Mtb (wild-type, isoniazid-resistant and rifampicin-resistant), and cytotoxicity against macrophages in vitro. The antibacterial activity and therapeutic index of these molecules were significantly affected by modifications with the N-substituents. Introduction of a 3,5-dinitroaryl moiety demonstrated enhanced antibacterial activity against all three strains of Mtb. In contrast, the inclusion of an imidazo [1,2-a]pyridine-3-carboxy moiety resulted in enhanced activity towards isoniazid mono-resistant Mtb relative to wild-type Mtb. Consequently, this scaffold hopping approach showed significant promise for exemplification of novel molecules with specific activity profiles against drug-resistant tuberculosis.

Welcome to talk about 98-97-5, If you have any questions, you can contact Brown, AK; Aljohani, AKB; Alsalem, FMA; Broadhead, JL; Gill, JH; Lu, YC; Sellars, JD or send Email.. SDS of cas: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

COA of Formula: C5H4N2O2. In 2019 J HETEROCYCLIC CHEM published article about ONE-POT SYNTHESIS; 2-SUBSTITUTED BENZOTHIAZOLES; OXIDATIVE CYCLIZATION; CATALYST; EFFICIENT; 2-ARYLBENZOXAZOLES; BASES in [Kashid, Bharat B.; Ghanwat, Anil A.; Dongare, Balasaheb B.] Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, MS, India; [Khedkar, Vijay M.] Shri Vile Parle Kelavani Mandals Inst Pharm, Dept Pharmaceut Chem, Dhule 424001, MS, India; [Shaikh, Mubarak H.; Deshpande, Prathmesh P.; Wakchaure, Yogesh B.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, MS, India in 2019, Cited 52. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A series of novel 2-substituted benzimidazole and benzoxazole derivatives as a potential antimicrobial and antioxidant agent were synthesized via coupling of N-methyl-o-phenylenediamine or 2-amino-phenol with aromatic aldehyde and acid in the presence of polyphosphoric acid as an efficient catalyst as well as solvent by conventional method in short reaction times with excellent yield. The newly synthesized benzimidazole and benzoxazole derivatives were evaluated for antimicrobial and antioxidant activity and exhibited excellent to good activities compared to the standard drugs. Furthermore, the theoretical predictions based on molecular docking against microbial DNA gyrase could provide an insight into the plausible mechanism of action and establish a link between the observed antimicrobial activity and the binding affinity shedding light on specific thermodynamic (bonded and nonbonded) interactions governing the activity. Furthermore, the synthesized compounds were analyzed for absorption, distribution, metabolism, and excretion properties and exhibited potential properties to build up as good oral drug candidates.

COA of Formula: C5H4N2O2. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Pd(II)-catalyzed, Picolinamide-aided sp(2) gamma-C-H Functionalization of Phenylglycinol: Access to gamma-C-H Arylated, Alkylated and Halogenated Phenylglycinol Scaffolds published in 2021. Formula: C5H4N2O2, Reprint Addresses Babu, SA (corresponding author), Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sect 81, Manauli Po 140306, Punjab, India.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

We report the Pd(II)-catalyzed picolinamide-aided ortho-C-H arylation-, alkylation-, and halogenation (sp(2) gamma-C-H functionalization) of phenylglycinol substrates. Phenylglycinols are remarkable building blocks and have found different applications in synthetic organic and medicinal chemistry. This work is a contribution towards the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)-catalyzed bidentate directing group picolinamide-aided C-H activation tactic.

Welcome to talk about 98-97-5, If you have any questions, you can contact Singh, P; Babu, SA; Aggarwal, Y; Patel, P or send Email.. Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Design, synthesis and anti-inflammatory evaluation of 3-amide benzoic acid derivatives as novel P2Y(14) receptor antagonists WOS:000493211900018 published article about MECHANISMS; IDENTIFICATION; INFLAMMASOME; CHEMOTAXIS in [Zhang, Zhenguo; Lu, Ran; Jiang, Cheng] China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China; [Zhang, Zhenguo; Lu, Ran; Li, Baiyang; Meng, Zibo; Jiang, Cheng] China Pharmaceut Univ, Dept Med Chem, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China; [Hao, Kun] China Pharmaceut Univ, State Key Lab Nat Med, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China; [Li, Hanwen; Liu, Chunxiao; Zhou, Mengze; Hu, Qinghua] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China in 2019, Cited 35. Recommanded Product: 98-97-5. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

The P2Y(14) receptor (P2Y(14)R) plays a key role in the modulation of inflammatory process, but very few classes of antagonists have been reported. A series of 3-amide benzoic acid derivatives were identified as novel and potent P2Y(14)R antagonists. The most potent antagonist, 16c, showed comparable activity (IC50 = 1.77 nM) to PPTN, the most potent P2Y(14)R antagonist reported. Compound 16c demonstrated dramatically improved aqueous solubility and excellent metabolic stability in rat and human microsomes. Investigation of the anti-inflammatory effect of 16c was performed in MSU treated THP-1 cells by flow cytometry, Western Blot and immunofluorescence labeling technology, which exhibited that 16c might be a promising candidate for further research. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 98-97-5, If you have any questions, you can contact Zhang, ZG; Hao, K; Li, HW; Lu, R; Liu, CX; Zhou, MZ; Li, BY; Meng, ZB; Hu, QH; Jiang, C or send Email.. Recommanded Product: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Andrade, MA; Mestre, AS; Carvalho, AP; Pombeiro, AJL; Martins, LMDRS in [Andrade, Marta A.; Pombeiro, Armando J. L.; Martins, Luisa M. D. R. S.] Univ Lisbon, Ctr Quim Estrutural, IST, P-1049001 Lisbon, Portugal; [Mestre, Ana S.; Carvalho, Ana P.] Univ Lisbon, Fac Ciencias, Ctr Quim & Bioquim, P-1749016 Lisbon, Portugal; [Mestre, Ana S.; Carvalho, Ana P.] Univ Lisbon, Fac Ciencias, Ctr Quim Estrutural, P-1749016 Lisbon, Portugal published The role of nanoporous carbon materials in catalytic cyclohexane oxidation in 2020, Cited 58. Recommanded Product: 98-97-5. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

The C-scorpionate iron(II) complex [FeCl2(Tpm)] [Tpm = kappa(3)-HC(C3H3N2)(3)] was immobilized on three nanoporous carbon supports to produce active, selective and recyclable catalysts for the oxidation of cyclohexane. The influence of the porous carbon supports on the performance of the heterogenized [FeCl2(Tpm)] catalyst was investigated using materials with distinct porosity: microporous (GL50-ox, wet oxidized GL50 Norit sample, and S, sisal-derived activated carbon prepared by chemical activation), and mesoporous (CMK-3) materials. The heterogenized systems exhibited good activity and rather high selectivity to the formation of KA (ketone-alcohol) oil (cyclohexanol and cyclohexanone mixture) from microwave-assisted oxidation of cyclohexane, and allowed their easy recovery and reuse, at least for four consecutive cycles. The most important outcome of this work was the significant self-catalytic activity observed for the pristine carbon materials GL50-ox and CMK-3 towards cyclohexane oxidation under Microwave irradiation, in the absence of the iron complex.

Welcome to talk about 98-97-5, If you have any questions, you can contact Andrade, MA; Mestre, AS; Carvalho, AP; Pombeiro, AJL; Martins, LMDRS or send Email.. Recommanded Product: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment WOS:000577619900006 published article about CYSTEINE PROTEASE; TRYPANOSOMA-CRUZI; DRUG DISCOVERY; INTEGRATION; ISOFORMS; LIGANDS; IMPROVE in [de Albuquerque, Sergio; Duque, Carla; da Silva, Joao Santana] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil; [Cianni, Lorenzo; de Vita, Daniela; Leitao, Andrei; Montanari, Carlos A.; Ribeiro, Jean F. R.] Univ Sao Paulo, Inst Quim Sao Carlos, Grp Quim Med, Ave Trabalhador Sancarlense 400, BR-13566590 Sao Carlos, SP, Brazil; [Gomes, Ana S. M.; Gomes, Paula; Teixeira, Catia] Univ Porto, Dept Quim & Bioquim, LAQV REQUIMTE, Fac Ciencias, Porto, Portugal; [Laughton, Charles] Univ Nottingham, Sch Pharm, Nottingham, England; [Laughton, Charles] Univ Nottingham, Ctr Biomol Sci, Nottingham, England; [Montanari, Raphael] Univ Sao Paulo, Ctr Robot Sao Carlos, EESC ICMC, Sao Paulo, Brazil; [Ribeiro, Jean F. R.] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil in 2020, Cited 59. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Category: Pyrazines

Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations? This work describes the development of a random forests model for the prediction of the bioavailability of cruzain inhibitors that areTrypanosoma cruzikillers. Some common properties that characterize drug-likeness are poorly represented in many established cruzain inhibitors. This correlates with the evidence that many high-affinity cruzain inhibitors are not trypanocidal agents againstT. cruzi. On the other hand,T. cruzikillers that present typical drug-like characteristics are likely to show better trypanocidal action than those without such features. The random forests model was not outperformed by other machine learning methods (such as artificial neural networks and support vector machines), and it was validated with the synthesis of two new trypanocidal agents. Specifically, we report a new lead compound,Neq0565, which was tested onT. cruziTulahuen (beta-galactosidase) with a pEC(50)of 4.9. It is inactive in the host cell line showing a selectivity index (SI = EC50cyto/EC50T. cruzi) higher than 50.

Category: Pyrazines. Welcome to talk about 98-97-5, If you have any questions, you can contact de Albuquerque, S; Cianni, L; de Vita, D; Duque, C; Gomes, ASM; Gomes, P; Laughton, C; Leitao, A; Montanari, CA; Montanari, R; Ribeiro, JFR; da Silva, JS; Teixeira, C or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Safety of Pyrazine-2-carboxylic acid. Walczak, M; Chryplewicz, A; Olewinska, S; Psurski, M; Winiarski, L; Torzyk, K; Oleksyszyn, J; Sienczyk, M in [Walczak, Maciej; Chryplewicz, Agnieszka; Olewinska, Sandra; Winiarski, Lukasz; Torzyk, Karolina; Oleksyszyn, Jozef; Sienczyk, Marcin] Wroclaw Univ Sci & Technol, Dept Organ & Med Chem, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland; [Psurski, Mateusz] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Dept Expt Oncol, Weigla 12, PL-53114 Wroclaw, Poland published Phosphonic Analogs of Alanine as Acylpeptide Hydrolase Inhibitors in 2021, Cited 54. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Acylpeptide hydrolase is a serine protease, which, together with prolyl oligopeptidase, dipeptidyl peptidase IV and oligopeptidase B, belongs to the prolyl oligopeptidase family. Its primary function is associated with the removal of N-acetylated amino acid residues from proteins and peptides. Although the N-acylation occurs in 50-90 % of eukaryotic proteins, the precise functions of this modification remains unclear. Recent findings have indicated that acylpeptide hydrolase participates in various events including oxidized proteins degradation, amyloid beta-peptide cleavage, and response to DNA damage. Considering the protein degradation cycle cross-talk between acylpeptide hydrolase and proteasome, inhibition of the first enzyme resulted in down-regulation of the ubiquitin-proteasome system and induction of cancer cell apoptosis. Acylpeptide hydrolase has been proposed as an interesting target for the development of new potential anticancer agents. Here, we present the synthesis of simple derivatives of (1-aminoethyl)phosphonic acid diaryl esters, phosphonic analogs of alanine diversified at the N-terminus and ester rings, as inhibitors of acylpeptide hydrolase and discuss the ability of the title compounds to induce apoptosis of U937 and MV-4-11 tumor cell lines.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Safety of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about C-H; STEREOSPECIFIC SYNTHESIS; ELECTROPHILIC AMINATION; CATALYZED AMINATION; BONDS, Saw an article supported by the Robert A. Welch FoundationThe Welch Foundation [I-0011]; Dr. Ralph and Marian Falk Medical Research Trust Bank of America, N.A., Trustee; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01HL139793]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Munnuri, S; Anugu, RR; Falck, JR. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Name: Pyrazine-2-carboxylic acid

Cu(II)-mediated direct NH2 and NH alkyl aryl aminations and olefin aziridinations are described. These room temperature, one-pot, environmentally friendly procedures replace costly Rh-2 catalysts and, in some instances, display important differences with comparable Rh-2- and Fe-supported reactions.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Name: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about INDEPENDENT CHEMICAL-SHIFTS; THROUGH-SPACE INTERACTIONS; FACE-TO-FACE; HYDROGEN-BOND; CRYSTAL-STRUCTURE; CURRENT-DENSITY; SANDWICH; SUBSTITUENTS; COMPLEXES; ENERGIES, Saw an article supported by the Ferdowsi University of Mashhad, Research Council [3/33540]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Samie, A; Salimi, A; Garrison, JC. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Formula: C5H4N2O2

Based on the crystal engineering concept, four new esters containing alpha and beta-substituted naphthalene rings were designed, synthesized and fully characterized. The crystal structure analysis of the designed molecules revealed that the C-H-based interactions especially C-HMIDLINE HORIZONTAL ELLIPSIS pi have a significant role in the stabilization of crystal architectures. Regarding the molecular structure of naphthalene rings, one can find that bond lengths are divided into two groups (shorter and longer) so that relative localization is likely to occur in this system. Since pi-electron localization in aromatic rings has been previously introduced as responsible for stronger pi-stacking, this issue was investigated through C-HMIDLINE HORIZONTAL ELLIPSIS pi interaction in this study. Cambridge Structural Database (CSD) analysis was performed by exploration of suitable geometries for C-HMIDLINE HORIZONTAL ELLIPSIS pi(c) and C-HMIDLINE HORIZONTAL ELLIPSIS pi(e) in naphthalene and phenol systems (pi(c) and pi(e) are the centre and edge of the aromatic rings, respectively). The tendency factor (TF) of the C-H moiety toward ring bonds as a new CSD-based criterion was used to detect some of the resonance forms in aromatic rings. The results indicated that C-HMIDLINE HORIZONTAL ELLIPSIS pi(e) is a ubiquitous interaction which can be employed as an experimental probe for the detection of pi-localization in naphthalene rings. Systematic experimental studies, structural evidence and computational results on the title compounds confirmed the relative pi-electron localization, as well.

Welcome to talk about 98-97-5, If you have any questions, you can contact Samie, A; Salimi, A; Garrison, JC or send Email.. Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors published in 2019. Recommanded Product: Pyrazine-2-carboxylic acid, Reprint Addresses Lei, M (corresponding author), Nanjing Forestry Univ, Coll Sci, 159 Longpan Rd, Nanjing 210037, Jiangsu, Peoples R China.; Zhu, YQ (corresponding author), Nanjing Normal Univ, Coll Life Sci, 1 Wenyuan Rd, Nanjing 210046, Jiangsu, Peoples R China.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

A series of novel tetrapeptidyl epoxyketone inhibitors of 20S proteasome was designed and synthesized. To fully understand the SAR, various groups at R-1, R-2, R-3, R-4 and R-5 positions, including aromatic and aliphatic substituents were designed, synthesized and biologically assayed. Based on the enzymatic results, seven compounds were selected to evaluate their cellular activities and soluble compound 36 showed strong potency against human multiple myeloma (MM) cell lines. Microsomal stability results indicated that compound 36 was more stable in mice, rat and human microsomes than marketed carfilzomib. The in vivo activities of this compound were evaluated with the xenograft mice models of MM cell lines ARH77 and RPMI-8226 with luciferase expression and the T/C value of the two models were 49.5% and 37.6%, respectively. To evaluate the potential cardiovascular toxicity, inhibition of hERG ion channel in HEK293 cells by compound 36 and carfilzomib was carried out. The results indicated that 36 had no binding affinity for the hERG ion channel while carfilzomib could bind it with IC50, of 92.1 mu M.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem