Category: 98-97-5

In 2021 EUR J ORG CHEM published article about ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; POSTCONDENSATION MODIFICATIONS; BUILDING-BLOCKS; SOLID-STATE; ISOCYANIDE; HEXAMETHYLENETETRAMINE; CHEMISTRY; AMMONIA; MECHANISM in [Rosalba, Thaissa Pasquali F.; Kas, Samia Sayegh A.; Sampaio, Ana Beatriz S.; Salvador, Carlos Eduardo M.; Andrade, Carlos Kleber Z.] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet LaQMOS, Campus Univ, BR-70904970 Brasilia, DF, Brazil in 2021, Cited 98. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Name: Pyrazine-2-carboxylic acid

Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.

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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA in [Kashid, Bharat B.; Salunkhe, Pravin H.; Dongare, Balasaheb B.; Ghanwat, Anil A.] Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, India; [Salunkhe, Pravin H.] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [More, Kishor R.] Shandong Keyuan Pharmaceut Co Ltd, Keyuan St, Jinan, Shandong, Peoples R China; [Khedkar, Vijay M.] Vishwakarma Univ, Sch Pharm, Survey 2,3,4 Laxminagar, Pune 411048, Maharashtra, India published Synthesis of novel of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study in 2020, Cited 43. Category: Pyrazines. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

Category: Pyrazines. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Name: Pyrazine-2-carboxylic acid. Authors Swiderski, G; Kalinowska, M; Jablonska-Trypuc, A; Wolejko, E; Wydro, U; Lyszczek, R; Rusinek, I; Lewandowski, W in ELSEVIER published article about in [Swiderski, Grzegorz; Kalinowska, Monika; Jablonska-Trypuc, Agata; Wolejko, Elzbieta; Wydro, Urszula; Lewandowski, Wlodzimierz] Bialystok Tech Univ, Dept Chem Biol & Biotechnol, Wiejska 45E St, PL-15351 Bialystok, Poland; [Lyszczek, Renata; Rusinek, Iwona] UMCS, Dept Gen & Coordinat Chem, MC Sklodowska Sq 2, PL-20031 Lublin, Poland in 2021, Cited 50. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Diazinecarboxylic acids (pyridazine-3-carboxylic, pyridazine-4-carboxylic, pyrimidine-2-carboxylic, pyrimidine-4-carboxylic, pyrimidine-5-carboxylic and pyrazine-2-carboxylic acids) were characterized by means of spectroscopic (FT-Raman, FTIR, UV, (HNMR)-H-1, (CNMR)-C-13) and thermogravimetric analysis as well as antimicrobial and cytotoxic tests. The structures of diazinecarboxylic acids were calculated by the DFT method (B3LYP/6-311G(d, p). For the most stable conformers, the energy of HOMO and LUMO molecular orbitals, the geometric (HOMA, GEO, EN, I6) and magnetic (NICS) aromaticity indices, NBO electronic charge distribution, sEDA and pEDA indexes, Wiberg Bond Order, Wiberg Index and theoretical IR and NMR spectra have been calculated. The energies of protonating and deprotonating acids were also calculated. The effect of the nitrogen heteroatom position in the aromatic ring in relation to the position of the carboxyl group on the electronic charge distribution, thermal stability, antimicrobial and cytotoxicity activities of the examined acids was determined. Antimicrobial activity of tested acids against of Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosaand Candida albicanswas calculated based on MTT colorimetric assay (MCA). The cytotocic effect of diazynecarboxylic acids was examined in A375 melanoma cell line and DLD-1 cell line. A biplot analysis was performed in order to determine the correlations between selected parameters of the tested compounds and relative cell viability of E. coli, B. subtilis, P. aeruginosa, C. albicans, A375 and DLD-1 cell lines. Thermal behaviour of all investigated carboxylic acids was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC) techniques in flowing air atmosphere. All compounds are stable in room temperature. (C) 2021 Elsevier B.V. All rights reserved.

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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Pyrazinamide triggers degradation of its target aspartate decarboxylase WOS:000564272800001 published article about TUBERCULOSIS; RESISTANCE; MUTATIONS; PROTEASE; COMPLEX in [Gopal, Pooja; Sarathy, Jickky Palmae] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore; [Yee, Michelle; Dick, Thomas] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore; [Ragunathan, Priya; Shin, Joon; Bhushan, Shashi; Grueber, Gerhard] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore; [Zhu, Junhao; Akopian, Tatos; Kandror, Olga; Rubin, Eric J.] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA; [Lim, Teck Kwang; Lin, Qingsong] Natl Univ Singapore, Dept Biol Sci, Singapore, Singapore; [Gengenbacher, Martin; Dick, Thomas] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ 07110 USA; [Gengenbacher, Martin; Dick, Thomas] Seton Hall Univ, Dept Med Sci, Hackensack Meridian Med Sch, Nutley, NJ 07110 USA; [Gopal, Pooja] Merck Res Labs, MSD Translat Med Res Ctr, Singapore, Singapore in 2020, Cited 29. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Category: Pyrazines

Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to aspartate decarboxylase PanD. While most drugs act by inhibiting protein function upon target binding, we find here that pyrazinoic acid is only a weak enzyme inhibitor. We show that binding of pyrazinoic acid to PanD triggers degradation of the protein by the caseinolytic protease ClpC1-ClpP. Thus, the old tuberculosis drug pyrazinamide exerts anti-bacterial activity by acting as a target degrader, a mechanism of action that has recently emerged as a successful strategy in drug discovery across disease indications. Our findings provide the basis for the rational discovery of next generation PZA.

Category: Pyrazines. Welcome to talk about 98-97-5, If you have any questions, you can contact Gopal, P; Sarathy, JP; Yee, M; Ragunathan, P; Shin, J; Bhushan, S; Zhu, JH; Akopian, T; Kandror, O; Lim, TK; Gengenbacher, M; Lin, QS; Rubin, EJ; Gruber, G; Dick, T or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Calculation of the Isobaric Heat Capacities of the Liquid and Solid Phase of Organic Compounds at and around 298.15 K Based on Their True Molecular Volume published in 2019. Quality Control of Pyrazine-2-carboxylic acid, Reprint Addresses Naef, R (corresponding author), Univ Basel, Dept Chem, CH-4003 Basel, Switzerland.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their true volume. The molecules’ true volume in A(3) is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the true volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids. The standard deviations for Cp(sol,298) were calculated to 23.14 J/mol/K for the first, 21.62 J/mol/K for the second, and 19.75 J/mol/K for the last subset. A discussion of structural and intermolecular effects influencing the heat capacities as well as of some special classes, in particular hydrocarbons, ionic liquids, siloxanes and metallocenes, has been given. In addition, the present method has successfully been extended to enable the prediction of the temperature dependence of the solid and liquid heat capacities in the range between 250 and 350 K.

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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; ANTIBACTERIAL ACTIVITY; RAMAN-SPECTROSCOPY; CONTROLLED-RELEASE; HYBRID MATERIALS; GRAPHITE; DELIVERY; NANOMATERIALS; CYTOTOXICITY; DOXORUBICIN, Saw an article supported by the EU (ERDF)European Commission [INFRANANOCHEM19/01.03.2009]; Romanian Government [INFRANANOCHEM19/01.03.2009]. Product Details of 98-97-5. Published in ELSEVIER SCIENCE BV in AMSTERDAM ,Authors: Tudos, M; Anghel, EM; Culita, DC; Somacescu, S; Calderon-Moreno, J; Tecuceanu, V; Dumitrascu, FD; Dracea, O; Popa, M; Marutescu, L; Bleotu, C; Curutiu, C; Chifiriuc, MC. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

In this work, we present a simple, two-stage method for the preparation of new and efficient antimicrobial hybrid systems, based on isoniazid and pyrazine-2-carbohydrazide tuberculostatic agents covalently linked to graphene oxide. In the first step, the carboxyl groups of graphene oxide are activated by transforming them into the corresponding acid chloride groups, which, in the second step, will react with the amino groups of the two drugs. Pyrazine-2-carbohydrazide was obtained from pyrazinoic acid and hydrazine hydrate and was confirmed by nuclear magnetic resonance spectroscopy. The materials have been characterized by elemental analysis, infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy. Their antimicrobial activity was tested on mycobacterial (Mycobacterium terrae), as well as on Gram-negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), Gram-positive bacteria (Staphylococcus aureus ATCC 6538, Staphylococcus aureus ATCC 25923) and fungal (Candida albicans ATCC 10231), in planktonic and biofilm growth state. The biocompatibility of the tested compounds was assessed in vitro by live-dead fluorescence staining and flow cytometry. The results of this study have shown that the functionalization of graphene oxide with isoniazid and pyrazine-2-carbohydrazide both enhanced the anti-mycobacterial activity of the respective drugs and extended their antimicrobial spectrum towards other microbial strains, in planktonic and biofilm growth state, showing a promising potential for mitigating the impact of antimicrobial resistance and the deleterious effects of microbial biofilms. At the active tuberculostatic concentrations, the tested compounds exhibit very low cytotoxicity and do not interfere with the cellular cycle of Hep-2 cells. The flow cytometry and live/dead fluorescence staining proved that the tested compounds exhibit a microbicidal effect through induction of cellular lesions, consecutive to membrane depolarization.

Welcome to talk about 98-97-5, If you have any questions, you can contact Tudos, M; Anghel, EM; Culita, DC; Somacescu, S; Calderon-Moreno, J; Tecuceanu, V; Dumitrascu, FD; Dracea, O; Popa, M; Marutescu, L; Bleotu, C; Curutiu, C; Chifiriuc, MC or send Email.. Product Details of 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2020 RSC ADV published article about MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL EVALUATION; IN-VITRO; DOCKING; ANALOGS in [Srinivasarao, Singireddi; Nandikolla, Adinarayana; Suresh, Amaroju; Aggarwal, Himanshu; Sekhar, Kondapalli Venkata Gowri Chandra] Birla Inst Technol & Sci, Dept Chem, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Calster, Kevin Van; De Voogt, Linda; Cappoen, Davie] Univ Ghent, Fac Biosci Engn, Dept Green Chem & Technol, Coupure Links 653, B-9000 Ghent, Belgium; [Ghosh, Balaram] Birla Inst Technol & Sci, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Murugesan, Sankaranarayanan] Birla Inst Technol & Sci, Dept Pharm, Med Chem Res Lab, Pilani 333031, Rajasthan, India in 2020, Cited 34. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Computed Properties of C5H4N2O2

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among the tested compounds, five compounds (6a, 6e, 6h, 6j and 6k) from Series-I and one compound (7e) from Series-II exhibited significant activity against Mycobacterium tuberculosis H37Ra with 50% inhibitory concentrations (IC50) ranging from 1.35 to 2.18 mu M. To evaluate the efficacy of these compounds, we examined their IC90 values. Five of the most active compounds were found to be more active with IC(90)s ranging from 3.73 to 4.00 mu M and one compound (6e) showed an IC90 of 40.32 mu M. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.

Welcome to talk about 98-97-5, If you have any questions, you can contact Srinivasarao, S; Nandikolla, A; Suresh, A; Van Calster, K; De Voogt, L; Cappoen, D; Ghosh, B; Aggarwal, H; Murugesan, S; Sekhar, KVGC or send Email.. Computed Properties of C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Authors Mustazzolu, A; Piersimoni, C; Iacobino, A; Giannoni, F; Chirullo, B; Fattorini, L in PENSIERO SCIENTIFICO EDITORE published article about SUSCEPTIBILITY in [Mustazzolu, Alessandro] Ist Super Sanita, Serv Comunicaz Sci, Rome, Italy; [Piersimoni, Claudio] AOU Osped Riuniti Ancona, Lab Patol Clin, Lab Unico Reg Diagnost Micobatteri, Ancona, Italy; [Iacobino, Angelo; Giannoni, Federico; Fattorini, Lanfranco] Ist Super Sanita, Dipartimento Malattie Infett, Viale Regina Elena 299, I-00161 Rome, Italy; [Chirullo, Barbara] Ist Super Sanita, Dipartimento Sicurezza Alimentare Nutr & Sanita P, Rome, Italy in 2019, Cited 22. Category: Pyrazines. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Pyrazinamide (PZA) is a first-line key drug used in combination with other agents for the treatment of tuberculosis (TB). Phenotypic and molecular assays for testing susceptibility of Mycobacterium tuberculosis (Mtb) to PZA have been developed, with the assay in liquid medium at acidic pH in the Bactec MGIT 960 (M960) system being routinely used in the mycobacteriology laboratories. However, false resistance to PZA by this method was reported to occur by several investigators, mostly due to high Mtb inoculum, which may impair drug activity by increasing the pH of the medium. In this study, a revision of the literature on the issue of false resistance in the M960 PZA assay was performed. In the reports examined, all improvements of the M960 test proposed to decrease false resistant results were based on the use of reduced inoculum densities of Mtb cells, to be easily translated into laboratory practice.

Welcome to talk about 98-97-5, If you have any questions, you can contact Mustazzolu, A; Piersimoni, C; Iacobino, A; Giannoni, F; Chirullo, B; Fattorini, L or send Email.. Category: Pyrazines

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Exploration of relative pi-electron localization in naphthalene aromatic rings by C-HMIDLINE HORIZONTAL ELLIPSIS pi interactions: experimental evidence, computational criteria, and database analysis WOS:000493072200012 published article about INDEPENDENT CHEMICAL-SHIFTS; THROUGH-SPACE INTERACTIONS; FACE-TO-FACE; HYDROGEN-BOND; CRYSTAL-STRUCTURE; CURRENT-DENSITY; SANDWICH; SUBSTITUENTS; COMPLEXES; ENERGIES in [Samie, Ali; Salimi, Alireza] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Iran; [Garrison, Jered C.] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE USA in 2019, Cited 72. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Quality Control of Pyrazine-2-carboxylic acid

Based on the crystal engineering concept, four new esters containing alpha and beta-substituted naphthalene rings were designed, synthesized and fully characterized. The crystal structure analysis of the designed molecules revealed that the C-H-based interactions especially C-HMIDLINE HORIZONTAL ELLIPSIS pi have a significant role in the stabilization of crystal architectures. Regarding the molecular structure of naphthalene rings, one can find that bond lengths are divided into two groups (shorter and longer) so that relative localization is likely to occur in this system. Since pi-electron localization in aromatic rings has been previously introduced as responsible for stronger pi-stacking, this issue was investigated through C-HMIDLINE HORIZONTAL ELLIPSIS pi interaction in this study. Cambridge Structural Database (CSD) analysis was performed by exploration of suitable geometries for C-HMIDLINE HORIZONTAL ELLIPSIS pi(c) and C-HMIDLINE HORIZONTAL ELLIPSIS pi(e) in naphthalene and phenol systems (pi(c) and pi(e) are the centre and edge of the aromatic rings, respectively). The tendency factor (TF) of the C-H moiety toward ring bonds as a new CSD-based criterion was used to detect some of the resonance forms in aromatic rings. The results indicated that C-HMIDLINE HORIZONTAL ELLIPSIS pi(e) is a ubiquitous interaction which can be employed as an experimental probe for the detection of pi-localization in naphthalene rings. Systematic experimental studies, structural evidence and computational results on the title compounds confirmed the relative pi-electron localization, as well.

Quality Control of Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact Samie, A; Salimi, A; Garrison, JC or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Authors Guin, S; Dolui, P; Zhang, XL; Paul, S; Singh, VK; Pradhan, S; Chandrashekar, HB; Anjana, SS; Paton, RS; Maiti, D in WILEY-V C H VERLAG GMBH published article about in [Guin, Srimanta; Dolui, Pravas; Paul, Satyadip; Singh, Vikas Kumar; Pradhan, Sukumar; Chandrashekar, Hediyala B.; Anjana, S. S.; Maiti, Debabrata] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India; [Zhang, Xinglong; Paton, Robert S.] Univ Oxford, Chem Res Lab, Dept Chem, Mansfield Rd, Oxford OX1 3TA, England in 2019, Cited 72. COA of Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Directed C-H functionalization has been realized as a complementary tool to the traditional approaches for a straightforward access of non-proteinogenic amino acids; albeit such a process is restricted mostly up to the gamma-position. In the present work, we demonstrate the diverse (hetero) arylation of amino acids and analogous aliphatic amines selectively at the remote delta-position by tuning the reactivity controlled by ligands. An organopalladium delta-C(sp(3))-H activated intermediate has been isolated and crystallographically characterized. Mechanistic investigations carried out experimentally in conjunction with computational studies shed light on the difference in the mechanistic picture depending on the substrate structure.

COA of Formula: C5H4N2O2. Welcome to talk about 98-97-5, If you have any questions, you can contact Guin, S; Dolui, P; Zhang, XL; Paul, S; Singh, VK; Pradhan, S; Chandrashekar, HB; Anjana, SS; Paton, RS; Maiti, D or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem