Category: 98-97-5

Walczak, M; Chryplewicz, A; Olewinska, S; Psurski, M; Winiarski, L; Torzyk, K; Oleksyszyn, J; Sienczyk, M in [Walczak, Maciej; Chryplewicz, Agnieszka; Olewinska, Sandra; Winiarski, Lukasz; Torzyk, Karolina; Oleksyszyn, Jozef; Sienczyk, Marcin] Wroclaw Univ Sci & Technol, Dept Organ & Med Chem, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland; [Psurski, Mateusz] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Dept Expt Oncol, Weigla 12, PL-53114 Wroclaw, Poland published Phosphonic Analogs of Alanine as Acylpeptide Hydrolase Inhibitors in 2021, Cited 54. Quality Control of Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Acylpeptide hydrolase is a serine protease, which, together with prolyl oligopeptidase, dipeptidyl peptidase IV and oligopeptidase B, belongs to the prolyl oligopeptidase family. Its primary function is associated with the removal of N-acetylated amino acid residues from proteins and peptides. Although the N-acylation occurs in 50-90 % of eukaryotic proteins, the precise functions of this modification remains unclear. Recent findings have indicated that acylpeptide hydrolase participates in various events including oxidized proteins degradation, amyloid beta-peptide cleavage, and response to DNA damage. Considering the protein degradation cycle cross-talk between acylpeptide hydrolase and proteasome, inhibition of the first enzyme resulted in down-regulation of the ubiquitin-proteasome system and induction of cancer cell apoptosis. Acylpeptide hydrolase has been proposed as an interesting target for the development of new potential anticancer agents. Here, we present the synthesis of simple derivatives of (1-aminoethyl)phosphonic acid diaryl esters, phosphonic analogs of alanine diversified at the N-terminus and ester rings, as inhibitors of acylpeptide hydrolase and discuss the ability of the title compounds to induce apoptosis of U937 and MV-4-11 tumor cell lines.

Welcome to talk about 98-97-5, If you have any questions, you can contact Walczak, M; Chryplewicz, A; Olewinska, S; Psurski, M; Winiarski, L; Torzyk, K; Oleksyszyn, J; Sienczyk, M or send Email.. Quality Control of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Authors Samie, A; Salimi, A; Garrison, JC in ROYAL SOC CHEMISTRY published article about INDEPENDENT CHEMICAL-SHIFTS; THROUGH-SPACE INTERACTIONS; FACE-TO-FACE; HYDROGEN-BOND; CRYSTAL-STRUCTURE; CURRENT-DENSITY; SANDWICH; SUBSTITUENTS; COMPLEXES; ENERGIES in [Samie, Ali; Salimi, Alireza] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Iran; [Garrison, Jered C.] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE USA in 2019, Cited 72. COA of Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Based on the crystal engineering concept, four new esters containing alpha and beta-substituted naphthalene rings were designed, synthesized and fully characterized. The crystal structure analysis of the designed molecules revealed that the C-H-based interactions especially C-HMIDLINE HORIZONTAL ELLIPSIS pi have a significant role in the stabilization of crystal architectures. Regarding the molecular structure of naphthalene rings, one can find that bond lengths are divided into two groups (shorter and longer) so that relative localization is likely to occur in this system. Since pi-electron localization in aromatic rings has been previously introduced as responsible for stronger pi-stacking, this issue was investigated through C-HMIDLINE HORIZONTAL ELLIPSIS pi interaction in this study. Cambridge Structural Database (CSD) analysis was performed by exploration of suitable geometries for C-HMIDLINE HORIZONTAL ELLIPSIS pi(c) and C-HMIDLINE HORIZONTAL ELLIPSIS pi(e) in naphthalene and phenol systems (pi(c) and pi(e) are the centre and edge of the aromatic rings, respectively). The tendency factor (TF) of the C-H moiety toward ring bonds as a new CSD-based criterion was used to detect some of the resonance forms in aromatic rings. The results indicated that C-HMIDLINE HORIZONTAL ELLIPSIS pi(e) is a ubiquitous interaction which can be employed as an experimental probe for the detection of pi-localization in naphthalene rings. Systematic experimental studies, structural evidence and computational results on the title compounds confirmed the relative pi-electron localization, as well.

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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Role of pi-conjugation on the coordination behaviour, substitution kinetics, DNA/BSA interactions, and in vitro cytotoxicity of carboxamide palladium(II) complexes WOS:000653084400001 published article about COLON-CANCER CELLS; PLATINUM(II) COMPLEXES; MOLECULAR DOCKING; PT(II) COMPLEXES; BENIGN SYNTHESIS; DNA CLEAVAGE; CT-DNA; LIGANDS; BINDING; ANTICANCER in [Omondi, Reinner O.; Ojwach, Stephen O.] Univ KwaZulu Natal, Sch Chem & Phys, Private Bag X01, ZA-3209 Pietermaritzburg, South Africa; [Sibuyi, Nicole R. S.; Fadaka, Adewale O.; Meyer, Mervin] Univ Western Cape, Dept Biotechnol, Bag X17, ZA-7535 Cape Town, South Africa; [Jaganyi, Deogratius] Mt Kenya Univ, Sch Pure & Appl Sci, POB 342-01000, Thika, Kenya; [Jaganyi, Deogratius] Durban Univ Technol, Fac Sci Appl, Dept Chem, POB 1334, ZA-4000 Durban, South Africa in 2021, Cited 70. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Application In Synthesis of Pyrazine-2-carboxylic acid

Treatments of N-(pyridin-2-ylmethyl)pyrazine-2-carboxamide (L-1), N-(quinolin-8-yl)pyrazine-2-carboxamide (L-2), N-(quinolin-8-yl)picolinamide (L-3) and N-(quinolin-8-yl)quinoline-2-carboxamide (L-4) with [PdCl2(NCMe)](2) afforded the corresponding Pd(ii) complexes, [Pd(L-1)Cl] (PdL1); [Pd(L-2)Cl] (PdL2); [Pd(L-3)Cl] (PdL3); and [Pd(L-4)Cl] (PdL4) in moderate yields. Structural characterisation of the compounds was achieved by NMR and FT-IR spectroscopies, elemental analyses and single crystal X-ray crystallography. The solid-state structures of complexes PdL2-PdL4 established the presence of one tridentate carboxamide and Cl ligands around the Pd(ii) coordination sphere, to give distorted square planar complexes. Electrochemical investigations of PdL1-PdL4 showed irreversible one-electron oxidation reactions. Kinetics reactivity of the complexes towards bio-molecules, thiourea (Tu), l-methionine (L-Met) and guanosine 5 ‘-diphosphate disodium salt (5 ‘-GMP) decreased in the order: PdL1 > PdL2 > PdL3 > PdL4, in tandem with the density functional theory (DFT) data. The complexes bind favourably to calf thymus (CT-DNA), and bovine serum albumin (BSA), and the order of their interactions agrees with the substitution kinetics trends. The in vitro cytotoxic activities of PdL1-PdL4 were examined in cancer cell lines A549, PC-3, HT-29, Caco-2, and HeLa, and a normal cell line, KMST-6. Overall, PdL1 and PdL3 displayed potent cytotoxic effects on A549, PC-3 HT-29 and Caco-2 comparable to cisplatin. All the investigated complexes exhibited lower toxicity on normal cells than cisplatin.

Application In Synthesis of Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Dumpala, RMR; Srivastava, A; Rawat, N in [Dumpala, Rama Mohana Rao; Srivastava, Ashutosh; Rawat, Neetika] Bhabha Atom Res Ctr, Radiochem Div, Mumbai 400085, Maharashtra, India published Experimental and theoretical approach to probe the aquatic speciation of transuranic (neptunyl) ion in presence of two omnipresent organic moieties in 2021, Cited 53. Name: Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Pyrazines are omnipresent in nature and have their occurrence in plants, microbes, food supplies, marine arenas. The present studies aimed at aquatic speciation of the neptunyl ion (NpO2+) with two pyrazine compounds namely pyrazine monocarboxylic acid (PMC) and pyrazine dicarboxylic acid (PDC). Absorption spectrophotometry was used to probe the stability, speciation and spectral properties for the complexation process. NpOO2+ forms a more stable complex with PMC than PDC for 1:1 (ML), while for 1:2 (ML2) the opposite trend is observed. The extent of shift in lambda(max), which is also an indicator for the strength of complexation, reflected similar trends for the complexation process. Isothermal titration calorimetry was employed to determine the enthalpies of complex formation, which is found to be endothermic. The complexation process is entropy driven. Linear free energy correlations were established to retrieve the coordination modes of the complexes. The variation in peak potentials (the cyclic voltammograms) with change in pH and metal to ligand ratio were explored to understand redox speciation, electron transfer kinetics and Eh-pH characteristics for the interaction of NpOO2+ with pyrazine carboxylate ligands. Density functional theory calculations were employed to optimize the geometries and to calculate the bond distances and partial charges on key atoms of the optimized geometries. The theoretical calculations helped to reveal the contributions from two different configurations of the same geometry towards the optical absorption. The bond distances and partial charges estimated theoretically helped to understand the aqueous interactions at the molecular level. (C) 2021 Elsevier Ltd. All rights reserved.

Name: Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2020 BIOORG CHEM published article about ANTIFUNGAL; CONDENSATION; ALLOSAMIDIN; DERIVATIVES; RESISTANCE; COUMARINS; SCAFFOLD; ARGADIN; AGENTS in [Sharma, Rajesh Kumar; Tiwari, Neha; Katiyar, Diksha] Banaras Hindu Univ, Dept Chem, MMV, Varanasi 221005, Uttar Pradesh, India; [Singh, Vineeta] Inst Engn & Technol, Dept Biotechnol, Sitapur Rd, Lucknow 226021, Uttar Pradesh, India; [Butcher, R. J.] Howard Univ, Dept Chem, 525 Coll St NW, Washington, DC 20059 USA in 2020, Cited 45. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Name: Pyrazine-2-carboxylic acid

A series of 3-amidocoumarins has been synthesized and tested in vitro for their anitimicrobial and chitinase inhibitory activities. Among these, compounds 5k, 5l, 8b-8d, 8f and 8g exhibited good antibacterial activity with MIC values in the range of 6.25-25 mu g/mL against some of the tested strains while compounds 5l, 8b, 8c and 8f showed good activity against at least one or two fungal strains. Some of the assayed compounds 5d, 5k, 5l, 8b and 8c displayed significant chitinase inhibitory activity with IC50, values in the range of 3.74-5.6 mu M. Among them, 5l proved to be potent chitinase inhibitor with IC50 value of 3.74 mu M. To better understand the enzyme-inhibitor interactions molecular docking study of all the synthesized compounds was carried out on Aspergillus fumigatus chitinase 1W9U. The compound 5l showed high binding affinity with the receptor with binding energy value of -8.44 Kcal/mol. This study also provides structure activity relationship (SAR) of synthesized compounds.

Name: Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact Sharma, RK; Singh, V; Tiwari, N; Butcher, RJ; Katiyar, D or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; ANTIMYCOBACTERIAL EVALUATION; IN-VITRO; DOCKING; ANALOGS, Saw an article supported by the DBT, New DelhiDepartment of Biotechnology (DBT) India [BT/IN/Spain/39/SMl2017-18]; DST FIST, New DelhiDepartment of Science & Technology (India) [SR/FST/CSI-240/2012]; CSIRCouncil of Scientific & Industrial Research (CSIR) – India. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Srinivasarao, S; Nandikolla, A; Suresh, A; Van Calster, K; De Voogt, L; Cappoen, D; Ghosh, B; Aggarwal, H; Murugesan, S; Sekhar, KVGC. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Formula: C5H4N2O2

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among the tested compounds, five compounds (6a, 6e, 6h, 6j and 6k) from Series-I and one compound (7e) from Series-II exhibited significant activity against Mycobacterium tuberculosis H37Ra with 50% inhibitory concentrations (IC50) ranging from 1.35 to 2.18 mu M. To evaluate the efficacy of these compounds, we examined their IC90 values. Five of the most active compounds were found to be more active with IC(90)s ranging from 3.73 to 4.00 mu M and one compound (6e) showed an IC90 of 40.32 mu M. Moreover, single crystals were developed for 6d, 6f and 6n. In addition, most active compounds were evaluated for their cytotoxicity on HEK-293 (human embryonic kidney) cells. Our results indicate that the compounds are nontoxic to human cells. The molecular interactions of the derivatised conjugates in docking studies reveal their suitability for further development.

Formula: C5H4N2O2. Welcome to talk about 98-97-5, If you have any questions, you can contact Srinivasarao, S; Nandikolla, A; Suresh, A; Van Calster, K; De Voogt, L; Cappoen, D; Ghosh, B; Aggarwal, H; Murugesan, S; Sekhar, KVGC or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Sun, QG; Li, XJ; Perez, LM; Shi, WL; Zhang, Y; Sacchettini, JC in [Sun, Qingan; Li, Xiaojun; Sacchettini, James C.] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA; [Perez, Lisa M.] Texas A&M Univ, Lab Mol Simulat, College Stn, TX USA; [Shi, Wanliang; Zhang, Ying] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA published The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD in 2020, Cited 30. COA of Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis. Pyrazinamide is a pro-drug that is converted into pyrazinoic acid (POA) by pyrazinamidase, however, the exact target of the drug has been difficult to determine. Here we show the enzyme PanD binds POA in its active site in a manner consistent with competitive inhibition. The active site is not directly accessible to the inhibitor, suggesting the protein must undergo a conformational change to bind the inhibitor. This is consistent with the slow binding kinetics we determined for POA. Drug-resistant mutations cluster near loops that lay on top of the active site. These resistant mutants show reduced affinity and residence time of POA consistent with a model where resistance occurs by destabilizing the closed conformation of the active site. The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the target of PZA and determine the POA bound Mtb PanD crystal structure.

COA of Formula: C5H4N2O2. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about RENAL-FUNCTION; METABOLITES; CLEARANCE; RIFAMPIN, Saw an article supported by the South African Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC); University of the Western Cape. Published in SPRINGER FRANCE in PARIS ,Authors: Mugabo, P; Mulubwa, M. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Formula: C5H4N2O2

Background and ObjectivesPyrazinamide, a drug used in the regimen for the treatment of drug-sensitive tuberculosis, is also used for the treatment of multidrug-resistant tuberculosis (MDR-TB). We aimed to describe the population pharmacokinetics of pyrazinamide and its major metabolite, pyrazinoic acid, in patients with MDR-TB and characterise the effects of demographic variables.MethodsThis was a non-randomised clinical study involving 51 adult patients admitted for the intensive phase of MDR-TB treatment. Blood samples were collected at pre-dose and at 0.5, 1, 1.5, 2, 3, 4, 8, 16 and 24h after drug administration. Plasma concentrations of pyrazinamide and pyrazinoic acid were analysed using a validated LC-MS/MS method. Nonlinear mixed-effects modelling using Monolix 2018R1 software was employed to estimate population pharmacokinetic parameters.ResultsA one-compartment pharmacokinetic model with transit compartment absorption process and first-order elimination best described the pyrazinamide and pyrazinoic acid concentration-time data. The estimated population pharmacokinetic parameters were 0.7h, 3.38h(-1), 57.1l, 4.37L/h and 10.5L/h for mean transit time, absorption rate constant, apparent distribution volume for pyrazinamide, and apparent clearance for pyrazinamide and pyrazinoic acid (CLm/F), respectively. These parameters were not affected by patient age, HIV status or sex. The parameter variability in CLm/F was the highest (83.5%), while the rest of the parameters ranged from 16.2 to 58%.ConclusionsThe developed population pharmacokinetic model adequately described the disposition of pyrazinamide and pyrazinoic acid and can be useful for dose determination of pyrazinamide in patients with MDR-TB.

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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model WOS:000456349300014 published article about PSEUDOMONAS-AERUGINOSA; ACID in [Leiris, Simon; Coelho, Alicia; Castandet, Jerome; Bayet, Maelle; Lozano, Clarisse; Bougnon, Juliette; Bousquet, Justine; Everett, Martin; Lemonnier, Marc; Sprynski, Nicolas; Zalacain, Magdalena; Davies, David T.] Antabio SAS, 436 Rue Pierre & Marie Curie, F-31670 Labege, France; [Zalacain, Magdalena] Zala Drug Discovery Consulting LLC, W Chester, PA 19380 USA; [Pallin, Thomas David; Cramp, Michael C.; Jennings, Neil; Raphy, Gilles; Jones, Mark W.] 8 9 Spire Green Ctr, Charles River Labs, Harlow CM19 5TR, Essex, England; [Pattipati, Ramesh; Shankar, Battu; Sivasubrahmanyam, Relangi; Soodhagani, Ashok K.; Juventhala, Ramakrishna R.; Pottabathini, Narender; Pothukanuri, Srinivasu] GVK Biosci Private Ltd, Plot 28 A,IDA Nacharam, Hyderabad 500076, India; [Benvenuti, Manuela; Pozzi, Cecilia; Mangani, Stefano] Univ Siena, Dept Biotechnol Chem & Pharm, 2 Via Aldo Moro, I-53100 Siena, Italy; [De Luca, Filomena; Cerboni, Giulia; Docquier, Jean-Denis] Univ Siena, Dept Med Biotechnol, 16 Viale Bracci, I-53100 Siena, Italy; [Pottabathini, Narender] Laurus Labs Ltd, Plot DS1,IKP Knowledge Pk, Hyderabad 500078, Telangana, India in 2019, Cited 24. Computed Properties of C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-beta-lactamase (MBL) and serine-beta-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new beta-lactamase inhibitors to be used in conjunction with carbapenems and other beta-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-beta-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Azizian, H; Esmailnejad, A; Vavsari, VF; Mahernia, S; Amanlou, M; Balalaie, S in [Azizian, Homa] Iran Univ Med Sci, Sch Pharm, Dept Med Chem, Int Campus, Tehran, Iran; [Esmailnejad, Atefeh; Fathi Vavsari, Vaezeh; Balalaie, Saeed] KN Toosi Univ Technol, Peptide Chem Res Ctr, POB 15875-4416, Tehran, Iran; [Mahernia, Shabnam; Amanlou, Massoud] Univ Tehran Med Sci, TIPS, Drug Design & Dev Res Ctr, Tehran, Iran; [Balalaie, Saeed] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran published Pantoprazole Derivatives: Synthesis, Urease Inhibition Assay and In Silico Molecular Modeling Studies in 2020, Cited 42. Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A number of pantoprazole derivatives were synthesized and screened for their urease inhibitory properties. Some of them showed potent inhibitions against jack bean urease. All compounds showed varying degree of IC50 in the range of 25.85 to 181 mu Mol as compared to standard acetohydroxamic acid (AHA) (100 +/- 2.02 mu Mol). Derivatives bearing 5-aryl-1,3,4-oxadiazole ring substitutions (aryl= pyrazyl, pyridyl and phenyl) were found to be more potent inhibitors than AHA and pantoprazole. The most promising compound, 2-((3,4-dimethoxypyridin-2-yl)methylthio)-5-(pyrazin-2-yl)-1,3,4-oxadiazole 12, with IC50 value of 25.85 +/- 1.21 showed remarkable urease inhibition activity. In silico molecular modeling investigation performed to rationalize the possible binding interaction and ADME properties of compounds over the active site of urease enzyme. The induced fit docking study showed that compound 12 interacted with conserved residues His593 and Arg609 located at the mouth of the urease active site flap and are essential for enzyme catalytic activity. These target compounds could be further studied as a lead skeleton for discovery of novel urease inhibitors.

Formula: C5H4N2O2. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem