Category: 98-97-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 98-97-5, name is Pyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C5H4N2O2

General procedure: A catalytic amount of concentrated H2SO4 wasadded to a solution of carboxylic acids 16(a-j) (1.0 mmol)in 50 mL of methanol, and the mixture was refluxed for 6 h. It was allowed to cool. The saturated solution ofNaHCO3 was added to the reaction mixture, and it wasextracted with EtOAc (2 X 50 mL). The combined organiclayer was dried Na2SO4 and concentrated to obtain puremethyl esters 17(a-j).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Murty; Penthala, Raju; Polepalli, Sowjanya; Jain; Medicinal Chemistry Research; vol. 25; 4; (2016); p. 627 – 643;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 98-97-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-97-5, name is Pyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

Figure ID shows a table of products produced by using a catalytic redox system comprising 20 mol % organocatalyst lg and 10 mol % CuI2(NMI)4 in MeCN under dry air (4 A molecular sieves) at 50 C, a variety of amides were constructed from 1.0 equiv of a carboxylic acid, 1.2 equiv of an amine, and 1.5 equiv of triethyl phosphite. For workup and isolation, the MeCN was filtered, and the solids were washed with CH2C12. The solvents were evaporated, and the products were obtained by Si02 chromatography. The entries span 1 and 2 amines, aliphatic and aromatic amines, amino acids and amino alcohols/phenols. The method is compatible with oxidation-prone substrates such as alkenes, boron derivatives, and furans and indoles as well as with electron-deficient heterocycles and benzene derivatives, and it works well for amines with a significant range of piH), chiral amine partners, chiral acid partners, and others. No racemization of stereocenters was observed for those substrates studied. The synthesis of peptide 3a shown in was carried out on a 5 g scale and delivered the product in 91% yield after 24 h at 50 C.

The chemical industry reduces the impact on the environment during synthesis Pyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; EMORY UNIVERSITY; LIEBESKIND, Lanny Steven; GANGIREDDY, Pavan Kumar Reddy; AKONDI, Sri Rama Murthy; (97 pag.)WO2017/70157; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 98-97-5,Some common heterocyclic compound, 98-97-5, name is Pyrazine-2-carboxylic acid, molecular formula is C5H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pyrazine-2-carb aldehyde A round bottom flask was charged with pyrazine carboxylic acid (17.7 g, 140 mMol), methanol (200 mL) and conc. sulphuric acid (2 mL) and the mixture was stirred at reflux for 4 hrs then left to stand overnight. The next day the mixture was refluxed for 2 more hours. The solvent was then evaporated in vacuo, the residue was diluted with dichloromethane and neutralised with 20% sodium bicarbonate solution. The dichloromethane phase was dried over MgS04 and evaporated to give the crude product as an off-white solid. Purification by column chromatography (silica gel, dichloromethane) gave pyrazinecarboxylic acid methyl ester 13.5 g as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2-carboxylic acid, its application will become more common.

Reference:
Patent; F2G LTD; WO2005/92304; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

98-97-5, name is Pyrazine-2-carboxylic acid, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C5H4N2O2

General procedure: The N-hydroxysuccinimide esters of pyrazinecarboxylic acidand (S)-(+)-ibuprofen were prepared by dissolving the starting acid(0.200 g, 1.0 equiv) in dry tetrahydrofuran and setting to stir at 0C. N-Hydroxysuccinimide (1.0 equiv) was added followed by N,N0-dicyclohexylcarbodiimide (1.0 equiv). The mixture was warmedto room temperature and stirred for 24 h. The N,N?-dicyclohexylureawas removed by filtration and the filtrate was concentratedto afford a solid that was purified by column chromatography..

The synthetic route of 98-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bakas, Nicole A.; Schultz, Chad R.; Yco, Lisette P.; Roberts, Christopher C.; Chang, Chia-en A.; Bachmann, Andre S.; Pirrung, Michael C.; Bioorganic and Medicinal Chemistry; vol. 26; 2; (2018); p. 401 – 412;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 98-97-5,Some common heterocyclic compound, 98-97-5, name is Pyrazine-2-carboxylic acid, molecular formula is C5H4N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pyrazinecarboxylic acid (2.72 g, 21.9 mmol) was added to a solution of L- cyclohexylglycine methyl ester (4.13 g, 19.9 mmol) in CH2CI2 (100 ml) at room temperature under N2, forming a white suspension. Triethylamine (6.33 ml, 4.62 g, 45.8 mmol) was added, followed by benzotriazol-l-yloxy-tris-(dimethylamino)- phosphonium hexafluorophosphate (BOP; 9.69 g, 21.9 mmol), which turned the reaction mixture from purple to an orange solution. After two days of stirring at room temperature the reaction mixture was washed two times with 50 ml saturated Na2CC>3, followed by the washing of the aqueous layers with CH2CI2 (2 chi 50 ml). The organic layers were collected and dried with MgSC , followed by concentration in vacuo. Purification by silica gel flash chromatography (c-Hex:EtOAc = 2: 1 with 0.5% triethylamine) afforded 9 (5.28 g, 19.03 mmol, 96%) as a yellow oil that solidified upon standing to give a white solid.[a f = +42.5 (c= 1.13, CHC13); *H NMR (250.13 MHz, CDCI3) delta = 9.39 (d, J= 1.25 Hz, 1H), 8.76 (d, J = 2.5 Hz, 1H), 8.57 (t, J = 1.5 Hz, 1H), 8.25 (d, J = 8.8 Hz, 1H), 4.74 (dd, J= 5.5, 9.3 Hz, 1H), 3.78 (s, 3H), 1.96 (m, 1H), 1.77 (m, 5H), 1.24 (m, 5H); 13C NMR (62.90 MHz, CDCI3): delta= 172.0 (C), 162.8 (C), 147.4 (CH), 144.5 (CH), 144.1 (C), 142.7(CH), 57.0 (CH), 52.3 (CH3), 41.2 (CH), 29.7 (CH2), 28.4 (CH2), 26.0 (CH2); IR (neat): v^cm ) = 3374 (m), 2920 (s), 2845 (w), 1740 (s), 1665 (s); HRMS (ESI, 4500 V): m/z calcd. for Ci4Hi9N303Na+ ([M + Na]+) 300.1319, found 300.1319.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2-carboxylic acid, its application will become more common.

Reference:
Patent; VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG; RUIJTER, Eelco; ORRU, Romano; ZNABET, Anass; POLAK, Marloes; TURNER, Nicholas; WO2011/103932; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 98-97-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-97-5, name is Pyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(a) A mixture of 68.2 g (0.55 moles) 2-pyrazine carboxylic acid and methylene chloride (about 200 ml) containing a catalytic amount of pyridine was warmed (to about 30 C.). To that mixture, 78.5 g (0.66 mole) thionyl chloride was added dropwise. The reaction mixture was refluxed for 24 hours. The methylene chloride was removed under reduced pressure and heat to give the 2-pyrazine carboxylic acid chloride which was used in step (b) without further isolation.

The synthetic route of Pyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 98-97-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 98-97-5, name is Pyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A catalytic amount of concentrated H2SO4 wasadded to a solution of carboxylic acids 16(a-j) (1.0 mmol)in 50 mL of methanol, and the mixture was refluxed for 6 h. It was allowed to cool. The saturated solution ofNaHCO3 was added to the reaction mixture, and it wasextracted with EtOAc (2 X 50 mL). The combined organiclayer was dried Na2SO4 and concentrated to obtain puremethyl esters 17(a-j).

The chemical industry reduces the impact on the environment during synthesis Pyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference:
Article; Murty; Penthala, Raju; Polepalli, Sowjanya; Jain; Medicinal Chemistry Research; vol. 25; 4; (2016); p. 627 – 643;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-97-5, name is Pyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 98-97-5

(1) Pyrazine-2-carboxylic acid is fully dissolved in anhydrous methanol,Then add an appropriate amount of concentrated sulfuric acid and heat to reflux for 5 h.After the reaction is cooled, adjust the pH to neutral with saturated NaHCO3,Extract with dichloromethane and keep the dichloromethane layer,The solvent was removed by rotary evaporation to obtain an oily pyrazine-2-carboxylic acid methyl ester;After dissolving it in anhydrous methanol, hydrazine hydrate was added dropwise, and after heating under reflux for 21 h,Cool to room temperature, remove methanol by rotary evaporation to obtain pyrazine-2-hydrazide as a red solid product;The ratio of the amount of pyrazine-2-carboxylic acid methyl ester to the amount of hydrazine hydrate is 1: 2.

The synthetic route of 98-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tianjin Medical University; Xu Jingyuan; Wang Zhigang; Xie Chengzhi; (13 pag.)CN110372681; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 98-97-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98-97-5 name is Pyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Pyrazine-2-carb aldehyde A round bottom flask was charged with pyrazine carboxylic acid (17.7 g, 140 mMol), methanol (200 mL) and conc. sulphuric acid (2 mL) and the mixture was stirred at reflux for 4 hrs then left to stand overnight. The next day the mixture was refluxed for 2 more hours. The solvent was then evaporated in vacuo, the residue was diluted with dichloromethane and neutralised with 20% sodium bicarbonate solution. The dichloromethane phase was dried over MgS04 and evaporated to give the crude product as an off-white solid. Purification by column chromatography (silica gel, dichloromethane) gave pyrazinecarboxylic acid methyl ester 13.5 g as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 98-97-5, name is Pyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98-97-5, COA of Formula: C5H4N2O2

A solution of pyrazine-2-carboxylic acid (Aldrich, 12.41 g, 0.1 mol) in MeOH (Aldrich, anhydrous, 100 mL) was stirred with H2SO4 (Aldrich, concentrated, 2 mL) at reflux for 6 hours. The reaction mixture was then concentrated and treated with saturated aqueous Na2CO3 solution (20 mL) till pH=8-9. The mixture was extracted with EtOAc (3*100 mL), and the combined extracts were washed with brine (2*20 mL) and dried over MgSO4. The drying agent was removed by filtration. The organic solution was concentrated and dried to give the title compound 1H NMR (300 MHz, CDCl3) delta 4.06 (s, 3H), 8.73 (dd, J=2.4, 1.6 Hz, 1H), 8.79 (d, J=2.4 Hz, 1H), 9.33 (d, J=1.6 Hz, 1H) ppm. MS (DCI/NH3) m/z 139 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.