Category: 98-97-5

An article Novel coumarin-isatin hybrids as potent antileishmanial agents: Synthesis, in silico and in vitro evaluations WOS:000647574400008 published article about LEISHMANIA; INFECTION; DOCKING in [Khatoon, Saira; Hameed, Shahid; Naseer, Muhammad Moazzam] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Aroosh, Aiman; Islam, Arshad; Kalsoom, Saima; Yasinzai, Masoom] Int Islamic Univ, Fac Basic & Appl Sci, Suleiman Bin Abdullah Aba Akhail Ctr Interdiscipl, Islamabad 44000, Pakistan; [Islam, Arshad] Govt Lady Reading Hosp Med Teaching Inst, Dept Pathol, Peshawar, KPK, Pakistan; [Ahmad, Faisal] Quaid I Azam Univ, Natl Ctr Bioinformat, Islamabad 45320, Pakistan; [Abbasi, Sumra Wajid] Natl Univ Med Sci, Dept Biol Sci, Rawalpindi, Pakistan in 2021, Cited 48. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Product Details of 98-97-5

Leishmaniasis being one of the six major tropical diseases that affects nearly 0.7-1.3 million people annually, has so far limited and high toxic therapeutic options. Herein, we report the synthesis, in silico, and in vitro evaluations of novel coumarin-incorporated isatin hydrazones (Spf-1 – Spf-10) as highly potent and safe antileishmanial agents. Molecular docking was initially carried out to decipher the binding confirmation of lead molecules towards the active cavity of the target protein (Leishmanolysin gp63) of Leishmania tropica. Among all the docked compounds, only Spf-6, Spf-8, and Spf-10 showed high binding affinities due to a pattern of strong conventional hydrogen bonds and hydrophobic pi-interactions. The molecular dynamics simulations showed the stable pattern of such bonding and structure-based confirmation with a time scale of 50 ns towards the top compound (Spf-10) and protein. These analyses affirmed the high stability of the system. Three out of ten compounds evaluated for their antileishmanial activity against Leishmania tropica promastigotes and amastigotes were found to be active at micromolar concentrations (IC50 range 0.1-4.13 mu mol/L), and most importantly, they were also found to be highly biocompatible when screened for their toxicity in human erythrocytes.

Product Details of 98-97-5. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Khatoon, S; Aroosh, A; Islam, A; Kalsoom, S; Ahmad, F; Hameed, S; Abbasi, SW; Yasinzai, M; Naseer, MM or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2019 EUR J ORG CHEM published article about PROTECTING GROUP; OLIGOSACCHARIDES; GLYCANS; TRI in [Lei, Jin-Cai; Ruan, Yu-Xiong; Luo, Sheng; Yang, Jin-Song] Sichuan Univ, West China Hosp, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug,Educ Minist, Chengdu 610041, Sichuan, Peoples R China; [Lei, Jin-Cai; Ruan, Yu-Xiong; Luo, Sheng; Yang, Jin-Song] Sichuan Univ, West China Hosp, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Sichuan, Peoples R China; [Lei, Jin-Cai; Ruan, Yu-Xiong; Luo, Sheng; Yang, Jin-Song] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China in 2019, Cited 47. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Application In Synthesis of Pyrazine-2-carboxylic acid

The tuning effect of C3-ester groups on the glycosylation stereochemistry of L-rhamnopyranose (L-Rha) ethyl thioglycoside donors is described. On one hand, the L-Rha thioglycoside donors carrying 3-O-arylcarbonyl or levulinoyl group undergo highly alpha-selective glycosylation to afford a wide variety of alpha-L-rhamnoside products in high chemical yields. On the other hand, the glycosylation of the 3-O-4-nitropicoloyl and 2-pyrazinecarbonyl group substituted L-Rha thioglycosides displays beta-stereoselectivity. Only or predominant beta anomeric products are obtained when these L-Rha donors couple with the primary or reactive secondary acceptors, while the beta-selectivity may decrease significantly when these donors react with less reactive secondary alcohols. The synthetic utility of the newly developed alpha- and beta-directing L-Rha donors 1h and 1e has been demonstrated by the efficient synthesis of a structurally unique trisaccharide 9, which is derived from the cell wall polysaccharide of Sphaerotilus natans.

Application In Synthesis of Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Lei, JC; Ruan, YX; Luo, S; Yang, JS or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

COA of Formula: C5H4N2O2. In 2019 ANTI-CANCER DRUG published article about INHIBITORS; DISCOVERY; POTENT; ANGIOGENESIS; SAR in [Huang, Yuanzheng; Zhang, Yang; Li, Jiaming; Ma, Xiaodong; Hu, Mengqi; Yang, Yu; Gao, Sufan] Anhui Acad Chinese Med, Sch Pharm, Dept Pharmaceut Chem, Hefei, Anhui, Peoples R China; [Li, Jiaming; Ma, Xiaodong] Anhui Acad Chinese Med, Dept Med Chem, Hefei, Anhui, Peoples R China in 2019, Cited 18. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A novel structural series of tetrahydroisoquinoline-based compounds that incorporate the diaryl urea moiety was designed, synthesized, and biologically evaluated as suppressors of VEFGR-2 signaling. As a consequence, compounds 9k and 9s exhibited comparable or superior cytotoxic activity to that of gefitinib against the tested three cell lines, including A549, MCF-7, and PC-3. Importantly, both of them downregulated the expression of VEGFR-2, and inhibited VEGFR-2 phosphorylation at the concentration of 0.5 or 1.0 mu mol/ l. Besides, they suppressed human umbilical vein endothelial cell tube formation at the concentration of 4.0 mu mol/ l. Considering their capability of down-regulating VEGFR-2 expression and inhibiting VEGFR-2 phosphorylation, 9k and 9s may serve as suppressors of angiogenesis for further investigation. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.

COA of Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Huang, YZ; Zhang, Y; Li, JM; Ma, XD; Hu, MQ; Yang, Y; Gao, SF or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Wang, YT; Wu, YS; Tang, GM in [Wang, Yong-Tao; Wu, Yu-Song; Tang, Gui-Mei] Qilu Univ Technol, Shandong Acad Sci, Dept Chem Engn, Jinan 250353, Shandong, Peoples R China published Controllable luminescent behaviors with pyrazine and benzimidazole groups: Syntheses, crystal structures and properties in 2019, Cited 103. Name: Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A set of new salts containing benzimidazole and pyrazine groups, namely, [HPZBI]X-+(-) nH(2)O (X = Cl (n = 1) (1), NO3 (n = 1) (2), ClO4 (n = 0) (3) and H2PO4 (n = 0) (4)) [PZBI = 2-(pyrazin-2-yl)-1H-benzimidazole], were obtained by the reaction of PZBI and a set of inorganic acid, respectively. The emission maxima can be found at 444, 472, 471, 432 and 443 nm for PZBI and its compounds 1-4 in the solid state at room temperature, respectively. Compared with the free PZBI, the emission maxima of compounds 1-4 are obviously blue/red-shifted for 1-4, indicating that the emission maxima are relative to the intermolecular packing distances. Their photoluminescent lifetime and quantum yield are 1.10 ns and 24.5% for 1, 0.99 ns and 26.4% for 2, 0.94 ns and 21.65% for 3, 2.86 ns and 20.57% for 4, respectively. Compounds 1-4 were structurally characterized by X-ray single crystal diffraction, FT-IR, and UV-Vis spectra. Single crystal X-ray diffraction reveals that pi center dot center dot center dot pi packing interactions and a set of hydrogen bonds can be observed. The shortest distances of pi center dot center dot center dot pi stacking interactions are 3.613, 3.534, 3.731 and 3.492 angstrom in compounds 1-4, respectively. Additionally, the thermal stabilities of compounds 1-4 were investigated in detail.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Wang, YT; Wu, YS; Tang, GM or concate me.. Name: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Pentacyanoferrate(II) complex of pyridine-4-and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities WOS:000555669500001 published article about MYCOBACTERIUM-TUBERCULOSIS; PRUSSIAN BLUE; NITROXYL; PYRAZINAMIDE; INSIGHTS; DRUG; ACTIVATION; MECHANISMS; RESISTANCE; NO in [Carvalho, Edinilton Muniz; Paulo, Tercio de Freitas; Saquet, Alix Sournia; Chauvin, Remi; Bernardes-Genisson, Vania] CNRS, Lab Chim Coordinat, LCC, UPR 8241, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France; [Carvalho, Edinilton Muniz; Paulo, Tercio de Freitas; Chauvin, Remi; Bernardes-Genisson, Vania] Univ Toulouse, Univ Paul Sabatier, UPS, 118 Route Narbonne, F-31062 Toulouse 9, France; [Carvalho, Edinilton Muniz; Paulo, Tercio de Freitas; Franca Lopes, Luiz Gonzaga; Silva Sousa, Eduardo Henrique] Univ Fed Ceara, Dept Quim Organ & Inorgan, Grp Bioinorgen, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil; [Abbadi, Bruno Lopes; Macchi, Fernanda Souza; Bizarro, Cristiano Valim] Pontificia Univ Catolica Rio Grande Do Sul PUCRS, Ctr Pesquisas Biol Mol & Func CPBMF, Porto Alegre, RS, Brazil; [Abbadi, Bruno Lopes; Macchi, Fernanda Souza; Bizarro, Cristiano Valim; Franca Lopes, Luiz Gonzaga; Silva Sousa, Eduardo Henrique] Inst Nacl Ciencia & Tecnol TB INCT TB, Porto Alegre, RS, Brazil; [Campos, Rafael de Morais; Abrantes Ferreira, Talles Luann; Falcao do Nascimento, Nilberto Robson] Univ Estadual Ceara, Lab Farmacol Cardiovasc & Renal, Campus Itaperi, BR-60714903 Fortaleza, Ceara, Brazil in 2020, Cited 40. COA of Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release active species upon enzymatic oxidative activation, is devised. This is exemplified by combining two anti-mycobacterial drugs: pyrazinamide (first line) and delamanid (third line) whose active metabolites are pyrazinoic acid (PyzCOOH) and likely nitroxyl (HNO (or NO.)), respectively. Aiming to generate those active species, a hybrid compound was envisaged by coordination of pyrazine-2-hydroxamic acid (PyzCONHOH) with a Na-3[Fe-II(CN)(5)] moiety. The corresponding pentacyanoferrate(II) complex Na-4[Fe-II(CN)(5)(PyzCONHO(-))] was synthesized and characterized by several spectroscopic techniques, cyclic voltammetry, and DFT calculations. Chemical oxidation of this complex with H(2)O(2)was shown to induce the release of the metabolite PyzCOOH, without the need of theMycobacterium tuberculosis(Mtb) pyrazinamidase enzyme (PncA). Control experiments show that both H2O2- and N-coordinated pyrazine Fe(II)species are required, ruling out a direct hydrolysis of the hydroxamic acid or an alternative oxidative route through chelation of a metal center by a hydroxamic group. The release of HNO was observed using EPR spectroscopy in the presence of a spin trapping agent. The devised iron metal complex of pyrazine-2-hydroxamic acid was found inactive against an actively growing/non-resistantMtbstrain; however, it showed a strong dose-dependent and reversible vasodilatory activity with mostly lesser toxic effects than the reference drug sodium nitroprussiate, unveiling thus a potential indication for acute or chronic cardiovascular pathology. This is a priori a further indirect evidence of HNO release from this metal complex, standing as a possible pharmacophore model for an alternative vasodilator drug.

COA of Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Carvalho, EM; Paulo, TD; Saquet, AS; Abbadi, BL; Macchi, FS; Bizarro, CV; Campos, RD; Ferreira, TLA; do Nascimento, NRF; Lopes, LGF; Chauvin, R; Sousa, EHS; Bernardes-Genisson, V or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Molecular design aided by random forests and synthesis of potent trypanocidal agents as cruzain inhibitors for Chagas disease treatment WOS:000577619900006 published article about CYSTEINE PROTEASE; TRYPANOSOMA-CRUZI; DRUG DISCOVERY; INTEGRATION; ISOFORMS; LIGANDS; IMPROVE in [de Albuquerque, Sergio; Duque, Carla; da Silva, Joao Santana] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo, Brazil; [Cianni, Lorenzo; de Vita, Daniela; Leitao, Andrei; Montanari, Carlos A.; Ribeiro, Jean F. R.] Univ Sao Paulo, Inst Quim Sao Carlos, Grp Quim Med, Ave Trabalhador Sancarlense 400, BR-13566590 Sao Carlos, SP, Brazil; [Gomes, Ana S. M.; Gomes, Paula; Teixeira, Catia] Univ Porto, Dept Quim & Bioquim, LAQV REQUIMTE, Fac Ciencias, Porto, Portugal; [Laughton, Charles] Univ Nottingham, Sch Pharm, Nottingham, England; [Laughton, Charles] Univ Nottingham, Ctr Biomol Sci, Nottingham, England; [Montanari, Raphael] Univ Sao Paulo, Ctr Robot Sao Carlos, EESC ICMC, Sao Paulo, Brazil; [Ribeiro, Jean F. R.] Univ Fed Goias, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil in 2020, Cited 59. COA of Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations? This work describes the development of a random forests model for the prediction of the bioavailability of cruzain inhibitors that areTrypanosoma cruzikillers. Some common properties that characterize drug-likeness are poorly represented in many established cruzain inhibitors. This correlates with the evidence that many high-affinity cruzain inhibitors are not trypanocidal agents againstT. cruzi. On the other hand,T. cruzikillers that present typical drug-like characteristics are likely to show better trypanocidal action than those without such features. The random forests model was not outperformed by other machine learning methods (such as artificial neural networks and support vector machines), and it was validated with the synthesis of two new trypanocidal agents. Specifically, we report a new lead compound,Neq0565, which was tested onT. cruziTulahuen (beta-galactosidase) with a pEC(50)of 4.9. It is inactive in the host cell line showing a selectivity index (SI = EC50cyto/EC50T. cruzi) higher than 50.

COA of Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact de Albuquerque, S; Cianni, L; de Vita, D; Duque, C; Gomes, ASM; Gomes, P; Laughton, C; Leitao, A; Montanari, CA; Montanari, R; Ribeiro, JFR; da Silva, JS; Teixeira, C or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)picolinamide as a new inhibitor of mitochondrial complex III: Synthesis, biological evaluation and computational simulations WOS:000546629300011 published article about CYTOCHROME BC(1) COMPLEX; IRON-SULFUR PROTEIN; BC1 COMPLEX; DISCOVERY; SITE; FUNGICIDE; AMETOCTRADIN; RESISTANCE; MECHANISM; BINDING in [Cheng, Hua; Yang, Lu; Liu, Hong-Fu; Zhang, Rui] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, Xiangyang 441053, Peoples R China; [Chen, Cheng] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China; [Wu, Yuan; Jiang, Wen] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China in 2020, Cited 47. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Quality Control of Pyrazine-2-carboxylic acid

Mitochondrial complex III is one of the most promising targets for a number of pharmaceuticals and fungicides. Due to the wide-spread use of complex III-inhibiting fungicides, a considerable increase of resistance has occurred worldwide. Therefore, inhibitors with novel scaffolds and potent activity against complex III are still in great demand. In this article, a new series of amide compounds bearing the diaryl ether scaffold were designed and prepared, followed by the biological evaluation. Gratifyingly, several compounds demonstrated potent activity against succinate-cytochrome c reductase (SCR, a mixture of mitochondrial complex II and complex III), with compound 3w possessing the best inhibitory activity (IC50 = 0.91 +/- 0.09 mu mol/L). Additional studies verified that 3w was a new inhibitor of complex III. Moreover, computational simulations elucidated that 3w should bind to the Q(o) site of complex III. We believe this work will be valuable for the preparation and discovery of more complex III inhibitors.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Cheng, H; Yang, L; Liu, HF; Zhang, R; Chen, C; Wu, Y; Jiang, W or concate me.. Quality Control of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about CORROSION-INHIBITORS; HYDROCHLORIC-ACID; CARBON-STEEL; BENZIMIDAZOLE DERIVATIVES; SCHIFF-BASES; PART II; ADSORPTION; BEHAVIOR; IODIDE; THIOSEMICARBAZONE, Saw an article supported by the Cukurova University Scientific Research Projects Coordination UnitCukurova University [FDK-2017-9860]; Mardin Artuklu UniversityMardin Artuklu University. Name: Pyrazine-2-carboxylic acid. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Kelesoglu, A; Sigircik, G; Yildiz, R; Dehri, I. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Pyrazinecarboxylic acid (PCA) was examined as a potential corrosion inhibitor for mild steel (MS) in 0.5 M HCl environment. The methods of electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR), as well potentiodynamic (PD) polarization were utilized. Furthermore, atomic force microscopy (AFM) and quantum chemical calculations were utilized. PD polarization curves demonstrated that PCA exhibited mixed inhibitor behavior. Scanning electron microscopy (SEM) offered the creation of an adsorptive layer on the surface of MS which prevented the steel against corrosive specimens. Furthermore, density functional theory (DFT) presented good agreement with electrochemical experimental results. The adsorption equilibrium constant (k(ads)) value was calculated to be 3.704 x 10(4) M-1 which was related to a high proportion of inhibitor on the surface. In the presence of 1.0 mM PCA, inhibition efficiency was determined as 95.2% from EIS results.

Name: Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Kelesoglu, A; Sigircik, G; Yildiz, R; Dehri, I or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2020 J BIOL INORG CHEM published article about MYCOBACTERIUM-TUBERCULOSIS; PRUSSIAN BLUE; NITROXYL; PYRAZINAMIDE; INSIGHTS; DRUG; ACTIVATION; MECHANISMS; RESISTANCE; NO in [Carvalho, Edinilton Muniz; Paulo, Tercio de Freitas; Saquet, Alix Sournia; Chauvin, Remi; Bernardes-Genisson, Vania] CNRS, Lab Chim Coordinat, LCC, UPR 8241, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France; [Carvalho, Edinilton Muniz; Paulo, Tercio de Freitas; Chauvin, Remi; Bernardes-Genisson, Vania] Univ Toulouse, Univ Paul Sabatier, UPS, 118 Route Narbonne, F-31062 Toulouse 9, France; [Carvalho, Edinilton Muniz; Paulo, Tercio de Freitas; Franca Lopes, Luiz Gonzaga; Silva Sousa, Eduardo Henrique] Univ Fed Ceara, Dept Quim Organ & Inorgan, Grp Bioinorgen, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil; [Abbadi, Bruno Lopes; Macchi, Fernanda Souza; Bizarro, Cristiano Valim] Pontificia Univ Catolica Rio Grande Do Sul PUCRS, Ctr Pesquisas Biol Mol & Func CPBMF, Porto Alegre, RS, Brazil; [Abbadi, Bruno Lopes; Macchi, Fernanda Souza; Bizarro, Cristiano Valim; Franca Lopes, Luiz Gonzaga; Silva Sousa, Eduardo Henrique] Inst Nacl Ciencia & Tecnol TB INCT TB, Porto Alegre, RS, Brazil; [Campos, Rafael de Morais; Abrantes Ferreira, Talles Luann; Falcao do Nascimento, Nilberto Robson] Univ Estadual Ceara, Lab Farmacol Cardiovasc & Renal, Campus Itaperi, BR-60714903 Fortaleza, Ceara, Brazil in 2020, Cited 40. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. SDS of cas: 98-97-5

A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release active species upon enzymatic oxidative activation, is devised. This is exemplified by combining two anti-mycobacterial drugs: pyrazinamide (first line) and delamanid (third line) whose active metabolites are pyrazinoic acid (PyzCOOH) and likely nitroxyl (HNO (or NO.)), respectively. Aiming to generate those active species, a hybrid compound was envisaged by coordination of pyrazine-2-hydroxamic acid (PyzCONHOH) with a Na-3[Fe-II(CN)(5)] moiety. The corresponding pentacyanoferrate(II) complex Na-4[Fe-II(CN)(5)(PyzCONHO(-))] was synthesized and characterized by several spectroscopic techniques, cyclic voltammetry, and DFT calculations. Chemical oxidation of this complex with H(2)O(2)was shown to induce the release of the metabolite PyzCOOH, without the need of theMycobacterium tuberculosis(Mtb) pyrazinamidase enzyme (PncA). Control experiments show that both H2O2- and N-coordinated pyrazine Fe(II)species are required, ruling out a direct hydrolysis of the hydroxamic acid or an alternative oxidative route through chelation of a metal center by a hydroxamic group. The release of HNO was observed using EPR spectroscopy in the presence of a spin trapping agent. The devised iron metal complex of pyrazine-2-hydroxamic acid was found inactive against an actively growing/non-resistantMtbstrain; however, it showed a strong dose-dependent and reversible vasodilatory activity with mostly lesser toxic effects than the reference drug sodium nitroprussiate, unveiling thus a potential indication for acute or chronic cardiovascular pathology. This is a priori a further indirect evidence of HNO release from this metal complex, standing as a possible pharmacophore model for an alternative vasodilator drug.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Carvalho, EM; Paulo, TD; Saquet, AS; Abbadi, BL; Macchi, FS; Bizarro, CV; Campos, RD; Ferreira, TLA; do Nascimento, NRF; Lopes, LGF; Chauvin, R; Sousa, EHS; Bernardes-Genisson, V or concate me.. SDS of cas: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

COA of Formula: C5H4N2O2. In 2020 CHEMISTRYSELECT published article about HELICOBACTER-PYLORI; BIOISOSTERIC TRANSFORMATIONS; TRIPLE THERAPY; PATHOGENESIS; METAANALYSIS; OXADIAZOLES; PREDICTION in [Azizian, Homa] Iran Univ Med Sci, Sch Pharm, Dept Med Chem, Int Campus, Tehran, Iran; [Esmailnejad, Atefeh; Fathi Vavsari, Vaezeh; Balalaie, Saeed] KN Toosi Univ Technol, Peptide Chem Res Ctr, POB 15875-4416, Tehran, Iran; [Mahernia, Shabnam; Amanlou, Massoud] Univ Tehran Med Sci, TIPS, Drug Design & Dev Res Ctr, Tehran, Iran; [Balalaie, Saeed] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran in 2020, Cited 42. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A number of pantoprazole derivatives were synthesized and screened for their urease inhibitory properties. Some of them showed potent inhibitions against jack bean urease. All compounds showed varying degree of IC50 in the range of 25.85 to 181 mu Mol as compared to standard acetohydroxamic acid (AHA) (100 +/- 2.02 mu Mol). Derivatives bearing 5-aryl-1,3,4-oxadiazole ring substitutions (aryl= pyrazyl, pyridyl and phenyl) were found to be more potent inhibitors than AHA and pantoprazole. The most promising compound, 2-((3,4-dimethoxypyridin-2-yl)methylthio)-5-(pyrazin-2-yl)-1,3,4-oxadiazole 12, with IC50 value of 25.85 +/- 1.21 showed remarkable urease inhibition activity. In silico molecular modeling investigation performed to rationalize the possible binding interaction and ADME properties of compounds over the active site of urease enzyme. The induced fit docking study showed that compound 12 interacted with conserved residues His593 and Arg609 located at the mouth of the urease active site flap and are essential for enzyme catalytic activity. These target compounds could be further studied as a lead skeleton for discovery of novel urease inhibitors.

COA of Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Azizian, H; Esmailnejad, A; Vavsari, VF; Mahernia, S; Amanlou, M; Balalaie, S or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem