Category: 98-97-5

HPLC of Formula: C5H4N2O2. Recently I am researching about KAURENE-TYPE ORIDONIN; BIOLOGICAL EVALUATION; NATURAL-PRODUCTS; STRUCTURAL MODIFICATION; DITERPENOID ANALOGS; NITROGEN MUSTARDS; SPIROLACTONE-TYPE; ANTICANCER; DERIVATIVES; APOPTOSIS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673306, 81703348, 81874289, 81903446]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20190564]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M652037]; Double First-Class University [CPU2018GY04, CPU2018GY35]; China Pharmaceutical University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yao, H; Xie, SW; Ma, XQ; Liu, JK; Wu, HY; Lin, AJ; Yao, HQ; Li, DH; Xu, ST; Yang, DH; Chen, ZS; Xu, JY. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic breast cancers without safe and effective therapeutic drugs. The natural product oridonin is reported to be a potential anti-TNBC agent. However, its moderate activity and complex structure hampered its clinical application. In this study, the novel oridonin analogues were first identified by removal of multiple hydroxyl groups and structural simplification of oridonin. The representative analogue 20 exhibited potent anticancer effects. Further structural modification on 20 generated the most potent derivative 56, which possessed 120-fold more potent antiproliferative activity than oridonin in the TNBC cell line HCC1806. Importantly, compound 56 exhibited more potent anticancer activity than paclitaxel in TNBC xenograft nude mice. Moreover, 56 could attenuate the expression of MMP-2, MMP-9, p-FAK, and integrin beta 1 to inhibit TNBC cell metastasis. All results suggest that compound 56 may warrant further investigation as a promising candidate agent for the treatment of TNBC.

HPLC of Formula: C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Yao, H; Xie, SW; Ma, XQ; Liu, JK; Wu, HY; Lin, AJ; Yao, HQ; Li, DH; Xu, ST; Yang, DH; Chen, ZS; Xu, JY or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors WOS:000482845600016 published article about CARFILZOMIB; DESIGN in [Lei, Meng; Miao, Hang; Feng, Huayun] Nanjing Forestry Univ, Coll Sci, 159 Longpan Rd, Nanjing 210037, Jiangsu, Peoples R China; [Zhang, Haoyang; Du, Xiao; Zhou, Hui; Wang, Xueyuan; Zhu, Yongqiang] Nanjing Normal Univ, Coll Life Sci, 1 Wenyuan Rd, Nanjing 210046, Jiangsu, Peoples R China; [Wang, Jia; Shi, Jingmiao; Liu, Zhaogang; Zhu, Yongqiang] Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, 9 Weidi Rd, Nanjing 210046, Jiangsu, Peoples R China; [Shen, Jian] Nanjing Normal Univ, Coll Chem & Mat Sci, 1 Wenyuan Rd, Nanjing 210046, Jiangsu, Peoples R China in 2019, Cited 21. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Name: Pyrazine-2-carboxylic acid

A series of novel tetrapeptidyl epoxyketone inhibitors of 20S proteasome was designed and synthesized. To fully understand the SAR, various groups at R-1, R-2, R-3, R-4 and R-5 positions, including aromatic and aliphatic substituents were designed, synthesized and biologically assayed. Based on the enzymatic results, seven compounds were selected to evaluate their cellular activities and soluble compound 36 showed strong potency against human multiple myeloma (MM) cell lines. Microsomal stability results indicated that compound 36 was more stable in mice, rat and human microsomes than marketed carfilzomib. The in vivo activities of this compound were evaluated with the xenograft mice models of MM cell lines ARH77 and RPMI-8226 with luciferase expression and the T/C value of the two models were 49.5% and 37.6%, respectively. To evaluate the potential cardiovascular toxicity, inhibition of hERG ion channel in HEK293 cells by compound 36 and carfilzomib was carried out. The results indicated that 36 had no binding affinity for the hERG ion channel while carfilzomib could bind it with IC50, of 92.1 mu M.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Lei, M; Zhang, HY; Miao, H; Du, X; Zhou, H; Wang, J; Wang, XY; Feng, HY; Shi, JM; Liu, ZG; Shen, J; Zhu, YQ or concate me.. Name: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Kelesoglu, A; Sigircik, G; Yildiz, R; Dehri, I in [Kelesoglu, Aysen; Sigircik, Gokmen; Dehri, Ilyas] Cukurova Univ, Fac Sci & Letters, Chem Dept, Adana, Turkey; [Yildiz, Resit] Mardin Artuklu Univ, Fac Hlth Sci, Dept Nutr & Dietet, Mardin, Turkey; [Yildiz, Resit] Mardin Artuklu Univ, Cent Res Lab, Mardin, Turkey published Inhibition efficiency of pyrazinecarboxylic acid on mild steel in acidic environment in 2021, Cited 62. Safety of Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Pyrazinecarboxylic acid (PCA) was examined as a potential corrosion inhibitor for mild steel (MS) in 0.5 M HCl environment. The methods of electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR), as well potentiodynamic (PD) polarization were utilized. Furthermore, atomic force microscopy (AFM) and quantum chemical calculations were utilized. PD polarization curves demonstrated that PCA exhibited mixed inhibitor behavior. Scanning electron microscopy (SEM) offered the creation of an adsorptive layer on the surface of MS which prevented the steel against corrosive specimens. Furthermore, density functional theory (DFT) presented good agreement with electrochemical experimental results. The adsorption equilibrium constant (k(ads)) value was calculated to be 3.704 x 10(4) M-1 which was related to a high proportion of inhibitor on the surface. In the presence of 1.0 mM PCA, inhibition efficiency was determined as 95.2% from EIS results.

Safety of Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Kelesoglu, A; Sigircik, G; Yildiz, R; Dehri, I or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about INHIBITORS; DISCOVERY; POTENT; ANGIOGENESIS; SAR, Saw an article supported by the National innovative drug incubation base project [2012ZX09401066]. Published in LIPPINCOTT WILLIAMS & WILKINS in PHILADELPHIA ,Authors: Huang, YZ; Zhang, Y; Li, JM; Ma, XD; Hu, MQ; Yang, Y; Gao, SF. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Category: Pyrazines

A novel structural series of tetrahydroisoquinoline-based compounds that incorporate the diaryl urea moiety was designed, synthesized, and biologically evaluated as suppressors of VEFGR-2 signaling. As a consequence, compounds 9k and 9s exhibited comparable or superior cytotoxic activity to that of gefitinib against the tested three cell lines, including A549, MCF-7, and PC-3. Importantly, both of them downregulated the expression of VEGFR-2, and inhibited VEGFR-2 phosphorylation at the concentration of 0.5 or 1.0 mu mol/ l. Besides, they suppressed human umbilical vein endothelial cell tube formation at the concentration of 4.0 mu mol/ l. Considering their capability of down-regulating VEGFR-2 expression and inhibiting VEGFR-2 phosphorylation, 9k and 9s may serve as suppressors of angiogenesis for further investigation. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Category: Pyrazines. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Huang, YZ; Zhang, Y; Li, JM; Ma, XD; Hu, MQ; Yang, Y; Gao, SF or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Quality Control of Pyrazine-2-carboxylic acid. Recently I am researching about FLUORESCENCE; SILVER; SURFACE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21875125, 21561023]; Natural Science Foundation of Inner Mongolia Autonomous Region of China [2017JQ03]; Scientific Research Project of Inner Mongolia Autonomous Region Higher Education Institutions [NJZY17455]; Program of High-level Talents of Inner Mongolia University [21300-5155104]; Scientific Research Project of Jining Normal University [jsky2018024]. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Zhao, YF; Wang, AL; Kang, J; Chu, HB; Zhang, HX; Zhao, YL. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Metal-enhanced luminescence (MEL) via Ag@SiO2 nanoparticles provides a promising strategy for the superior luminescence of lanthanide complexes. However, because of the delicate structure of the composites of Ag@SiO2 and complexes, it remains a great challenge to achieve the ideal MEL effect. Herein, five types of Ag@SiO2 nanoparticles with distinct core sizes (100 and 46 nm) and varied silica shell thickness (3, 24, 32, 52 and 55 nm) were prepared. Four kinds of lanthanide complexes RE(BA)(3)center dot H2O and RE(pyca)(3)center dot 2H(2)O (RE = Eu and Tb, BA = benzoate, pyca = 2-pyrazine carboxylate) were synthesized. A series of REL3-Ag@SiO2 (L = BA(-), pyca(-)) composite nanoparticles were prepared through the interaction of the Ag@SiO2 nanoparticles and the complexes. The adsorption of the complexes on the surface of Ag@SiO2 nanoparticles was confirmed by transmission electron microscope and energy dispersive X-ray spectroscopy. Luminescence property investigation showed that the factors affecting the MEL effect included the excitation and emission wavelength of lanthanide complexes, the kinds of lanthanide ions and organic ligands, as well as the core size and shell thickness of Ag@SiO2. Among these factors, the excitation wavelength of lanthanide complexes and the SiO2 shell thickness were found to play decisive roles. Finally, 25.92 times enhancement in luminescent intensity and 7.4 times increase in luminescence quantum yield can be achieved on Tb(BA)(3)center dot H2O by Ag@SiO2 with core size of 46 nm and shell thickness of 24 nm.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Zhao, YF; Wang, AL; Kang, J; Chu, HB; Zhang, HX; Zhao, YL or concate me.. Quality Control of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Discovery ofN-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B published in 2020. Recommanded Product: 98-97-5, Reprint Addresses Elkamhawy, A (corresponding author), Dongguk Univ Seoul, Coll Pharm, Goyang 10326, South Korea.; Roh, EJ (corresponding author), Korea Inst Sci & Technol KIST, Chem Kin Res Ctr, Seoul 02792, South Korea.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Herein, two new series ofN-substituted indole-based analogues were rationally designed, synthesizedviamicrowave heating technology, and evaluated as noteworthy MAO-B potential inhibitors. Compared to the reported indazole-based hitsVIandVII, compounds4band4eexhibited higher inhibitory activities over MAO-B with IC(50)values of 1.65 and 0.78 mu M, respectively. When compared to the modest selectivity index of rasagiline (II, a well-known MAO-B inhibitor, SI > 50), both4band4ealso showed better selectivity indices (SI > 60 and 120, respectively). A further kinetic evaluation of the most potent derivative (4e) displayed a competitive mode of inhibition (inhibition constant (K-i)/MAO-B = 94.52 nM). Reasonable explanations of the elicited biological activities were presentedviaSAR study and molecular docking simulation. Accordingly, the remarkable MAO-B inhibitory activity of4e(N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.

Recommanded Product: 98-97-5. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Elkamhawy, A; Paik, S; Kim, HJ; Park, JH; Londhe, AM; Lee, K; Pae, AN; Park, KD; Roh, EJ or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recently I am researching about PHARMACOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ACCURATE DOCKING; OXAZOLIDINONE; OXADIAZOLES; DESIGN; GLIDE, Saw an article supported by the . SDS of cas: 98-97-5. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

SDS of cas: 98-97-5. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Computed Properties of C5H4N2O2. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Cell-Based Optimization of Covalent Reversible Ketoamide Inhibitors Bridging the Unprimed to the Primed Site of the Proteasome beta 5 Subunit published in 2019, Reprint Addresses Schmidt, B (corresponding author), Tech Univ Darmstadt, Clemens Schoepf Inst Organ Chem & Biochem, Alarich Weiss Str 4, D-64287 Darmstadt, Germany.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid.

The ubiquitin-proteasome system (UPS) is an established therapeutic target for approved drugs to treat selected hematologic malignancies. While drug discovery targeting the UPS focuses on irreversibly binding epoxyketones and slowly-reversibly binding boronates, optimization of novel covalent-reversibly binding warheads remains largely unattended. We previously reported alpha-ketoamides to be a promising reversible lead motif, yet the cytotoxic activity required further optimization. This work focuses on the lead optimization of phenoxy-substituted alpha-ketoamides combining the structure-activity relationships from the primed and the non-primed site of the proteasome beta 5 subunit. Our optimization strategy is accompanied by molecular modeling, suggesting occupation of P1 ‘ by a 3-phenoxy group to increase beta 5 inhibition and cytotoxic activity in leukemia cell lines. Key compounds were further profiled for time-dependent inhibition of cellular substrate conversion. Furthermore, the alpha-ketoamide lead structure 27 does not affect escape response behavior in Danio rerio embryos, in contrast to bortezomib, which suggests increased target specificity.

Computed Properties of C5H4N2O2. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Stubba, D; Bensinger, D; Steinbacher, J; Proskurjakov, L; Gomez, AS; Schmidt, U; Roth, S; Schmitz, K; Schmidt, B or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Name: Pyrazine-2-carboxylic acid. In 2019 CHEMISTRYSELECT published article about PARASITIC NEMATODE; CHITINASE; COUMARINS; DRUG in [Priyanka; Tiwari, Neha; Sharma, Rajesh K.; Katiyar, Diksha] Banaras Hindu Univ, Dept Chem, MMV, Varanasi 221005, Uttar Pradesh, India; [Neelabh; Singh, Karuna] Banaras Hindu Univ, Dept Zool, MMV, Varanasi 221005, Uttar Pradesh, India; [Gupta, Poonam] Mahanand Miss Harijan Coll, Dept Chem, Ghaziabad 201001, India; [Misra, Sweta; Misra-Bhattacharya, Shailja] CSIR, Cent Drug Res Inst, Div Parasitol, BS 10-1,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Butcher, Ray J.] Howard Univ, Dept Chem, 525 Coll St NW, Washington, DC 20059 USA in 2019, Cited 28. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A series of 7-benzamidocoumarin derivatives 10-25 starting from 7-amino coumarins 7 and 8 has been synthesized, characterized and evaluated in vitro for antifilarial activity against the human lymphatic filarial parasite, Brugia malayi. Compounds 13 and 20-23 showed permanent paralysis of the worm with 90-95% inhibition of motility of adult worms at 10 mu M. All the synthesized compounds were docked on the modeled receptor of Onchocerca volvulus chitinase OvCHT1. Compound 13 with binding energy of -7.95 Kcal/mol showing three hydrogen bonds with the active site of the enzyme emerged as the best inhibitor.

Name: Pyrazine-2-carboxylic acid. About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Priyanka; Neelabh; Tiwari, N; Sharma, RK; Gupta, P; Misra, S; Misra-Bhattacharya, S; Butcher, RJ; Singh, K; Katiyar, D or concate me.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

COA of Formula: C5H4N2O2. In 2019 ACTA CRYSTALLOGR E published article about CU-II COMPLEX; MOLECULAR-STRUCTURE; MAGNETIC-PROPERTIES in [Cati, Dilovan S.] Debiopharm Int SA, Chemin Messidor 5-7,CP 5911, CH-1002 Lausanne, Switzerland; [Stoeckli-Evans, Helen] Univ Neuchatel, Inst Phys, Rue Emile Argand 11, CH-2000 Neuchatel, Switzerland in 2019, Cited 31. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

The title tridentate ligand, C14H10N4O, N-(quinolin-8-yl) pyrazine-2-carboxamide (HL1), crystallizes with three independent molecules (A, B and C) in the asymmetric unit. All three molecules are relatively planar (r.m.s. deviations are 0.068, 0.055 and 0.06 angstrom, respectively), with the NH H atom forming three-centered (bifurcated) intramolecular N-H center dot center dot center dot N hydrogen bonds in each molecule. There is also an intramolecular C-H center dot center dot center dot O contact present in each molecule, involving the benzene ring of the quinoline unit and the amide carboxamide O atom. In the crystal, the three molecules stack in columns with the various molecules being linked by offset pi-pi interactions [intercentroid distances vary from 3.367 (5) to 3.589 (5) angstrom], forming layers parallel to the ab plane. The title complex, [Cu-4(C42H44N8O16)]center dot 2CH(3)OH, {hexa-mu-acetato-1: 2 kappa O-2:O’;2:3 kappa O-8:O’;3:4 kappa O-2:O’-dimethanol-1 kappa O, 2 kappa O-bis[N-(quinolin-8-yl) pyrazine-2-carboxamide]-1 kappa N-3, N’, N ”; 4 kappa(3) N, N’, N ”-tetracopper(II) methanol disolvate} (I), was obtained by the reaction of HL1 with Cu(CH3CO2)(2). It consists of a tetranuclear complex with a central tetrakis(mu-acetato) dicopper paddle-wheel moiety linked on either side via bridging acetato ions to a mononuclear copper(II)-(L1) complex; it crystallizes as a methanol disolvate. The complex possesses inversion symmetry, being located about a center of symmetry situated at the mid-point of the Cu center dot center dot center dot Cu bond of the paddle-wheel moiety. In the crystal, the complex molecules are linked by O-H center dot center dot center dot O hydrogen bonds, forming chains along the [01 (1) over bar] direction, which are linked by offset pi-pi interactions [intercentroid distance = 3.7367 (11) angstrom] and C-H center dot center dot center dot O hydrogen bonds, leading to the formation of a supramolecular framework.

About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Cati, DS; Stoeckli-Evans, H or concate me.. COA of Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem