Meti, Puttavva published the artcileRegioselective synthesis of dipyrrolopyrazine (DPP) derivatives via metal free and metal catalyzed amination and investigation of their optical and thermal properties, Safety of 5-Bromo-3,6-dichloropyrazin-2-amine, the main research area is dipyrrolopyrazine derivative preparation regioselective; dihalo pyrrolopyrazine alkyne metal catalyst amination reaction.
An efficient methods for the synthesis of dipyrrolopyrazine derivatives, I [R1 = H, C6H5; R2 = C6H5, 4-F-C6H4, (CH3)2NC6H4, cyclopropyl, etc.] and II and pyrrolothieno-pyrazine derivatives, III (X = H, C6H5) that involve regioselective amination reactions of dihalo-pyrrolopyrazines IV [Y = H, CH3, 4-CH3C6H4S(O)2; A = Br; B = Cl] is reported. The developed protocol readily affords either 2-amino- or 3-amino-pyrrolopyrazines IV (A = Br, NHCH3; B = Cl, NHCH3) from the corresponding 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines IV (A = Br; B = Cl). When the amination reactions was carried under metal-free microwave irradiation, 3-amino-pyrrolopyrazines IV (A = Br; B = NHCH3) was obtained exclusively. In contrast, Buchwald cross coupling of the 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines IV (A = Br; B = Cl) affords only 2-amino-pyrrolopyrazine IV (A = NHCH3; B = Cl). The pyrrolopyrazine scaffolds was converted to the resp. 1,7- I and 1,5-dihydrodipyrrolo[2,3-b]pyrazines derivatives II using Sonogashira reactions. A comprehensive study of the optical properties, thermal properties, and mol. packing of the synthesized compounds was carried out. The results indicate that the 1,7-derivatives I may be promising organic materials for optoelectronic applications.
RSC Advances published new progress about Amination. 960510-36-5 belongs to class pyrazines, name is 5-Bromo-3,6-dichloropyrazin-2-amine, and the molecular formula is C4H2BrCl2N3, Safety of 5-Bromo-3,6-dichloropyrazin-2-amine.