Category: 957344-74-0

Some common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 957344-74-0

A mixture of known compound 7 (2.75g, 9.90mmol), cyclopropylamine (3.4mL, 49.50mmol) and N, N-diisopropylethylamine (3.5mL, 19.80mL) in 1,4-dioxane (33mL) was stirred at 100C for 16h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated aqueous NaHCO3. The organic phase was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo. The residue was purified by column chromatography (Hexanes:EtOAc=1:2) to afford the title compound 9 (2.3g, 92%). 1H NMR (300MHz, DMSO-d6) delta 7.88 (s, 1H), 7.82 (br, 1H), 7.58 (s, 1H), 7.49 (s, 1H), 2.85 (m, 1H), 0.68 (m, 2H), 0.63 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 957344-74-0, its application will become more common.

Reference:
Article; Kang, Seok Jong; Lee, Jung Wuk; Chung, Shin Hyuck; Jang, Sun Young; Choi, Jaeyul; Suh, Kwee Hyun; Kim, Young Hoon; Ham, Young Jin; Min, Kyung Hoon; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 660 – 670;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5,8-Dibromoimidazo[1,2-a]pyrazine

Step 3 (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-[6-(4-isopropyl-piperazin-l-yl)-pyridin-3-yl] -amine[00410] To a solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (0 85g, 3 lmmol) in isopropanol are added 6-(4-isopropyl-piperazin-l-yl)-pyridm-3-yl-amme (0 68g, 3 lmmol) and dnsopropylethylamme (0 6mL, 4 6mmol) and the mixture is stirred at 900C for 48 hours The solvent is removed in vacuo and the product taken up in DCM-10% cit?c acid The organic layer is discarded and the aqueous solution basified with sat NaHCO3 (pH 7-8) and extracted using DCM The organic layer is d?ed over MgSO4, filtered and concentrated in vacuo to afford the title compound as a purple solid (0 92g, 71%) HPLC (254nm) Rt 3 30mm (95 8%), m/z 416/418 (M+H)+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 957344-74-0.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 957344-74-0, These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5,8-dibromoimidazo[1,2-a]pyrazine (2.75 g, 9.90 mmol) prepared in step 1, cyclopropylamine (3.4mL, 49.50 mmol),N, N- diisopropylethylamine to (3.5 mL, 19.80 mmol) was dissolved in 1,4-dioxane (33 mL), the mixture at 100C stirred for 16 hours.Neutralized by addition of a saturated aqueous solution of sodium bicarbonate to the reaction solution and ethyl acetateExtracted with Tate.The extracted organic layer was washed with water. The organic layer was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by column chromatography (ethyl acetate: n- hexane = 1: 1) to give the title compound (530 mg, 92%)

The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HANMI PHARM. CO., LTD.; HAM, YOUNG JIN; SON, JUNG BEOM; PARK, CHANG HEE; KANG, SEOK JONG; CHOI, JAE YUL; KIM, SEO HEE; (36 pag.)KR2015/113801; (2015); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 957344-74-0, The chemical industry reduces the impact on the environment during synthesis 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.

Step 1 (5-Bromo-iotamiotadazo[ 1 , 2-a]pyraziotan-8-yl)-(4-methanesulfonyl-phenyl) -amine[00270] A degassed mixture of 5,8-dibromo-imidazo[l,2-a]pyrazme (2.19g, 7.916mmol), A- methylsulfonylamlme (1 49g, 8.708mmol), Pd2dba3 (145mg, 0.15mmol) and Xantphos (183mg, 0.317mmol), m dry toluene (5OmL) is stirred at 1100C for 16 hours. After evaporation of the solvent, the residue is purified by silica gel column chromatography elutmg with 95:5 DCM:NH3 (7M in MeOH). The title compound (1.496g, 51%) is isolated containing some starting material (20%) and used in the next step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 957344-74-0, These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Typical example of compound of formula (E).General procedure for amine displacement[00251] Amine (1.5eq , 10 8mmol) and (1.5eq, 10.8mmol) are added to a solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (1.99g, 7.2mmol) m ethanol (6mL), and the reaction stirred at 800C for 15 hours. Ethanol is removed in vacuo and the product taken up m DCM and washed with water, dried over MgSO4 and concentrated in vacuo. The resultant oil is passed through a pad of silica using DCM and concentrated in vacuo to yield the desired product; Synthesis of Intermediates Intermediate 1: (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-(4-chloro-phenyl)-amine.[00254] Following the general procedure for amine displacement 5,8-dibromo-imidazo[l,2- ajpyrazme (1 99g, 7 2mmol) and 4-chloroamlme (1 37g, 10 8mmol) are coupled to give the title compound Purification on silica gel with dichloromethane, methanol (98 2) gives the final product [00255] HPLC (254nm) Rt 3 04mm (100%), m/z (APCI) 323, 325, 327 (M+H)+, 1H NMR(250MHz, CDCl3) delta(ppm) 7 32-7 36 (2H, m), 7 56 (IH, s), 7 64 (IH, m), 7 76-7 80 (3H, m), 7 96 (IH, br s)

Statistics shows that 5,8-Dibromoimidazo[1,2-a]pyrazine is playing an increasingly important role. we look forward to future research findings about 957344-74-0.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 957344-74-0, A common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 4-(5-Bromoiotamiotadazo[l,2-a]pyraziotan-8-ylamiotano) benzoic acid methyl ester[00266] A mixture of 5,8-dibromoimidazo[l,2-a]pyrazme (2g, 7 3mmol), 4-amino benzoic acid methyl ester (0 93g, 6 2mmol), NaO’Bu (0 98g, 10 2mmol), Pd2(dba)3 (133mg, 0 14mmol), Xantphos (168mg, 0 29mmol) and toluene is degassed with nitrogen, then heated at 850C for 18 hours The toluene is removed in vacuo, then MeOH is added to the crude residue The solid is collected by filtration and dried in the vacuum oven The solid is identified as the desired title ester The filtrate is chromatographed with petrol EtOAc (70 30 followed by 50 50) and the fractions containing the desired product, combined, evaporated and triturated with MeOH The resultant solid is collected by filtration and is also identified as the desired ester

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 957344-74-0,Some common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-[4-(l-methyl-piperidin-4-ylmethoxy)-phenyl] -amine[00319] To a solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (0.100g, 0.36mmol) in isopropanol (5mL) are added l,4-diazabicyclo[2,2,2]octane (DABCO) (0.036mL, 0 36mmol) and 4-(l- methyl-pipe?dm-4-ylmethoxy)-phenylamme (79 6mg, 0 36mmol) The reaction mixture is stirred at9O0C overnight The solvent is evaporated and the residue chromatographed on silica gel column elutmg with 97 3 followed by 94 6 and 90 10 DCM MeOH The title compound is obtained as a solid(20mg, 13%) LCMS Rt 2 30mm (94%), m/z (APCI) 417

The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 957344-74-0, These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3 (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-[4-(4-isopropyl-piperazin-l-yl)-phenyl] -amine[00395] A solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (0 134g, 0 48mmol), 4-(4-isopropyl- piperazm-l-yl)-phenylamine (0 118g, 0 54mmol) and dnsopropylethylamme (0 093mL, 0 54mmol) is stirred at 9O0C for 18 hours The reaction mixture is concentrated in vacuo and partitioned between DCM and sat NaHCO3 The organic layer is washed with brine, d?ed over MgSO4, filtered and concentrated The residue is pu?fied by silica gel column chromatography eluting with 98 2 DCM MeOH to afford the title compound (0 086 g, 43%)

The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H3Br2N3

Step 3 4-(5-Bromo-iotamiotadazo[l 2-a]pyraziotan-8-ylamiotano)-2-methoxy-N-(6-methylpyriotadiotan-3-ylmethyl) benzamide[00367] 5,8-dibromoimidazo[l,2-a]pyrazme (285 mg, 1 03 mmol) and 4-ammo-2-methoxy-/V-[(6-methylpy?dm-3-yl)methyl]benzamide (280 mg, 1 03 mmol) are stirred in 1PrOH (5 mL) and HBr (48% aq , 380 muL) is added The mixture is heated at reflux for 24 hours The cooled suspension is poured into NaHCO3 (sat aq , 25 mL) and water (25 mL) and extracted with CHCI3 (3 x 40 mL) The extracts are dried over MgStheta4 and evaporated The residue is purified by column chromatography, elutmg with 10% – 20% DCM/MeOH to afford the title compound as a pale yellow solid (200 mg, 0 43 mmol)

The synthetic route of 5,8-Dibromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 957344-74-0, The chemical industry reduces the impact on the environment during synthesis 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.

Step 3 (5-Bromoimidazo[l,2-a]pyrazin-8-yl)-(4-(4-methylpiperazin-l-yl)phenylamine[00292] 4-(4-Methylpiperazin-lyl)phenylamine (5 08g, 26 6mmol) and NN- diisopropylethylamine (4 6mL, 26 6mmol) and 5,8-dibromoimidazo[l,2-a]pyrazine (6 Ig, 22 2mmol) in iso-propanol (15OmL), is heated at 900C for 2 days The solvent is removed in vacuo, and the crude residue partitioned between DCM and IN NaOH The organic phase is separated, then washed with water followed by brine. The organic layer is separated, dried (MgSO4) and evaporated. The crude residue is chromatographed on silica gel, eluting with DCM followed by 96:4 DCM NH 3 (7M in MeOH), and the fractions containing the desired product are combined and evaporated The residue is t?turated with Et2theta to afford the title compound as a solid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem