A common compound: 95-89-6, name is 3-Chloro-2,5-dimethylpyrazine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 95-89-6
In a pressure tube were placed 4 mL of 25% ammonia solution, 64 mg of powdered copper and 1.0 g (6.66 mmol) of 3-chloro-2,5-dimethylpyrazine. The whole was heated to 150 C for 18 hours. Further 1 mL of 25% ammonia solution was added and heating was continued for further 4 hours. The mixture was filtered through silica gel layer, washed with 10 mL of water and 10 mL of ethyl acetate. The filtrate was extracted with ethyl acetate (5 x 10 mL). Organic phase was dried over sodium sulphate and concentrated. Resulted solid was triturated with heptane and filtered-off (first crop). Second crop of the product crystallized from the filtrate. Combined solids were dried under reduced pressure to obtain 0.60 g of 2-amino-3,6-dimethyl- pyrazine as a solid (yield 73%). MR (300 MHz, DMSO-d6): delta 7.45 (s, 1H), 6.01 (s, broad, 2H), 2.22 (s, 3H), 2.10 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 95-89-6, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CELON PHARMA S.A.; MOSZCZYNSKI-PETKOWSKI, Rafal; BOJARSKI, Lukasz; WIECZOREK, Maciej; MAJER, Jakub; JANOWSKA, Sylwia; MATLOKA, Mikolaj; BORKOWSKA, Malgorzata; STEFANIAK, Filip; LAMPARSKA-PRZYBYSZ, Monika; DUBIEL, Krzysztof; WO2015/177688; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem