Category: 937669-80-2

Synthetic Route of 937669-80-2,Some common heterocyclic compound, 937669-80-2, name is 3-Bromopyrazine-2-carboxylic acid, molecular formula is C5H3BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 6-(4,6-dimethylpyrimidin-2-yl)-3 ,6-diazabicyclo [3.2.1 ]octane 10-2 (150 mg, 0.69 mmol), 3-bromopyrazine-2-carboxylic acid (167 mg, 0.83 mmol), EDC (198 mg, 1.03mmol), HOAt (140 mg, 1.03 mmol), and N,N-diisopropylethylamine (0.36 mL, 2.06 mmol) in acetonitrile (1 mL) was stirred at room temperature for 24 h. The reaction was concentrated in vacuo and the crude residue was purified by silica gel chromatography (0-100% EtOAc/hexanes, 20 mm) to give 48-1 as an oil. MS (ESI) mlz: 403.3 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromopyrazine-2-carboxylic acid, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; REGER, Thomas, S.; ROECKER, Anthony, J.; (0 pag.)WO2016/85783; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 937669-80-2, name is 3-Bromopyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937669-80-2, COA of Formula: C5H3BrN2O2

In a 500 mL three-necked flask, 3-bromopyrazine-2-carboxylic acid (20.3 g, 0.1 mol) was dissolved in 200 ml of methanol, and 20 ml of concentrated sulfuric acid having a concentration of 98 wt% was added dropwise to the reaction solution.After stirring at room temperature for 12 hours, the reaction was quenched, the reaction was quenched with EtOAc (EtOAc)EtOAc.A mixed solvent of petroleum ether/dichloromethane (volume ratio of 2/1) was used as a rinse agent, and the yield was 83%.

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Reference:
Patent; South China Xietong Chuangxin Institute; Ying Lei; Hu Liwen; Huang Fei; Cao Yong; (22 pag.)CN108218891; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem