93049-39-9 Archives

Brief introduction of 93049-39-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Chloropyrido[3,4-b]pyrazine, its application will become more common.

Application of 93049-39-9,Some common heterocyclic compound, 93049-39-9, name is 7-Chloropyrido[3,4-b]pyrazine, molecular formula is C7H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 417- [3 -(Piperidin- 1 -ylmethv0phenyl1pyrido[3 ,4-61pyrazine4,5-Diamino-2-chloropyridine (35 mg, 0.24 mmol) was dissolved in ethanol (1 mL) and glyoxal (0.5 niL, 40% in water) was added. After standing for 18 h the mixture was partitioned between water and EtOAc (20 mL each). The organic phase was washed with water, dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DME (0.7 mL), and 3-(piperidin-l-ylmethyl)phenylboronic acid pinacol ester hydrochloride (81 mg, 0.24 mmol), 2M aqueous sodium carbonate solution (0.35 mL, 0.7 mmol) and Pd(PPh3)4 (8 mg, 0.007 mmol) were added. The mixture was heated to 12O0C in a sealed tube, under microwave irradiation, for 20 minutes. After cooling, the mixture was partitioned between water and EtOAc (2 mL each). The organic phase was concentrated in vacuo and the residue was purified by preparative HPLC to give the title compound (53 mg, 64%) as a pale yellow gum. deltaH (CDCl3) 9.63 (d, IH), 9.03 (d, IH), 8.92 (d, IH), 8.37 (d, IH), 8.17 (s, IH), 8.08-8.14 (m, IH), 7.44-7.57 (m, 2H), 3.74 (s, 2H), 2.50-2.65 (m, 4H), 1.59-1.73 (m, 4H), 1.40-1.54 (m, 2H). LCMS (ES+) 305 (M+H)+, RT 1.89 minutes.

Reference:
Patent; UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne; WO2010/52448; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

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The chemical industry reduces the impact on the environment during synthesis 7-Chloropyrido[3,4-b]pyrazine. I believe this compound will play a more active role in future production and life.

Electric Literature of 93049-39-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 93049-39-9, name is 7-Chloropyrido[3,4-b]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.

INTERMEDIATE 383-(Pyridor3,4-&1pyrazin-7-ylN)benzaldehyde 7-Chloropyrido[3,4-Z?]pyrazine (140 mg, 0.85 mmol), 3-formylbenzeneboronic acid (127 mg, 0.85 mmol), potassium phosphate (180 mg, 0.85 mmol), water (2 mL), DME (6 mL) and Pd(PPh3)4 (100 mg, 0.085 mmol) were combined in a sealed tube and heated under microwave irradiation to 1400C for 30 minutes. The reaction mixture was then partitioned between ethyl acetate and water. The organic layer was dried (MgSO4) and concentrated to dryness to give the title compound (155 mg, 77%) as an off-white solid. deltaH (DMSOd6) 10.21 (IH, s), 9.69 (IH, s), 9.26 (IH, d, J 1.82 Hz), 9.15 (IH, d, J 1.83 Hz), 8.93 (IH, s), 8.76 (IH, s), 8.70 (IH, d, J 7.80 Hz), 8.07 (IH, d, J 7.61 Hz), 7.84 (lH, t, J7.68 Hz).

The chemical industry reduces the impact on the environment during synthesis 7-Chloropyrido[3,4-b]pyrazine. I believe this compound will play a more active role in future production and life.

The important role of 93049-39-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 93049-39-9, its application will become more common.

Some common heterocyclic compound, 93049-39-9, name is 7-Chloropyrido[3,4-b]pyrazine, molecular formula is C7H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H4ClN3

EXAMPLE 1117-[3-(Pyrrolidin-l-ylmethyl)phenyllpyrido[3,4-Z>lpyrazineA mixture of 3-(bromomethyl)phenylboronic acid (150 mg, 0.69 mmol), pyrrolidine (70 muL, 0.84 mmol) and potassium phosphate (440 mg, 2.10 mmol) in DME (3 mL) was heated at 8O0C in a sealed reaction tube for 16 h. The reaction mixture was cooled to room temperature. 7-Chloropyrido[3,4-d]pyrazine (110 mg, 0.69 mmol), Pd(PPh3)4 (40 mg, 0.035 mmol) and water (0.5 mL) were then added. The resulting mixture was purged with nitrogen for 5 minutes, sealed and heated at 850C for 16 h. After cooling to room temperature, the mixture was diluted with ethyl acetate (5 mL) and filtered through Celite. The filtrate was concentrated to dryness and purified by preparative HPLC to give the title compound (12.0 mg, 6%) as a pale brown solid. 5H (CDCl3) 9.62 (IH, s), 9.02 (IH, d, J 1.78 Hz), 8.91 (IH, d, J 1.78 Hz), 8.37 (IH, s), 8.22 (IH, s), 8.13 (IH, dt, J 6.69, 2.04 Hz), 7.58-7.48 (2H, m), 3.96 (2H, s), 2.70-2.84 (4H, m), 2.03-1.79 (4H, m). LCMS (ES+) 291 (M+H)+, 9.83 minutes {Method 5).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 93049-39-9, its application will become more common.