COA of Formula: C8H8N4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, is researched, Molecular C8H8N4, CAS is 91912-53-7, about Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Author is Di Grandi, Martin J.; Berger, Dan M.; Hopper, Darrin W.; Zhang, Chunchun; Dutia, Minu; Dunnick, Alejandro L.; Torres, Nancy; Levin, Jeremy I.; Diamantidis, George; Zapf, Christoph W.; Bloom, Jonathan D.; Hu, YongBo; Powell, Dennis; Wojciechowicz, Donald; Collins, Karen; Frommer, Eileen.
A novel series of pyrazolo[1,5-a]pyrimidines bearing a 3-hydroxyphenyl group at C(3) and substituted tropanes at C(7) have been identified as potent B-Raf inhibitors. Exploration of alternative functional groups as a replacement for the C(3) phenol demonstrated indazole to be an effective isostere. Several compounds possessing substituted indazole residues, such as 4e, 4p, and 4r, potently inhibited cell proliferation at submicromolar concentrations in the A375 and WM266 cell lines, and the latter two compounds also exhibited good therapeutic indexes in cells.
As far as I know, this compound(91912-53-7)COA of Formula: C8H8N4 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.