Category: 91775-62-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91775-62-1, name is 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6BrN3O

To a degassed mixture of 3-bromo-8-methoxyimidazo[1,2a]pyrazine (1.4g, 6.2mmol), cyclopropylboronic acid (0.8g, 9.3 mmol) potassium phosphate (4.6g, 21.Smmol) in water (5m1) and toluene (30m1), was added Palladium(ii)acetate and tricyclohexyl phosphine. The resulting reaction mixture was stined at 90C for 12h. The reaction mixture was cooled and partitionedbetween ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to get the crude product. The crude product was purified by column chromatography (230-400 mesh silica gel and 10- 30% EtOAc in hexane) to obtain 3-cyclopropyl-8-methoxyimidazo[ 1 ,2-a]pyrazine (1 .0g, 91%). ?H NMR (300 MHz,CDC13): oe 7.79 (d, J= 4.8 Hz, 1H), 7.41 (d, J= 4.8 Hz, 1H), 7.33 (s, 1H),4.13 (s, 3H),1.84 – 1.83 (m, 1H), 1.07 – 1.02(m, 2H) 0.77 – 0.73(m,2H); LC-MS: 190.3 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; KOTRABASAIAH UJJINAMATADA, Ravi; PANDIT, Chetan; (152 pag.)WO2016/185342; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91775-62-1, name is 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine

To a degassed mixture of 3-bromo-8-methoxyimidazo[1,2a]pyrazine (1.4g, 6.2mmol), cyclopropylboronic acid (0.8g, 9.3 mmol) potassium phosphate (4.6g, 21.Smmol) in water (5m1) and toluene (30m1), was added Palladium(ii)acetate and tricyclohexyl phosphine. The resulting reaction mixture was stined at 90C for 12h. The reaction mixture was cooled and partitionedbetween ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to get the crude product. The crude product was purified by column chromatography (230-400 mesh silica gel and 10- 30% EtOAc in hexane) to obtain 3-cyclopropyl-8-methoxyimidazo[ 1 ,2-a]pyrazine (1 .0g, 91%). ?H NMR (300 MHz,CDC13): oe 7.79 (d, J= 4.8 Hz, 1H), 7.41 (d, J= 4.8 Hz, 1H), 7.33 (s, 1H),4.13 (s, 3H),1.84 – 1.83 (m, 1H), 1.07 – 1.02(m, 2H) 0.77 – 0.73(m,2H); LC-MS: 190.3 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; KOTRABASAIAH UJJINAMATADA, Ravi; PANDIT, Chetan; (152 pag.)WO2016/185342; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 91775-62-1, name is 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 91775-62-1, Product Details of 91775-62-1

To a well stined solution of silver(I)fluoride (3.4g, 26.5 mmol) in DMF (20 ml), wasadded trifluoromethyltrimethylsilane and stined at room temperature for 0.5h. To the reactionmixture, was added copper (2.4g, 39.0 mmol) and stined at room temperature for 4h. Then added 3-bromo-8-methoxyimidazo[1,2-a]pyrazine (5.5g, 24.1 mmol) and stined at 90C for 5h. The reaction mixture was cooled and partitioned between ethyl acetate and water. The organic layer was washed with water, brine, dried over anhydrous sodium sulfate and concentrated underreduced pressure to get the crude product. The crude product was purified by column chromatography (60-120 mesh silica gel and 10- 20% EtOAc in hexane) to obtain 8-methoxy-3- (trifluoromethyl)imidazo[ 1 ,2-a]pyrazine (1 .5g, 29%). LC-MS: 218.3 [M+Hf.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, and friends who are interested can also refer to it.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; KOTRABASAIAH UJJINAMATADA, Ravi; PANDIT, Chetan; (152 pag.)WO2016/185342; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 91775-62-1, name is 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Bromo-8-methoxyimidazo[1,2-a]pyrazine

A suspension OF 3-BROMO-8-METHOXYIMIDAZO [1, 2-A] PYRAZINE (1. 6 g, 7 mmol) in hydrogen bromide (30 wt % in acetic acid, 15 ml) was heated at 80C for 90 min. The reaction was cooled, diluted with water (75 ml) then neutralised with solid sodium hydrogencarbonate. The resulting solid was collected by filtration, washed with water then dried under vacuum to afford 3-BROMO-7H-IMIDAZO [1, 2- A] PYRAZIN-8-ONE as a white powder:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.