Category: 89283-32-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: 89283-32-9

1.44 g of 3-chloro-2-pyrazine methanol, 2 mol% of vanadium nitrate (relative to the substrate 3-chloro-2-pyrazine methanol),Add to the 50mL reaction tube, Add 5mL of acetonitrile,Fill the air ball, close the reaction tube, and raise the temperature to 40 C with stirring.And kept for 10 h, until the reaction is over, and cooled to room temperature.Sampling was analyzed using gas chromatography.The conversion rate of 3-chloro-2-pyrazine methanol is 96.1%.The selectivity of 3-chloro-2-pyrazinecarboxaldehyde is greater than 99%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dalian University of Technology; Du Zhongtian; Tang Yangyang; Sun Xiaowan; Yue Jiajia; (6 pag.)CN106866508; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89283-32-9 as follows. Recommanded Product: 89283-32-9

[0291] To a mixture of(3-chloropyrazin-2-yl)methanol (200 mg, 1.4 mmol, 1 eq.), 1- isopropyl-5-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)-1H-pyrazole (393 mg, 1.67 mmol, 1.2eq.), Pd(dppf)C12 (102 mg, 0.14 mmol, 0.1 eq.), and K2C03 (580 mg, 4.2 mmol, 3 eq.) in aRB flask were added dioxane (6 mL) and water (2 mL). The mixture was heated at 100 C for 1 h, cooled to rt, filtered, concentrated, and purified on silica gel using a mixture of EtOAc and hexanes as eluent to give (3-( 1 -isopropyl- 1 H-pyrazol-5-yl)pyrazin-2-yl)methanol (110 mg, 36%) as a yellow oil. LRMS(M+H+ ] m/z 219.1.

According to the analysis of related databases, 89283-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley; WO2013/102145; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C5H5ClN2O

Step 2 To a mixture of (3-chloropyrazin-2-yl)methanol (200 mg, 1.4 mmol, 1 eq.), 1-isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (393 mg, 1.67 mmol, 1.2 eq.), Pd(dppf)Cl2 (102 mg, 0.14 mmol, 0.1 eq.), and K2CO3 (580 mg, 4.2 mmol, 3 eq.) in a RB flask were added dioxane (6 mL) and water (2 mL). The mixture was heated at 100 C. for 1 h, cooled to rt, filtered, concentrated, and purified on silica gel using a mixture of EtOAc and hexanes as eluent to give (3-(1-isopropyl-1H-pyrazol-5-yl)pyrazin-2-yl)methanol (110 mg, 36%) as a yellow oil. LRMS (M+H+) m/z 219.1.

The synthetic route of (3-Chloropyrazin-2-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Global Blood Therapeutics, Inc.; The Regents of the University of Califorina; Cytokinetics, Inc.; Metcalf, Brian; Chuang, Chihyuan; Warrington, Jeffrey; Paulvannan, Kumar; Jacobson, Matthew P.; Hua, Lan; Morgan, Bradley; US2015/344483; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, molecular formula is C5H5ClN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 89283-32-9

2-Chloro-3-chloromethyl-pyrazine: (3-Chloropyrazin-2-yl)-methanol (8.00 g, 0.0553 mol) was dissolved in toluene (40 mL) and N,N-dimethylformamide (2.1 mL, 0.028 mol). The solution was treated dropwise with thionyl chloride (4.44 mL, 0.0609 mol) over 10 min, keeping the temperature at 40 C. during the addition. After 30 min the reaction was quenched with 20 mL water and then solid sodium carbonate (7.7 g, 0.073 mol) was added to give a neutral pH. The mixture was filtered and the toluene layer was separated. The aqueous layer was re-extracted with 25 mL toluene and the combined toluene extracts were washed with water (25 mL). The toluene solution was evaporated to remove water. The product can be used without further purification or if desired purified by distillation at 58 C. (1 Torr) to give the title compound a colorless liquid. 1H NMR (CDCl3, 400 MHz): delta 4.82 (s, 2H), 8.32-8.43 (m, 1H), 8.47-8.57 (m, 1H). m/z [MH+] 163/165/167 (100/60/10).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 89283-32-9, its application will become more common.

Reference of 89283-32-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows.

To (3-chloropyrazin-2-yl)methanol of step 1 was dropwise added a solution of SOCI2 (700mg, 5.89mmol) in DMF (10ml) at 0C. Stirring at 0C for 30 min was followed by extraction with ethyl acetate. The organic layer was washed with a saturated NaHC03 solution, dried over anhydrous magnesium sulfate, filtered, and concentrated in a vacuum. The residue was used in a subsequent step without further purification.

The chemical industry reduces the impact on the environment during synthesis (3-Chloropyrazin-2-yl)methanol. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Quality Control of (3-Chloropyrazin-2-yl)methanol

Under nitrogen protection,To a solution of 3-chloro-2-pyrazine methanol (60 g, 414.9 mmol)Triphenylphosphine (130.4 g, 497.9 mmol)And phthalimide (73.2 g, 497.9 mmol)Of the 500 mL THF solution,Was slowly added dropwise at -5 DIAD (100.6g, 497.9mmol),After complete addition, the reaction mixture was stirred at 20 3h,TLC shows that after completion of the reaction,Water was added to the reaction mixture and then extracted with EA (1 L x 3)The organic phase was dried sufficiently with anhydrous Na2SO4,After evaporation in vacuo, the residue was purified by flash chromatography (PE / EA = 30/1)To give 90.8 g of the title compound

The synthetic route of 89283-32-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chengdu Beite Pharmaceutical Co., Ltd.; Chengdu Hai Borui Pharmaceutical Co., Ltd.; Li Yingfu; Huang Haoxi; Liu Guanfeng; Chen Tonghun; Ren Junfeng; Su Zhonghai; (96 pag.)CN106831787; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (3-Chloropyrazin-2-yl)methanol

1.44 g of 3-chloro-2-pyrazine methanol, 2 mol% of vanadium nitrate (relative to the substrate 3-chloro-2-pyrazine methanol),Add to the 50mL reaction tube, Add 5mL of acetonitrile,Fill the air ball, close the reaction tube, and raise the temperature to 40 C with stirring.And kept for 10 h, until the reaction is over, and cooled to room temperature.Sampling was analyzed using gas chromatography.The conversion rate of 3-chloro-2-pyrazine methanol is 96.1%.The selectivity of 3-chloro-2-pyrazinecarboxaldehyde is greater than 99%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dalian University of Technology; Du Zhongtian; Tang Yangyang; Sun Xiaowan; Yue Jiajia; (6 pag.)CN106866508; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 89283-32-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89283-32-9, name is (3-Chloropyrazin-2-yl)methanol belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

(3-Chloropyrazin-2-yl)methanol (0.6 g, 4.15mmol, 1 eq.) was dissolved in 1,4-dioxane (16 mL) and water (5 mL). The solution and reaction vessel were purged with a stream of N2 gas. 1-isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.08 g, 4.57 mmol, 1.1 eq.), [1,1 ‘-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.3 g, 0.41 mmol, 0.1 eq.) and potassium carbonate (0.57 g, 4.15 mmol, 1 eq.) were added and the reaction was stirred in a heat block at 100 C. After 1 h, the reaction was judged to be complete by TLC (35% ethyl acetate/hexanes). The reaction mixture was cooled to 25 C, and taken up in a mixture of ethyl acetate (100 mL) and an aqueous saturated sodium bicarbonate solution (100 mL). The phases were separated and the aqueous phase was extracted once more with ethyl acetate (50 mL). The combined organic phases were washed with an aqueous saturated sodium chloride solution (50 mL) and dried over sodium sulfate. After filtration and evaporation, the residue was purified by silica gel chromatography (5 – 70% ethyl acetate/hexanes) to give (3-(l-isopropyl-lH-pyrazol-5- yl)pyrazin-2-yl)methanol (0.53 g, 59%) as a light yellow oil.

The synthetic route of (3-Chloropyrazin-2-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; LI, Zhe; HARRIS, Jason, R.; DUFU, Kobina, N.; GENG, Xin; SINHA, Uma; (101 pag.)WO2016/160755; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem