Category: 886860-50-0

Synthetic Route of 886860-50-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 886860-50-0, name is 2-Amino-5-iodopyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Step 1. methyl 3-(5-aminopyrazin-2-yl)propiolate To a 5 mL of microwave vial was added 5-iodopyrazin-2-amine (100 mg, 0.452 mmol), methyl propiolate (161 muL, 1.810 mmol), potassium carbonate (125 mg, 0.905 mmol), copper (I) iodide (3.45 mg, 0.018 mmol), and THF (1508 muL). The reaction mixture was heated at 65 C. for 2 h. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate, filtered, and evaporated in vacuo. The crude product was purified by flash chromatography (20% EtOAc in DCM) yielding methyl 3-(5-aminopyrazin-2-yl)propiolate (38%). LCMS (m/z): 178.4 (MH+), 0.48 min.

The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-iodopyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Novartis AG; Bagdanoff, Jeffrey T.; Ding, Yu; Han, Wooseok; Huang, Zilin; Jiang, Qun; Jin, Jeff Xianming; Kou, Xiang; Lee, Patrick; Lindvall, Mika; Min, Zhongcheng; Pan, Yue; Pecchi, Sabina; Pfister, Keith Bruce; Poon, Daniel; Rauniyar, Vivek; Wang, Xiaojing Michael; Zhang, Qiong; Zhou, Jianguang; Zhu, Shejin; (366 pag.)US9242996; (2016); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 886860-50-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 886860-50-0, name is 2-Amino-5-iodopyrazine, This compound has unique chemical properties. The synthetic route is as follows.

5-iodopyrazine-2-amine (18.4 g, 83.3 mmol), copper iodide (3.2 g, 16.7 mmol), 1.10-phenanthroline (6.6 g, 33.3 dissolved mmol) and sodium ethoxide (8.5 g,125 mmol) in ethanol (160 mL), 5 hours heated and stirred at 80 . After filtering off the unwanted materials, and concentrated under reducedpressure. The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 2: 1) as eluant to afford the title compound(2.51 g, 22%) as a white solid.

The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-iodopyrazine. I believe this compound will play a more active role in future production and life.