Category: 870787-06-7

Adding a certain compound to certain chemical reactions, such as: 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870787-06-7, Recommanded Product: 3-(Trifluoromethyl)pyrazine-2-carboxylic acid

PREPARATION EXAMPLE 7: 3-trifluoromethyl-pyrazine-2-carboxylic acid ri-(5-bromo-3-50 mg of C-[1 -(5-bromo-3-chloro-pyridin-2-yl)-cyclopropyl]-methylamine (step 1 of PREPARATION EXAMPLE 2) was dissolved in 0.9 ml of dichloromethane and 0.085 ml of triethylamine was added at ambient temperature. Then 383 mg of 3- (trifluoromethyl)pyridine-2-carboxylic acid, 54 mg of HOBT hydrate, 76 mg of EDCI.HCI and 37 mg of 3-trifluoromethyl-pyrazine-2-carboxylic acid were added sequentially. The reaction mixture was stirred at ambient temperature for 14 hours and then water was added, the phases were separated and the aqueous phase was extracted withdichloromethane. The organic phases were combined, dried with anhydrous sodium sulphate, filtered and concentrated. Crude material was obtained as a yellow sticky solid, which was purified by flash chromatography on silica gel with cyclohexane/ethyl acetate (1 :1 ) as a solvent. Thus, 76 mg of 3-trifluoromethyl-pyrazine-2-carboxylic acid [1 -(5-bromo- 3-chloro-pyridin-2-yl)-cyclopropylmethyl]-amide was obtained as a sticky solid. . 1H-NMR (CDCIs): 8.80 ppm (s, 1 H), 8.75 ppm (s, 1 H), 8.65 ppm (s, 1 H), 7.95 ppm (s, 1 H), 7.70 ppm (m, 1 H), 3.72 ppm (d, 2H), 1 .18 ppm (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; PITTERNA, Thomas; LOISELEUR, Olivier; WORTHINGTON, Paul, Anthony; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; BOBOSIK, Vladimir; WO2013/64521; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870787-06-7, Safety of 3-(Trifluoromethyl)pyrazine-2-carboxylic acid

Diphenylphosphoryl azide (3.47g, 12.6mmol) was added to a stirred solution of 3- trifluoromethylpyrazine-2-carboxylic acid (1 .92g, 9.7Ommol) and triethylamine (1 .28g, 12.6mmol) in tert-butanol (9.6m1, lOOmmol) and toluene (19.2m1). The resulting mixturewas heated at 90C for 4 hours and then allowed to cool. It was washed with 2M aqueous sodium bicarbonate, then dried through a phase-separation filter and concentrated under reduced pressure. The residue was purified by chromatography on silica gel using a gradient of ethyl acetate in hexane as eluent to give tert-butyl N-(3-trifluoromethylpyrazin- 2-yl)-carbamate containing 3-trifluoromethyl-2-aminopyrazine (2.Og) as a colourless oilwhich slowly crystallised to give a white solid. 1H NMR (400 MHz, CDCl3) 8.70 (s, 1H),8.40 (s, 1H), 7.20 (brs, 1H), 1.55 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (48 pag.)WO2019/57724; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 870787-06-7,Some common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, molecular formula is C6H3F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 100 mL round bottom flask was charged with the compound represented by the formula (II-1) (2 mmol), EDCI (2.4 mmol), HOBt (2.4 mmol) and 10 mL of DMF, and reacted at 25 C. for 1 h. Then, the compound (2.4 mmol) represented by the formula (II-2) was added to the above solution and reacted at 25C for 24 hours. After the solvent was removed, the target product was obtained by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its application will become more common.

Reference:
Patent; Central China Normal University; Yang Guangfu; Li Hua; Xiong Li; (34 pag.)CN108069915; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 870787-06-7,Some common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, molecular formula is C6H3F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A compound (2 mmol) represented by the formula (2-1) was added to a 100 mL round bottom flask.EDCI (2.4 mmol), HOBt (2.4 mmol) and 10 mL of DMF were reacted at 25 C for 1 h.Then, the compound represented by formula (2-21) or formula (2-22)(2.4 mmol) was added to the above solution,Reaction at 25 C for 24 h,After removing the solvent, column chromatography gave the desired product (yield of the desired product as a one-step yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its application will become more common.

Reference:
Patent; Central China Normal University; Yang Guangfu; Li Hua; Xiong Li; (10 pag.)CN109666004; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 870787-06-7

N- [2- (3,5- dichloro-pyridin-2-yl) -2- (tert- Butokishiimino) ethyl] -3-(trifluoromethyl) pyrazine-2-carboxamide 3- (tri N in dichloromethane 3ml solution of fluoromethyl) pyrazine-2-carboxylic acid 74mg, added N- dimethylformamide 10mg and oxalyl chloride 57mg, I was stirred at room temperature for 1 hour.After completion of the reaction, distilling off the solvent under reduced pressure, the residue was dissolved in dichloromethane 10ml, stirring under ice cooling, 2-amino-1- (3,5-dichloro-2-yl) ethanone -O- ( was added tert- butyl) oxime and triethylamine 89mg 39mg, it was continued for a further 1 hour stirring at room temperature.After completion of the reaction, extracted with added water 10ml reaction mixture chloroform (10mlx1), and the organic layer brine then dehydrated and dried in this order over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.The residue was ethyl acetate – hexane (1: 9 to 3: 7 gradient) was purified by silica gel column chromatography eluting with a respective geometric isomers 22mg (isomer A) of the object and 111mg (isomers The B) it was obtained as a colorless resin-like substance

The synthetic route of 3-(Trifluoromethyl)pyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES LIMITED; Iwasa, Motoyoshi; Tomizawa, Mitsutaka; Tsuji, Keisuke; Nakamura, Toshiyuki; Mita, Takeshi; Kuwahara, Hidehito; asahi, Miho; Imanaka, Hotaka; (342 pag.)JP2016/11286; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 870787-06-7, These common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Diphenylphosphoryl azide (3.47g, 12.6mmol) was added to a stirred solution of 3- trifluoromethylpyrazine-2-carboxylic acid (1.92g, 9.70mmol) and triethylamine (1 .28g, 12.6mmol) in tert-butanol (9.6ml, l OOmmol) and toluene (19.2ml). The resulting mixture was heated at 90C for 4 hours and then allowed to cool. It was washed with 2M aqueous sodium bicarbonate, then dried through a phase-separation filter and concentrated under reduced pressure. The residue was purified by chromatography on silica gel using a gradient of ethyl acetate in isohexane as eluent to give tert-butyl N-(3- trifluoromethylpyrazin-2-yl)-carbamate (2.0g) as a colourless oil which slowly crystallised to give a white solid. (0268) 1H NMR (400MHz, CDCI3) delta 8.65 (d, 1 H), 8.40 (d, 1 H), 7.15 (br s, 1 H), 1 .55 (s, 9H).

Statistics shows that 3-(Trifluoromethyl)pyrazine-2-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 870787-06-7.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WAILES, Jeffrey, Steven; CARTER, Neil, Brian; CLOUGH, John, Martin; WILLIAMS, John; (57 pag.)WO2019/57723; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-(Trifluoromethyl)pyrazine-2-carboxylic acid

Example 2. Production of N-[2-(2,4-dichlorophenyl)-1-methylethyl]-2-trifluoromethylpyrazine-3-carboxamide (compound No. 3-43) To a solution of 2-trifluoromethylpyrazine-3-carboxylic acid (0.25 g, 1.3 mmol), [2-(2,4-dichlorophenyl)-1-methylethyl]amine (0.27 g, 1.3 mmol) and 4-dimethylaminopyridine (0.19 g, 1.6 mmol) in chloroform (10 ml) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.3 g, 1.6 mmol) and the mixture was stirred at room temperature for 12 hrs. After adding water and chloroform, the mixture was partitioned, and the organic layer was washed successively with water and saturated brine and dried over anhydrous sodium sulfate. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give a desired compound (yield; 0.31 g, 63%). property; melting point 163-164C

The synthetic route of 870787-06-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NIHON NOHYAKU CO., LTD.; EP1997800; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870787-06-7, Recommanded Product: 870787-06-7

Diphenylphosphoryl azide (3.47g, 12.6mmol) was added to a stirred solution of 3- trifluoromethylpyrazine-2-carboxylic acid (1 .92g, 9.7Ommol) and triethylamine (1 .28g, 12.6mmol) in tert-butanol (9.6m1, lOOmmol) and toluene (19.2m1). The resulting mixturewas heated at 90C for 4 hours and then allowed to cool. It was washed with 2M aqueous sodium bicarbonate, then dried through a phase-separation filter and concentrated under reduced pressure. The residue was purified by chromatography on silica gel using a gradient of ethyl acetate in hexane as eluent to give tert-butyl N-(3-trifluoromethylpyrazin- 2-yl)-carbamate containing 3-trifluoromethyl-2-aminopyrazine (2.Og) as a colourless oilwhich slowly crystallised to give a white solid. 1H NMR (400 MHz, CDCl3) 8.70 (s, 1H),8.40 (s, 1H), 7.20 (brs, 1H), 1.55 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Some common heterocyclic compound, 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, molecular formula is C6H3F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(Trifluoromethyl)pyrazine-2-carboxylic acid

To 74 mg of 3-(trifluoromethyl)pyrazine-2-carboxylic acid in 3 ml of dichloromethane, 10 mg of N,N-dimethylformamide and 57 mg of oxalyl chloride were added, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was evaporated under reduced pressure, and the resulting residue was dissolved in 10 ml of dichloromethane. To the solution, 89 mg of 2-amino-1-(3,5-dichloropyridin-2-yl)ethanone-O-(tert-butyl)oxime and 39 mg of triethylamine were added with stirring under cooling with ice, and the mixture was stirred at room temperature for another 1 hour. After completion of the reaction, the reaction mixture was mixed with 10 ml of water and extracted with chloroform (10 ml*1), the resulting organic layer was dried over saturated aqueous sodium chloride and then anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 1:9 to 3:7) as the eluent to obtain 22 mg of geometrical isomer A and 111 mg of geometrical isomer B of the desired product as colorless resinous substances.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 870787-06-7, its application will become more common.

Reference:
Patent; Nissan Chemical Industries, Ltd.; IWASA, Motoyoshi; TSUJI, Keisuke; TOMIZAWA, Mitsutaka; MITA, Takeshi; KUWAHARA, Hidehito; ASAHI, Miho; IMANAKA, Hotaka; EP2873658; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 870787-06-7, name is 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870787-06-7, Recommanded Product: 870787-06-7

PREPARATION EXAMPLE 7: 3-trifluoromethyl-pyrazine-2-carboxylic acid ri-(5-bromo-3-50 mg of C-[1 -(5-bromo-3-chloro-pyridin-2-yl)-cyclopropyl]-methylamine (step 1 of PREPARATION EXAMPLE 2) was dissolved in 0.9 ml of dichloromethane and 0.085 ml of triethylamine was added at ambient temperature. Then 383 mg of 3- (trifluoromethyl)pyridine-2-carboxylic acid, 54 mg of HOBT hydrate, 76 mg of EDCI.HCI and 37 mg of 3-trifluoromethyl-pyrazine-2-carboxylic acid were added sequentially. The reaction mixture was stirred at ambient temperature for 14 hours and then water was added, the phases were separated and the aqueous phase was extracted withdichloromethane. The organic phases were combined, dried with anhydrous sodium sulphate, filtered and concentrated. Crude material was obtained as a yellow sticky solid, which was purified by flash chromatography on silica gel with cyclohexane/ethyl acetate (1 :1 ) as a solvent. Thus, 76 mg of 3-trifluoromethyl-pyrazine-2-carboxylic acid [1 -(5-bromo- 3-chloro-pyridin-2-yl)-cyclopropylmethyl]-amide was obtained as a sticky solid. . 1H-NMR (CDCIs): 8.80 ppm (s, 1 H), 8.75 ppm (s, 1 H), 8.65 ppm (s, 1 H), 7.95 ppm (s, 1 H), 7.70 ppm (m, 1 H), 3.72 ppm (d, 2H), 1 .18 ppm (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)pyrazine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SYNGENTA LIMITED; PITTERNA, Thomas; LOISELEUR, Olivier; WORTHINGTON, Paul, Anthony; O’SULLIVAN, Anthony, Cornelius; LUKSCH, Torsten; BOBOSIK, Vladimir; WO2013/64521; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem