Category: 78109-26-9

Li, Yanyang’s team published research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 78109-26-9

1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Recommanded Product: 78109-26-9

Li, Yanyang; Zhou, Yan; Qian, Pengyu; Wang, Yongzhen; Jiang, Falong; Yao, Zhenglin; Hu, Wenxiang; Zhao, Yanjin; Li, Shuxin published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis and bioevaluation of novel benzamide derivatives as HDAC inhibitors》.Recommanded Product: 78109-26-9 The author mentioned the following in the article:

A series of novel benzamide derivatives was designed and synthesized as HDAC inhibitors. Exploration of the structure-activity relationships resulted in compounds that are potent in vitro. In addition, the best compound exhibited an acceptable pharmacokinetic profile with bioavailability in rat of 81% and could be considered as a candidate compound for further development. The results came from multiple reactions, including the reaction of 1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9Recommanded Product: 78109-26-9)

1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Recommanded Product: 78109-26-9

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Lumma, William C. Jr.’s team published research in Journal of Organic Chemistry in 1981 | CAS: 78109-26-9

1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Formula: C8H7N3O

《Novel condensation of 2,3-epoxybutanal with 2-aminopyridine and 2-aminopyrazine. Synthesis and stability of 3-(1-hydroxyethyl)imidazo[1,2-a]azines》 was written by Lumma, William C. Jr.; Springer, James P.. Formula: C8H7N3O And the article was included in Journal of Organic Chemistry on August 28 ,1981. The article conveys some information:

The title condensations gave azines I (X = CH, N) in 53 and 26% yield, resp. I (X = N) was oxidized to give 81% ketone II. I were not easily accessible by functionalization of the parent heterocycles due to facile decomposition of the latter. The crystal structure of II was determined After reading the article, we found that the author used 1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9Formula: C8H7N3O)

1-(Imidazo[1,2-a]pyrazin-3-yl)ethanone(cas: 78109-26-9) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Formula: C8H7N3O

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem