Category: 75907-74-3

These common heterocyclic compound, 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 75907-74-3

The obtained 2-hydroxymethyl-3,5,6-trimethylpyrazine (152 mg, 1 mmol) was dissolved in a THF solution, and phosphorus tribromide (410 mg, 1.5 mmol) was added dropwise under an ice bath condition. The reaction was stirred at 0 C for 30 minutes, and the reaction was quenched by adding saturated sodium bicarbonate. Dilute with 50ml of ethyl acetate, and wash the organic layer three times with saturated brine, dry over anhydrous sodium sulfate, filter, and concentrate, silica gel column chromatography (petroleum ether: ethyl acetate = 2: 1)2-bromomethyl-3,5,6-trimethylpyrazine was obtained as a light yellow solid (182 mg, 85%).

The synthetic route of (3,5,6-Trimethylpyrazin-2-yl)methanol has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Taizhou College; Mu Yi; Zhang Rui; Liu Jing; Gao Xinxing; (8 pag.)CN110483419; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 75907-74-3,Some common heterocyclic compound, 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, molecular formula is C8H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(4) In a round bottom flask, add (4) (1.0 equiv), add DCM as solvent, add phosphorus tribromide (1.0-2.0 equiv) at 0 C, stir the reaction at 25 C for 1 h, TLC monitoring The formula (4) disappears, and after completion of the reaction, water is added, and dichloromethane is extracted, and the organic layer is collected, dried and concentrated to give a compound of the formula (5) as a white solid.

The synthetic route of 75907-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chengdu University; Zou Liang; Zhang Jinming; Liu Xiaowei; Li Wei; Li Hanmei; Zhang Yan; Zhang Lele; Yang Yong; (14 pag.)CN110101872; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 75907-74-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 75907-74-3 name is (3,5,6-Trimethylpyrazin-2-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Weigh 2-hydroxymethyl-3,5,6-trimethylpyrazine (3.0 g, 25 mmol),Dissolved in 50mL of absolute ethanol,Manganese dioxide powder (4.34 g, 50 mmol) was added with stirring.The reaction was carried out under heating and reflux for 6 h.Cooling the reaction solution,Add diatomaceous earth and filter under reduced pressure.After the filter cake is rinsed with ethanol,Merged with the filtrate,Evaporation of the solvent gave a pale yellow solid.Is a crude product of 3,5,6-trimethylpyrazine-2-formaldehyde,Then perform rapid column chromatography separation,Light yellow solid,That is pure 3,5,6-trimethylpyrazine-2-carboxaldehyde,Yield 90%,Melting point 84-85 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3,5,6-Trimethylpyrazin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Shandong University; Liu Xinyong; Zou Jinmi; Zhan Peng; (14 pag.)CN108484511; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H12N2O

Were added 2-hydroxymethyl-3,5,6-trimethyl pyrazine in 250mL three-necked flask (9.5g, 62.5mmol), MnO2(16.2g, 187.5mmol), ethanol 100mL, refluxed for 12h, TLC (petroleum ether – ethyl acetate 2: 1) detecting the reaction is substantially complete, cooled, filtered, recovering ethanol under reduced pressure to give a yellow solid by silica gel column chromatography (petroleum ether – ethyl acetate 4: 1) to give 8.8 g of a pale yellow solid, yield 93.9%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Anhui University of Chinese Medicine; Hefei Medical Engineering Pharmaceutical Co., Ltd.; Hefei Enruite Pharmaceutical Co., Ltd.; Li Jiaming; He Guangwei; Zhang Yang; Huang Weijun; Zhang Yanchun; Liu Weizhong; Zuo Jian; Liu Huicai; Zhu Panhu; Wang Yujun; (14 pag.)CN106518791; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 75907-74-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In the reaction flask, 2-hydroxymethyl-3,5,6-trimethylpyrazine (3 g, 0.02 mol) was added, Dissolved in 20 mL of dichloromethane, The ice bath was added dropwise with stirring Thionyl chloride (3 mL, 0.04 mol), Stirring reaction 1.5h TLC monitoring to the reaction is complete, The solvent and the remaining dichlorosulfoxide were evaporated under reduced pressure to give a pale yellow mass 2-chloromethyl-3,5,6-trimethylpyrazine 3.2 g, 20 mL of DMF (N, N-dimethylformamide) was added.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3,5,6-Trimethylpyrazin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KPC Pharmaceuticals, Inc; song, LI MING; Bai, Fei; Yang, ZHAO XIANG; (15 pag.)CN104341358; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem