Category: 75907-74-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 75907-74-3

General procedure: To a solution of A1B1 (1.0mmol) and triphenylphosphine (1.5mmol) in anhydrous tetrahydrofuran (3mL), added C1 or C2 (2.0mmol) and dropwise added diethyl azodicarboxylate (DEAD, 1.5mmol) in anhydrous and anoxybiotic conditions. The reaction mixture was stirred at-2C for 30min, and then stirred at room temperature for 24h. After completion of reaction was monitored through TLC, the reaction mixture was filtered and washed with ether and saturated salt water to get products because there would be a solid precipitate.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75907-74-3.

Reference:
Article; Wang, Fang; Sun, Jun-Rong; Huang, Mei-Yan; Wang, Hui-Ying; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min; European Journal of Medicinal Chemistry; vol. 72; (2014); p. 35 – 45;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 75907-74-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Weigh 2-hydroxymethyl-3,5,6-trimethylpyrazine (3.0 g, 25 mmol),Dissolved in 50mL of absolute ethanol,Manganese dioxide powder (4.34 g, 50 mmol) was added with stirring.The reaction was carried out under heating and reflux for 6 h.Cooling the reaction solution,Add diatomaceous earth and filter under reduced pressure.After the filter cake is rinsed with ethanol,Merged with the filtrate,Evaporation of the solvent gave a pale yellow solid.Is a crude product of 3,5,6-trimethylpyrazine-2-formaldehyde,Then perform rapid column chromatography separation,Light yellow solid,That is pure 3,5,6-trimethylpyrazine-2-carboxaldehyde,Yield 90%,Melting point 84-85 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3,5,6-Trimethylpyrazin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong University; Liu Xinyong; Zou Jinmi; Zhan Peng; (14 pag.)CN108484511; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75907-74-3, name: (3,5,6-Trimethylpyrazin-2-yl)methanol

To a solution of (3,5,6-trimethylpyrazin-2-yl)methanol(4) (15.50 g, 102 mmol) in anhydrous CH2Cl2 (300 mL),thionyl chloride (7.41 mL, 102 mmol) was added drop bydrop at 0 C. After finishing dropping, the mixture wasstirred at room temperature for 2.5 h. The solvent was evaporatedin vacuo and the product 2-chloromethyl-3,5,6-trimethylpyrazine hydrochloride (5) was obtained as yellowsolid (21.11 g, 100%), mp: 102-105 C [11].

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Reference:
Article; Li, Zhenyu; Yu, Fang; Cui, Lei; Chen, Wenmin; Wang, Shouxun; Zhan, Peng; Shen, Yuemao; Liu, Xinyong; Medicinal Chemistry; vol. 10; 1; (2014); p. 81 – 89;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75907-74-3, Product Details of 75907-74-3

To a stirred, cooled (0C) solution of (3,5,6-trimethylpyrazin-2-yl)methanol (0.3 g, 1.97 mmol) in dichloromethane (5 ml) under an argon atmosphere was added dropwise a solution of thionyl chloride (469 mg, 286 mu, 3.94 mmol) in 2 ml CH2CI2. When the addition was complete, the ice bath was removed and stirring at r.t. was continued for 2 hrs. The mixture was concentrated to dryness to leave the crude product as a light red solid (417 mg) which was used in the next step without further purification. MS: M = 171.1 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3,5,6-Trimethylpyrazin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; LERNER, Christian; WO2013/178569; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H12N2O

Reaction step 2-hydroxymethyl-3,5,6-trimethylpyrazine (9.5 g, 62.5 mmol) was sequentially added to a 250 mL three-necked flask,MnO2 (16.2 g, 187.5 mmol),Ethanol 100mL,Reflux 12h,TLC (petroleum ether – ethyl acetate 2: 1) detection reaction is almost complete,cool down,Filtering to obtain filtrate,Ethanol recovery under reduced pressure,To give a yellow solid,Purification by silica gel column chromatography (petroleum ether-ethyl acetate 4: 1)3,5,6-trimethylpyrazine-2-carbaldehyde as a pale yellow solid,The yield was 93.9%

The synthetic route of 75907-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anhui University of Chinese Medicine; Li, Jiaming; He, Guangwei; Chu, Zhaoxing; Huang, Weijun; Zhang, Yanchun; Xie, Di; Zuo, Jian; Liu, Huicai; (11 pag.)CN105237487; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 75907-74-3, These common heterocyclic compound, 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step (1): to a 50 ml three-necked flask, the QR01006-IN-01 (500 mg, 3.29 mmol), dichloromethane (10 mL), chloromethyl chloroformate (460 mg, 3.6 mmol) were added. The resultant mixture solution was controlled at the temperature of -2 C., and then pyridine (0.32 mL) was dropwise added while controlling the temperature of no greater than 3 C. After the dropwise addition, the reaction solution was heated to room temperature and stirred overnight. The TLC (petroleum ether/ethyl acetate=1:3) was used to monitor the reaction until the raw materials were fully reacted. The reaction solution was filtered, and the resulting filtrate was dried by rotary evaporation, to give 1.1 g of yellow oil. The yellow oil was purified by preparative plate to give 620 mg of yellow liquid, with the yield of 77.3%. LCMS and HNMR spectra can confirm the structure of the target compound.

Statistics shows that (3,5,6-Trimethylpyrazin-2-yl)methanol is playing an increasingly important role. we look forward to future research findings about 75907-74-3.

Reference:
Patent; WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD; WUHAN QR PHARMACEUTICALS CO., LTD; GE, Jian; MA, Jianyi; XIANG, Guangya; WANG, Wei; WANG, Chaodong; (46 pag.)US2017/22188; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H12N2O

The obtained 7.5 g of TMP-OH (49.3 mmol) was dissolved in 50 ml of absolute ethanol to add active manganese dioxide.(6.4g, 73.6mmol) was oxidized and reacted in an oil bath at 84 C for 2 h. After the TLC reaction was completed,The reaction solution was carefully filtered with a five-layer filter paper while hot, and the manganese dioxide powder was removed.After filtration, a clear filtrate was obtained, which was evaporated to dryness under reduced pressure on a rotary evaporator. Wet loading column chromatography:The mobile phase EA:PE (1:5) was separated and purified, and the fraction was monitored by TLC. Collecting the compound 1a-4 fraction,Combine the same fraction and distill it to obtain a crystalline white solid.5.5g (36.7mmol),[M+H]+=151 is 1a-4 (TMP-CHO), yield 75%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 75907-74-3.

Reference:
Patent; Guangzhou Xique Pharmaceutical Co., Ltd.; Wang Yuqiang; Yao Hui; Wu Chuanbin; Tao Liang; Sun Yewei; (27 pag.)CN103804309; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Recommanded Product: (3,5,6-Trimethylpyrazin-2-yl)methanol

In a 50 ml round-bottom flask the compound TMP-OH (1.52 g 10 mmol) was added and dissolved in 20 mL of anhydrous ethanol active manganese dioxide (2.61 g 30 mmol) was added heated to reflux for 3 hours and monitored by TLC until the starting material completely comsumed and the resulting material was filtered and concentrated and separated with column chromatography eluted with ethyl acetate /petroleum ether (11) to give the compound TMP-CHO as a white solid (0.99 g 66) .

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GUANGZHOU MAGPIE PHARMACEUTICAL CO., LTD; WANG, Yuqiang; YOUDIM, Moussa B.H.; SUN, Yewei; ZHANG, Zaizun; ZHANG, Gaoxiao; YU, Pei; YI, Peng; LIANG, Ming; LIU, Wei; WO2015/109935; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 75907-74-3, These common heterocyclic compound, 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1a (6.08 g, 40 mmol) was dissolved in CHCl3 (60 mL),MnO2 (24 g, 280 mmol) was added, and the mixture was refluxed for 6 h, cooled, filtered, and concentrated. The crude productwas purified by column chromatography and eluted with ethyl acetate-petroleum ether (1:6) to yield 1b as bright yellowcrystals (4.2 g, 70%), mp 86C. ESI-MS m/z 151 [M + 1]+, C8H10N2O. 1H NMR (500 MHz, CDCl3, , ppm): 10.10 (1H, s,CHO), 2.75 (3H, s, CH3), 2.56 (6H, s, CH3 2). 13C NMR (125 MHz, CDCl3, , ppm): 21.39, 22.18, 141.91, 149.98, 151.54,155.45, 194.33.

Statistics shows that (3,5,6-Trimethylpyrazin-2-yl)methanol is playing an increasingly important role. we look forward to future research findings about 75907-74-3.

Reference:
Article; Zhang, Chao; Chen, Lang-Di; Liang, Xin-Tong; Liu, Wei-Xiong; Wu, Wen-Hao; Chemistry of Natural Compounds; vol. 53; 1; (2017); p. 114 – 117; Khim. Prir. Soedin.; vol. 53; 1; (2017); p. 96 – 98,3;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 75907-74-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 50 ml round-bottom flask the compound TMP-OH (1.52 g 10 mmol) was added and dissolved in 20 mL of anhydrous ethanol active manganese dioxide (2.61 g 30 mmol) was added heated to reflux for 3 hours and monitored by TLC until the starting material completely comsumed and the resulting material was filtered and concentrated and separated with column chromatography eluted with ethyl acetate /petroleum ether (11) to give the compound TMP-CHO as a white solid (0.99 g 66) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3,5,6-Trimethylpyrazin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GUANGZHOU MAGPIE PHARMACEUTICAL CO., LTD; WANG, Yuqiang; YOUDIM, Moussa B.H.; SUN, Yewei; ZHANG, Zaizun; ZHANG, Gaoxiao; YU, Pei; YI, Peng; LIANG, Ming; LIU, Wei; WO2015/109935; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem