Category: 73627-18-6

Adding a certain compound to certain chemical reactions, such as: 73627-18-6, name is 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73627-18-6, HPLC of Formula: C8H12N2

Synthesis of 4-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanoic acid S4 A solution of (190 mg, 1.4 mmol) of 1-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (A21) in THF (10 ml) was added dropwise in the course of 30 min to a suspension of (558 mg, 5.6 mmol) of succinic anhydride in THF (10 ml). The mixture was then stirred for 2 h at RT and concentrated in vacuo. The residue was taken up in chloroform, washed with water and brine, dried over MgSO4 and concentrated in vacuo. 257 mg (0.92 mmol, 54%) of 4-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-4-oxobutanoic acid (S4) were obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine, and friends who are interested can also refer to it.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 73627-18-6 as follows. Product Details of 73627-18-6

Example 1 (6-chloro-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-3,4-dihydro-1H-pyrrolo[ 1,2-a]pyrazin-2-yl)-methanone A solution of 6-chloro-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (181 mg, 0.92 mmol, 1.0 equiv), 1-methyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine (150 mg, 1.10 mmol, 1.2 equiv), EDC (176 mg, 0.92 mmol, 1.0 equiv) and HOAt (125 mg, 0.92 mmol, 1.0 equiv) in DMF (5 mL) was heated at 50C for 4 h. The mixture was allowed to cool to room temperature and poured into water and extracted with ethyl acetate. The combined organic layers were washed three times with brine, dried over Na2SO4 and concentrated. The residue was subjected to flash column chromatography (40% ethyl acetate in heptane) to yield 265 mg (91 %) of the title compound in good to moderate yield. LC/MS: m/z = 317 (MH+)

According to the analysis of related databases, 73627-18-6, the application of this compound in the production field has become more and more popular.