Adding a certain compound to certain chemical reactions, such as: 717847-03-5, name is 6-Morpholinopyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 717847-03-5, Safety of 6-Morpholinopyrazin-2-amine
5,7-Difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2- yl)quinolin-4-amineThe Buchwald coupled product was prepared according to Procedure H using of dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (0.025 g, 0.053 mmol), 6-morpholinopyrazin-2-amine (0.071 g, 0.39 mmol), 4-chloro-5,7-difluoro-3- methyl-2-(4-methylpyridin-2-yl)quinoline (0.1 g, 0.33 mmol) and Pd2dba3 (0.012 g, 0.013 mmol) and sodium tert-butoxide (0.079 g, 0.82 mmol) in toluene (3.3 mL) at 100 C for 48.5 h. The crude product was purified by columnchromatography on alumina (0 to 60% EtOAc in hexanes) to yield the desired product 5,7-difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2-yl)quinolin-4-amine. .H NMR (400 MHz, CD2C12) delta ppm 8.55 (1 H, d, J=5.1 Hz), 7.64 – 7.67 (1 H, m), 7.59 (1 H, s), 7.54 (1 H, ddd, J=9.6, 2.5, 1.4 Hz), 7.38 (1 H, s), 7.17 – 7.26 (2 H, m), 7.02 (1 H, ddd, J=13.3, 8.8, 2.5 Hz), 3.69 – 3.76 (4 H, m), 3.39 – 3.46 (4 H, m), 2.47 (3 H, s), 2.26 (3 H, s). Mass Spectrum (ESI) m/e = 449.1 (M + 1).
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