Category: 6924-68-1

Alvarez-Ibarra, C. et al. published their research in Journal of Organic Chemistry in 1994 | CAS: 6924-68-1

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Synthetic Route of C7H8N2O2

Synthesis, Configurational Assignment and Conformational Analysis of β-Hydroxy Sulfoxides, Bioisosteres of Oxisuran Metabolites, and their O-Methyl Derivatives was written by Alvarez-Ibarra, C.;Cuervo-Rodriguez, R.;Fernandez-Monreal, M. C.;Ruiz, M. P.. And the article was included in Journal of Organic Chemistry in 1994.Synthetic Route of C7H8N2O2 This article mentions the following:

Synthesis, configurational assignment, and conformational anal. of diastereoisomers of 2-(methylsulfinyl)-1-(2-quinolyl)ethanol, 2-(methylsulfinyl)-1-(1-isoquinolyl)ethanol, 2-(methylsulfinyl)-1-(2-pyrazinyl)ethanol, and their O-Me derivatives are reported. The configurational assignment and conformational anal. of the two diastereoisomers of β-hydroxy sulfoxides and β-methoxy sulfoxides have been carried out from the observed vicinal coupling constants using the mol. mechanics force field (MMX) and the Altona relationship as fundamental tools. The conformational equilibrium is explained in terms of polar and steric factors. Of significant importance was the role of intramol. hydrogen bonding in the RS/SR isomers of β-hydroxy sulfoxides. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Synthetic Route of C7H8N2O2).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine has the elements of symmetry for the point group D2h. It has three mutually perpendicular two-fold axes. It also has three mutually perpendicular planes of symmetry. As a result, pyrazine also has a centre of symmetry. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.Synthetic Route of C7H8N2O2

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Heinisch, Gottfried et al. published their research in Angewandte Chemie in 1985 | CAS: 6924-68-1

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Safety of Ethyl pyrazine-2-carboxylate

Decisive increase of regioselectivity in radical substitutions: Minisci reaction in the two-phase system was written by Heinisch, Gottfried;Loetsch, Gerhard;Vieboeck, Franz. And the article was included in Angewandte Chemie in 1985.Safety of Ethyl pyrazine-2-carboxylate This article mentions the following:

The ethoxycarbonylation of isonicotinonitrile by EtO2C• (formed from Et pyruvate, H2O2, FeSO4, and H2SO4 in H2O) gave I along with other mono- and disubstitution products. Addition of CH2Cl2 increased the yield of I appreciably. Similar results were obtained with nicotinonitrile and pyrazine. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Safety of Ethyl pyrazine-2-carboxylate).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Safety of Ethyl pyrazine-2-carboxylate

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Rao, G. Venkoba et al. published their research in Indian Journal of Chemistry in 1975 | CAS: 6924-68-1

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.HPLC of Formula: 6924-68-1

Solvent effects on NMR. Differential shifts of ring protons of heterocyclics in dimethyl sulfoxide was written by Rao, G. Venkoba;Balakrishnan, M.;Venkatasubramanian, N.. And the article was included in Indian Journal of Chemistry in 1975.HPLC of Formula: 6924-68-1 This article mentions the following:

The NMR spectra of pyrazine, pyridine, triazine, pyrrole, imidazole, Et furan-2-carboxylate, Me 4-pyridylacetate, and Et pyrazinecarboxylate are examined in (D3C)2SO. The differential shifts of ring protons are accounted for in terms of an interaction between the lone pair on the ring hetero atom and the pos. end of the sulfoxide dipole in the solvent. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1HPLC of Formula: 6924-68-1).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine heterocycles and their benzo derivatives possess many interesting properties, including chemical reactivity profiles, and have diverse applications in total synthesis, medicine, chemical biology, materials, dyes, and imaging. Pyrazines undergo nearly all of the same reactions as pyrimidines, from nucleophilic substitution (SNAr) to palladium-catalyzed cross coupling reactions.HPLC of Formula: 6924-68-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Sorensen, Ulrik S. et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2001 | CAS: 6924-68-1

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 6924-68-1

Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology was written by Sorensen, Ulrik S.;Falch, Erik;Stensbol, Tine B.;Jaroszewski, Jerzy W.;Madsen, Ulf;Krogsgaard-Larsen, Povl. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2001.Reference of 6924-68-1 This article mentions the following:

We have previously reported the synthesis and pharmacol. characterization of analogs of 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) in which the Me group was replaced by a Ph group (APPA) or heteroaryl groups. While 2-amino-3-[3-hydroxy-5-(2-furyl)-4-isoxazolyl]propionic acid and its 3-pyridyl analog 2-amino-3-[3-hydroxy-5-(3-pyridyl)-4-isoxazolyl]propionic acid (3-Py-AMPA) show very low affinity for AMPA receptors, introduction of heteroaryl substituents containing heteroatom in the 2-position provides potent AMPA receptor agonists. We here report the synthesis and pharmacol. of 2-amino-3-(3-hydroxy-5-pyrazinyl-4-isoxazolyl)propionic acid (IC50 = 1.2 μM; EC50 = 11 μM), which is weaker as an AMPA agonist than AMPA (IC50 = 0.040 μM; EC50 = 3.5 μM) but comparable in potency with 2-amino-3-[3-hydroxy-5-(2-pyridyl)-4-isoxazolyl]propionic acid (IC50 = 0.57 μM; EC50 = 7.4 μM), as determined in radioligand binding and electrophysiol. experiments, resp. The AMPA analogs containing 2-, 3-, or 4-methoxyphenyl substituents, resp., and the corresponding hydroxyphenyl analogs were also synthesized and evaluated pharmacol. With the exception of 2-amino-3-[3-hydroxy-5-(2-hydroxyphenyl)-4-isoxazolyl]propionic acid, which is a very weak AMPA agonist (IC50 = 45 μM; EC50 = 324 μM), none of these compounds showed detectable effect at AMPA receptors. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1Reference of 6924-68-1).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazine is a symmetrical molecule with point group D2h. Pyrazine is less basic than pyridine, pyridazine and pyrimidine. Pyrazine and a variety of alkylpyrazines are flavor and aroma compounds found in baked and roasted goods. Tetramethylpyrazine (also known as ligustrazine) is reported to scavenge superoxide anion and decrease nitric oxide production in human Granulocytes.Reference of 6924-68-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Yamagami, Chisako et al. published their research in Journal of Pharmaceutical Sciences in 1993 | CAS: 6924-68-1

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.SDS of cas: 6924-68-1

Hydrophobicity parameter of diazines. III. Relationship of partition coefficients of monosubstituted diazines and pyridines in different partitioning systems was written by Yamagami, Chisako;Takao, Narao;Fujita, Toshio. And the article was included in Journal of Pharmaceutical Sciences in 1993.SDS of cas: 6924-68-1 This article mentions the following:

The logarithm of the 1-octanol-water partition coefficient value (log Poct) was compared with those from CHCl3-water (log PCL) and di-n-Bu ether-water (log PE) for (di)azines substituted singly by nonhydrogen-bonding and hydrogen-accepting substituents (2-substituted pyrazines, 2-substituted pyrimidines, and 2-substituted pyridines). The difference between log Poct and log PCL for diazines was primarily governed by the number of hydrogen-bonding sites in the substituent. For 2-substituted pyridines, the difference in the hydrogen-bonding association of the ring N-atom with octanol from that with CHCl3 was also significant. In the relationship between log Poct and log PE, the hydrogen-bonding solvations of the ring N-atom(s), as well as the hydrogen-accepting substituent with octanol, should be taken into account because the Bu ether acts as a nonhydrogen-bonding solvent. In the experiment, the researchers used many compounds, for example, Ethyl pyrazine-2-carboxylate (cas: 6924-68-1SDS of cas: 6924-68-1).

Ethyl pyrazine-2-carboxylate (cas: 6924-68-1) belongs to pyrazine derivatives. Pyrazines are part of several biologically active polycyclic compounds; examples are quinoxalines, phenazines; and the bio-luminescent natural products pteridines, flavins, and their derivatives. Substituted pyrazines have been found as subunits of multiple synthetically constructed therapeutic agents, as well as several natural products.SDS of cas: 6924-68-1

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Brief introduction of 6924-68-1

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 6924-68-1, name is Ethyl pyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6924-68-1, Formula: C7H8N2O2

Ethyl pyrazine carboxylate (4.0 g, 13.14 mmol) in 200 mL of DCM was treated at O0C with meta-chloroperbenzoic acid (57- 80%, 5.67 g). The mixture was allowed to warm to ambient temperature and stirred for 72 h, when an additional 4.28 g of meta-chloroperbenzoic acid was added. After an additional 4 d, 6 mL of acetone was added and stored for 2.5 d. Then 2.2 g of sodium metabisulfite in 5 mL of water was added and stirred for 2 h. Ethyl acetate was added and the mixture was washed with brine, dried over sodium sulfate, filtered and concentrated to leave a solid which was purified by chromatography (silica gel, elution with ethyl acetate/pentane), affording 3.35 g of the N-oxide. The N-oxide thus prepared (2.0 g, 11.89 mmol) in 10.53 mL of phosphorous oxychloride and 18 mL of toluene was heated at 100C for 1.5 h. The mixture was carefully treated with ice and then with saturated aqueous sodium carbonate solution. The product was extracted into ethyl acetate, and the combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (elution with ethyl acetate/pentane) to give 1.27 g of 6-chloro-pyrazine-2- carboxylic acid ethyl ester. .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/86705; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Analyzing the synthesis route of Ethyl pyrazine-2-carboxylate

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 6924-68-1, A common heterocyclic compound, 6924-68-1, name is Ethyl pyrazine-2-carboxylate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the ester derivative 8a or 8b (5.5 mmol) and hydrazine hydrate (11 mmol) in 50 mL of ethanol was heated under reflux for 6 h. The reaction mixture was left overnight at room temperature, and the solid which separated was collected by filtration. The solid was then washed with ethanol, dried, and recrystallized from ethanol (Yoshino et al., 2006; Vlaovic et al., 1990).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Abu Khalaf, Reema; Abdula, Ahmed Mutanabbi; Mubarak, Mohammad S.; Taha, Mutasem O.; Medicinal Chemistry Research; vol. 24; 6; (2015); p. 2529 – 2550;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some tips on Ethyl pyrazine-2-carboxylate

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl pyrazine-2-carboxylate, and friends who are interested can also refer to it.

Electric Literature of 6924-68-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6924-68-1 name is Ethyl pyrazine-2-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Dissolve NaOMe (1.5 eq) in toluene and heat 90C. Add a solution of 2-pyrazine methylester (1.0 eq) and methyl acetate (2.0 eq) in toluene dropwise and heat at 90C. After 20 hours, cone. in vacuo at RT. Slurry in excess methyl acetate and reflux 20 hours. Cool to RT. Add water. Extract with EtOAc, dry (Na2SO4), filter and cone. in vacuo to give the title compound: TLC Rf= 0.58 (1: 1 EtOAc/hexanes)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl pyrazine-2-carboxylate, and friends who are interested can also refer to it.