Category: 69214-34-2

Li, Jian-Yuan published the artcilePalladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis, Application In Synthesis of 69214-34-2, the main research area is palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis.

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Bioconjugate Chemistry published new progress about Carbonylation. 69214-34-2 belongs to class pyrazines, name is 8-Bromoimidazo[1,2-a]pyrazine, and the molecular formula is C6H4BrN3, Application In Synthesis of 69214-34-2.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Lumma, William C. Jr. published the artcilePiperazinylimidazo[1,2-a]pyrazines with selective affinity for in vitro α-adrenergic receptor subtypes, Name: 8-Bromoimidazo[1,2-a]pyrazine, the main research area is piperazinylimidazopyrazine preparation alpha adrenergic agonist; potential energy piperazinylimidazopyrazine; conformation piperazinylimidazopyrazine; NMR piperazinylimidazopyrazine; structure activity piperazinylimidazopyrazine.

The title compounds I (R = H, etc.; R1 = H, Cl, Me, etc.; R2 = H, piperazinyl, etc.; R3 = H, Cl, Ph, piperazinyl; R4 = H, piperazino or methylpiperazino) were prepared and evaluated in vitro for their affinity for α1- and α2-adrenergic receptors. 8-(1-piperazinyl)imidazo[1,2-a]pyrazine (II) [76537-53-6] was ∼70 times more selective than mianserin for the α2-receptor. Computer-assisted mol. modeling techniques were used to describe possible preferred conformations for receptor binding. Regioselective syntheses of the heterocyclic ring system are given. Literature NMR assignments for the imidazo[1,2-a]pyrazine ring system were made. Conformational energies for II and its 5-position isomer in relation to the semirigid mianserin were estimated Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about Molecular mechanics. 69214-34-2 belongs to class pyrazines, name is 8-Bromoimidazo[1,2-a]pyrazine, and the molecular formula is C6H4BrN3, Name: 8-Bromoimidazo[1,2-a]pyrazine.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 69214-34-2,Some common heterocyclic compound, 69214-34-2, name is 8-Bromoimidazo[1,2-a]pyrazine, molecular formula is C6H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 8.-hrornoirnidazo[ I ,2apyrazine (100 mg, 0.51 rnrnol) and selectfluor (214mg, 0.61 rnmol) in MeCN (5 mL) was heated to 70 C for 1 hour, After LCMS, it was indicatedthat starting material disappeared. The mixture was then concentrated, and the residue was purified by Prep-HPLC to give the title compound (40 mg) as a yellow solid. LRMS miz (M+H) 216.1, 218.1 found, 216.1, 218.1 required.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Bromoimidazo[1,2-a]pyrazine, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem