Category: 6863-74-7

Adding a certain compound to certain chemical reactions, such as: 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6863-74-7, COA of Formula: C5H2ClN3

Example IF (60 mg), 6-cyano-2-chloropyrazine (26 mg), KF (1 mg) and TEA (0.07 mL) were combined in a microwave tube and dissolved in ACN (2 mL). The reaction mixture was stirred in the micro wave oven at 130 C for 1 h. The reaction mixture was filtrated and purified by preparative HPLC to yield an off-white solid (9 mg; 12%). MS: m/z = 462.3 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BANNER, David; GRETHER, Uwe; HAAP, Wolfgang; KUEHNE, Holger; MAUSER, Harald; PLANCHER, Jean-Marc; WO2012/59507; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 6863-74-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 6-chloropyrazine-2-carbonitrile (lg, 7.17 mmol) in dioxane (15 mL) was added 4,4,5,5-tetramethyl-2-vinyl-l,3,2-dioxaborolane (2.21 g, 14.33 mmol), Na2C03 (1.52 g, 14.33 mmol), and Pd(dppf)Cl2 (40 mg, 0.072 mmol) under N2. The resulting mixture was stirred at 100 C overnight. After cooling to RT, the mixture was diluted with EtOAc (30 mL), washed with brine, dried over Na2SC>4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (9% EtOAc in petroleum ether) to give the title compound as a solid. LRMS m/z (Mu+Eta) 132.1 found, 132.1 required.

The chemical industry reduces the impact on the environment during synthesis 6-Chloropyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (85 pag.)WO2016/100156; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

6863-74-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To an oven-dried microwave vial was added ethyl 2-amino-1,3-oxazole-5-carboxylate (546 mg, 3.50 mmol), Cs2CO3 (2279 mg, 6.99 mmol), Pd2(dba)3 (80 mg, 0.09 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (152 mg, 0.26 mmol) and the vial was capped and purged with nitrogen. 2,4-Dichloropyridine (0.378 mL, 3.50 mmol) was added via syringe, followed by 1,4-dioxane (18 mL) (degassed) and the reaction mixture was heated to 160 C for 1 h under microwave irradiation. CH2Cl2 (40 mL) was added to the crude reaction mixture together with silica (5 g). The solvents were removed under reduced pressure and the crude product was purified by flash silica chromatography with CH2Cl2 (containing 1% methanolic ammonia) as eluent.The resulting brown solid was triturated with Et2O to give ethyl 2-(4-chloropyridin-2-ylamino)oxazole-5-carboxylate (626 mg, 67%) as a pale yellow solid, which was collected by filtration and dried under vacuum.

The synthetic route of 6-Chloropyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Noonan, Gary M.; Dishington, Allan P.; Pink, Jennifer; Campbell, Andrew D.; Tetrahedron Letters; vol. 53; 24; (2012); p. 3038 – 3043;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

6863-74-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6863-74-7 name is 6-Chloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1F (60 mg), 6-cyano-2-chloropyrazine (26 mg), KF (1 mg) and TEA (0.07 mL) were combined in a microwave tube and dissolved in ACN (2 mL). The reaction mixture was stirred in the micro wave oven at 130 C. for 1 h. The reaction mixture was filtrated and purified by preparative HPLC to yield an off-white solid (9 mg; 12%). MS: m/z=462.3 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Banner, David; Grether, Uwe; Haap, Wolfgang; Kuehne, Holger; Mauser, Harald; Plancher, Jean-Marc; US2012/115843; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6863-74-7 name is 6-Chloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 6863-74-7

EXAMPLE II-16 In a mixture of 140 ml of acetonitrile and 280 ml of toluene were suspended 58 g of potassium fluoride (spray-dried) and 8.7 g f 18-crown-6-ether. After heating the suspension under reflux for one hour in an atmosphere of nitrogen gas, the acetonitrile and toluene were distilled off under atmospheric pressure. The residue thus obtained was suspended in 280 mL of acetonitrile, 23 g of 6-chloro-2-pyrazinecarbonitrile synthesised according to the method described in Acta Poloniae Pharmaceutica, Vol. 33, Pages 153-161 (1976) was added, and the mixture thus obtained was heated under reflux for one hour in an atmosphere of nitrogen. The reaction mixture was cooled to room temperature, 280 mL of ethyl acetate and 280 mL of water were added, and the organic layer was separated. The organic layer thus obtained was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was distilled off under a reduce pressure. The residue was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=10:1] to obtain 10 g of 6-fluoro-2-pyrazinecarbonitrile as a white-colored solid product. IR (KBr) cm-1: 2244 1H-NMR (CDCl3) delta: 8.72(1H,d,J=8.1 Hz), 8.88(1H,d, J=3.7 Hz)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Chloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 6863-74-7

A mixture of tert-butyl ((1R,4R,7R)-2-(1-(azetidin-3-ylmethyl)-2-(1- (cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1H-benzo[d]imidazole- 5-carbonyl)-2-azabicyclo[2.2.1]heptan-7-yl)carbamate (15 mg, 0.024 mmol), 6- chloropyrazine-2-carbonitrile (3.34 mg, 0.024 mmol), cesium carbonate (15.62 mg, 0.048 mmol), BINAP (0.746 mg, 1.199 mmol) and Pd2(dba)3 (1.098 mg, 1.199 mmol) in degassed dioxane (1.0 mL) under nitrogen in a seal vial was stirred at 90C for 18 hour. The mixture was diluted with EtOAc (5 mL) and was washed with a solution of aqueous saturated sodium bicarbonate (5 mL). The organic layer was dried over sodium sulfate and concentrated to give crude tert-butyl ((1R,4R,7R)-2-(1-(azetidin-3-ylmethyl)-2-(1- (cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1H-benzo[d]imidazole- 5-carbonyl)-2-azabicyclo[2.2.1]heptan-7-yl)carbamate (15 mg, 0.024 mmol). Material was used as is in next reaction.

The synthetic route of 6863-74-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; NGU, Khehyong; (435 pag.)WO2020/33514; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem