Synthetic Route of 68236-03-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68236-03-3, name is 6-Chloropyrido[2,3-b]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 4.3 : 6-Vinvl-pyrido[2.3-blpyrazine (Scheme 10); 6-chloropyrido[2,3-b]pyrazine (Intermediate 4.2) (3 g, 18.12 mmol, 1.00 eq.) was dissolved in THF (150mL) and degassed with nitrogen at rt for 10 minutes. Tetrakis (triphenylphosphine) palladium(O) (1.46 g, 1.27 mmol, 0.07 eq.) and vinyltributylstannane (7.47 mL, 23.5 mmol, 1.3eq.) were added and reaction mixture was stirred at 65C for 3 hours. THF was evaporated and crude purified directly by flash chromatography using cyclohexane/ethyl acetate (8/2) to give 2.3 g of the expected compound (Intermediate 4.3) as an orange oil. Amount: 2.3g; Yield: 81%; Formula: C9H7N3; HPLC Purity: 98%; HPLC (HzO TFA 0.1%-ACN TFA Q.05%): Rt (min); Area % = 1.32 min; 98%; 1H NMR (DMSO-d6) 8 9.10 (s, 1H), 8.98 (s, 1H), 8.46 (d, 1H, J=8Hz), 7.95 (d, 1H, J= 8Hz), 6.90 (dd, 1H, Jtrans^HHz, Jcis= 10Hz), 6.50 (dd, 1H, Jt^nHz, Jgem=1.5Hz), 5.80 (dd, 1H, Jcis=10Hz, Jgem=1.5Hz). LC-MS:M/ZESI: Rt (min) 0.78 min, 158.13 (M+l).
The synthetic route of 6-Chloropyrido[2,3-b]pyrazine has been constantly updated, and we look forward to future research findings.