Category: 63286-28-2

Related Products of 63286-28-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63286-28-2 as follows.

Step 3. N’-(3-chloropyrazin-2-yl)-l-(5-ethylpyrimidin-2-yl)piperidine-4- carbohydrazide[0323] To a solution of l-(5-ethylpyrimidin-2-yl)piperidine-4-carboxylic acid (3.0 g, 13 mmol) in DMF (50 niL), was added 0-(7-Azabenzotriazol-l-yl)- N,N,N’,N’-tetramethyluronium hexafluorophosphate (5.2 g, 14 mmol), diisopropylethylamine (2.5 mL, 14 mmol), and 2-chloro-3-hydrazinylpyrazine (2.0 g, 14 mmol). After 1 h at rt, the solution is diluted with DCM (200 mL), and washed with brine (100 mL) and water (100 mL), concentrated to residue, and taken up in ethyl acetate (50 mL). The resulting precipitate is isolated by filtration to give Nu’-(3-chloropyrazin-2-yl)-l-(5-ethylpyrimidin-2-yl)piperidine-4- carbohydrazide as off-white solid (3.3 g, 71%). 1H NMR (400 MHz, DMSOd6) delta 9.89 (s, IH), 8.93 (s, IH), 8.22 (s, 2H), 8.06 (d, IH), 7.73 (d, IH), 4.60 (d, 2H), 2.92 (t, 2H), 2.56 (m, IH), 2.40 (q, 2H), 1.78 (m, 2H), 1.49 (m, 2H), 1.10 (t, 3H). LCMS: 362.2 (M+H)+.

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KALYPSYS, INC.; KAHRAMAN, Mehmet; SMITH, Nicholas, D.; BONNEFOUS, Celine; NOBLE, Stewart, A.; PAYNE, Joseph, E.; WO2010/88518; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 63286-28-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63286-28-2 name is 2-Chloro-3-hydrazinylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate b (5.0 g, 0.034 mol) was added to triethyl orthoformate (50 mL), and the reaction was carried out at 80 C. The reaction time was monitored with a plate. The reaction liquid was directly filtered with cold suction, and the filter cake was washed with petroleum ether. After the cake was dried, 4.8 g of a yellow powder was obtained with a yield of 90.1%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Liu Xiaobo; Xu Shan; Zhang Qian; Tang Qidong; Zhou Hualan; Wu Jinjin; Yuan Ping; Zhang Hongbo; (25 pag.)CN110407839; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem