Category: 63286-28-2

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Chloro-3-hydrazinylpyrazine

General procedure: To a vigorously stirred mixture of alpha-bromonitroalkane (0.50 mmol), heteroaryl hydrazine (0.60 mmol, 1.2 equiv), potassium iodide (1.0 mmol, 2.0 equiv) and potassium carbonate (1.0 mmol, 2.0 equiv) in 1,2-dimethoxyethane (5.0 mL) was added a solution of urea hydrogen peroxide in 1,2-dimethoxyethane/water (4:1) (0.50 M solution, 1.0 mL, 0.50 mmol, 1.0 equiv) over 2 h via syringe pump at r.t. After the addition was complete, the mixture was stirred for an additional 4 h. Aqueous sodium thiosulfate was then added and the mixture was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue was purified by flash column chromatography to give pure fused triazole.

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tokumaru, Kazuyuki; Bera, Kalisankar; Johnston, Jeffrey N.; Synthesis; vol. 49; 20; (2017); p. 4670 – 4675;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 63286-28-2, A common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, molecular formula is C4H5ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00145] To a solution of l-(4-chlorophenyl)cyclopropanecarboxylic acid (6300 mg, 32.0 mmol) and 4-methylmorpholine (3.87 mL, 35.2 mmol) in THF (100 mL) at 0 0C was added isobutyl chloroformate (4.21 mL, 32.0 mmol). After completion of addition, the reaction mixture was stirred for 25 min, and then a solution of 2-chloro- 3-hydrazinylpyrazine (5095 mg, 35.2 mmol) in THF (60 mL) was added. The resulting mixture was stirred for 45 min. After that time, the reaction mixture was quenched with saturated aq. NaHCtheta3 and then extracted with EtOAc (25 mL). The organic layer was collected, washed with saturated aq. NH4Cl followed by aq. NaCL, dried over Na2SO4 and then concentrated by rotary evaporation to yield compound 35A (10 g, 97 % yield) as a yellow solid. The crude product was utilized in the next step without further purification. LC/MS (m/z) = 323.1 [M+ 1] +.

The synthetic route of 63286-28-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/130951; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 63286-28-2, These common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 3-chloro-2-hydrazinopyrazine (3.0 g, 20.75 mmol), prepared from 2,3-dichloropyrazine and hydrazine using a procedure analogous to that described in the literature (Huynh-Dinh et al, J. Org. Chem. 1979, 44, 1028), was added 8 mL of triethyl orthopropionate. After refluxing for 10 h, the reaction was cooled down to ambient temperature and the precipitate was filtered. The solid was purified by flash chromatography (100% ethyl acetate, then 10% methanol in ethyl acetate) to give 2.73 g of the title compound as a solid. 1H NMR (500 MHz, CDCl3) delta 1.54 (t, 3H, J=7.6 Hz), 3.16 (q, 2H, J=7.8 Hz), 7.70 (d, 1H, J=4.5 Hz), 7.83 (d, 1H, J=4.8 Hz)

Statistics shows that 2-Chloro-3-hydrazinylpyrazine is playing an increasingly important role. we look forward to future research findings about 63286-28-2.

Reference:
Patent; Merck Sharp & Dohme Corp.; Edmondson, Scott D.; Fisher, Michael H.; Kim, Dooseop; Maccoss, Malcolm; Parmee, Emma R.; Weber, Ann E.; Xu, Jinyou; US2015/359793; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, name: 2-Chloro-3-hydrazinylpyrazine

To a solution of commercial available 2-chloro-3-hydrazinylpyrazine (28 g, 0.19 mol) in dichloromethane (200 mL) was added butyraldehyde (14.7 g, 0.20 mol) and the reaction was stirred at 50 C for 2 hours before cooling to 0 C. Diacetoxyiodobenzene (71 .8 g, 0.223 mol) was added at 0 C. Cooling was removed and the mixture was stirred at 20C for 2 hours. A saturated aq. solution of Na2CO3 (80ml_) was slowly poured into the reaction and the mixture was stirred for 10 minutes. The organic phase was separated, washed with brine (3^50 mL), dried over Na2SO4 and concentrated under vacuum. The residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and petroleum ether to give 8-chloro-3-propyl-[1 ,2,4]triazolo[4,3-a]pyrazine 20 g (53%) .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 63286-28-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixture of compound 8 (1.0 g, 1.30 mmol) and pyridine (5 mL) in anhydrous methanol (13 mL), methyl carbazate (0.434 g, 4.82 mmol) was added under the protecting of N2 and adjusted the pH to 5-6 with acetic acid. After stirring for 17 h at room temperature, the reaction solution was evaporated under reduced pressure. After adding water (10 mL) to the residue and extracted three times with an equal volume of ethyl acetate. The organic phase combined and dried with anhydrous MgSO4, concentrated under reduced pressure to afford crude product, which was further purified with chromatography on silica gel using petroleum ether/ethyl acetate (6:1) as eluant to give a white solid 0.50 g.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-3-hydrazinylpyrazine, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, COA of Formula: C4H5ClN4

Add intermediate b (5.0 g, 0.034 mol) to triethyl orthoacetate (50 mL),The reaction was performed at 80 C, and the reaction time was monitored by spotting. The reaction liquid is directly filtered by cold suction,The filter cake was washed with petroleum ether, and the filter cake was dried to obtain 4.9 g of a yellow powder.The yield was 84.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H5ClN4

Intermediate b (5.0 g, 0.034 mol) was added to triethyl orthoformate (50 mL), and the reaction was carried out at 80 C. The reaction time was monitored with a plate. The reaction liquid was directly filtered with cold suction, and the filter cake was washed with petroleum ether. After the cake was dried, 4.8 g of a yellow powder was obtained with a yield of 90.1%.

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Liu Xiaobo; Xu Shan; Zhang Qian; Tang Qidong; Zhou Hualan; Wu Jinjin; Yuan Ping; Zhang Hongbo; (25 pag.)CN110407839; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Synthetic Route of 63286-28-2,Some common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, molecular formula is C4H5ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine A mixture of 1-(3-chloropyrazin-2-yl)hydrazine (0.90 g, 62 mmol), triethyl orthoformate (2.3 mL), 14 mmol), and dry xylene (15 mL) was refluxed with stirring for 2 h. The mixture was brought to RT, diethyl ether was added and the suspension was filtered. The solid collected was washed with diethyl ether to afford 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine (0.60 g, 62% yield). MS m/z: 155.0 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-3-hydrazinylpyrazine, its application will become more common.

Reference:
Patent; Amgen Inc.; US2010/120774; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2-Chloro-3-hydrazinylpyrazine

Into a 500-mL 3 -necked round-bottom flask, was added 2-chloro-3- hydrazinylpyrazine (5.0 g, 34.59 mmol, 1.00 equiv) in tetrahydrofuran (100 mL). While stirring this solution at 0 C a solution of TFAA (8.0 g, 38.09 mmol, 1.10 equiv) in tetrahydrofuran (100 mL) was added dropwise. The resulting solution was stirred for 1 h and then washed with sodium chloride(aq). The resulting solution was extracted with ethyl acetate and the organic layers were combined and concentrated under vacuum. Purification by flash chromatography (silica gel column with ethyl acetate: petroleum ether (1:5)) provided 7.3 g (88%) of 1-1 as a white solid.

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEAYA BIOSCIENCES, INC.; BECK, Hilary, Plake; GONZALEZ-LOPEZ, Marcos; SUTTON, James, Clifford, Jr.; (86 pag.)WO2019/156989; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Electric Literature of 63286-28-2,Some common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, molecular formula is C4H5ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) To a 100 mL eggplant flask were added the above slightly red oil of (S)-2-methylpiperidine-1-carbonylchloride (0.53 g), diisopropylethylamine (1.57 mL), and dichloromethane (20 mL), 2-chloro-3-hydrazinylpyrazine (0.44 g) was added thereto under argon gas flow with stirring at room temperature, and the resulting mixture was stirred at the same temperature for 24 hours. After the reaction was completed, water was added thereto, and the resulting mixture was extracted with dichloromethane. The resulting organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residues were subjected to Moritex medium pressure preparative (Purif-Pack, SI size 20 (10 g), hexane:ethyl acetate=70:30 to 0:100), the fractions comprising the title compound were collected, concentrated under reduced pressure, ethyl acetate and diisopropyl ethyl ether were added thereto, the precipitated solid was collected by filtration, and washed with diisopropyl ethyl ether to give the title compound (23.7 mg) (yield 2.9%) as a colorless solid. MS(DUIS) m/z: 270/272 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-3-hydrazinylpyrazine, its application will become more common.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem