Category: 63286-28-2

Electric Literature of 63286-28-2,Some common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, molecular formula is C4H5ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3: 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine A mixture of 1-(3-chloropyrazin-2-yl)hydrazine (0.90 g, 62 mmol), triethyl orthoformate (2.3 mL), 14 mmol), and dry xylene (15 mL) was refluxed with stirring for 2 h. The mixture was brought to RT, diethyl ether was added and the suspension was filtered. The solid collected was washed with diethyl ether to afford 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine (0.60 g, 62% yield). MS m/z: 155.0 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-3-hydrazinylpyrazine, its application will become more common.

Reference:
Patent; Amgen Inc.; US2010/120774; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, Recommanded Product: 2-Chloro-3-hydrazinylpyrazine

Add trifluoroacetic anhydride to the flask, use ethyl acetate as a solvent, stir in an ice bath, add ethyl acetate to intermediate b (5g, 0.0346mol) and sonicate to mix thoroughly, then slowly add trifluoroacetic anhydride. , Stir in an ice bath, check the progress of the reaction by spotting the plate. After the reaction, the solution was directly extracted with NaOH solution and ethyl acetate, and the organic phase was collected to be rotary-evaporated to obtain an oil. After drying, 10.9 g of a gray solid was obtained with a yield of 93.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Xu Shan; Liu Xiaobo; Zhang Qian; Zhou Lingjia; Han Haoyun; Yu Li; Zhou Hualan; Qiu Yufeng; (25 pag.)CN110467616; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Chloro-3-hydrazinylpyrazine

To a 0 0C solution of 2-(4-chlorophenyl)-2-methylpropanoic acid (99.3 mg, 0.50 mmol) in THF (2 mL) was added 4-methylmorpholine (60.5 muL, 0.55 mmol). After 10 minutes, isobutyl chloroformate (67.4 muL, 0.52 mmol) was added dropwise over 2 minutes. After 2.5 h, a solution of Compound IA (72.3mg, 0.50 mmol) in THF (3 mL) was added dropwise over 2 minutes. After 10 minutes the cooling bath was removed and the reaction mixture was warmed to room temperature. After 3 h at room temperature, water (5 mL) and ethyl acetate (10 mL) were added, and the resulting mixture was stirred for 10 minutes. At the conclusion of this period, the organic phase was separated, dried over Na2SO4, and then concentrated in vacuo to yield a residue. The residue was purified by flash chromatography (SiC^ , 0-100% ethyl acetate / hexanes) to provide compound IB, which was used directly in the preparation of compound 1C set forth below. LC/MS (m/z) = 325 (M+H)+.

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/130951; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Related Products of 63286-28-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2-chloro-3-hydrazinopyrazine (8.51 g, 58.9 mmol), 1-fluoro-2-(2,2,2-triethoxyethyl)benzene from 1(A) (34.7 g, 135 mmol) and xylene (125 mL) (dried over calcium chloride) was refluxed for 3 hours. The solvent was removed by spin evaporation in vacuo. The solid residue was triturated in ether (200 mL) and the solid was collected by suction filtration. The solid was rinsed with ether and dried with aspirator suction to give 14.9 g (96%) of crude 3-benzyl-8-chloro-1,2,4-triazolo[4,3-a]pyrazine.

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-3-hydrazinylpyrazine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Burroughs Wellcome Co.; US5095018; (1992); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, Safety of 2-Chloro-3-hydrazinylpyrazine

It was stirred for 4 hours at reflux mixture of the compound obtained in Step 1 (8 g) and triethyl orthoformate (32 mL). The reaction solution was cooled to room temperature, the precipitated solid was washed after filtration, with ethanol, To give the title compound followed by drying under reduced pressure (8.10g, 95%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; MINAMIGUCHI, KAZUHISA; OKAJIMA, SHIGEO; AOKI, SHINICHI; ASAI, MASANORI; ASAI, TAKAHIRO; YAMANAKA, HIROYOSHI; DOHI, SUGURU; (149 pag.)JP5851663; (2016); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

(2) To a 100 mL eggplant flask were added the yellow oil (1.65 g) prepared in the above step, 2-chloro-3-hydrazinylpyrazine (1.26 g), and diisopropylethylamine (4.56 mL) under argon gas flow, and the resulting mixture was stirred at 80 C. for 4 hours. (1716) After the reaction was completed, the mixture was concentrated under reduced pressure, water was added thereto, and the resulting mixture was extracted with ethyl acetate. The resulting organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residues were subjected to silica gel chromatography (hexane:ethyl acetate=70:30 to 50:50) using YAMAZEN medium pressure preparative (Silica L (40 g)), the fractions comprising the target compound (Rf value=0.25 (hexane:ethyl acetate=1:1)) were collected, concentrated under reduced pressure, to the resulting residues was added diisopropyl ether, the precipitated solid was filtered, and dried under reduced pressure to give the title compound (1.53 g) (yield 62%) as a white solid. (1717) MS(CI) m/z: 284/286 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 63286-28-2,Some common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, molecular formula is C4H5ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 141-2 Preparation of N’-(3-chloropyrazin-2-yl)cyclohexanecarbohydrazide To a mixture of 2-chloro-3-hydrazinylpyrazine (1.10 g), triethylamine (1.27 mL), and chloroform (38 mL) in a 200 mL eggplant flask was added cyclohexanecarbonyl chloride (1.13 mL) under ice-cooling, and the resulting mixture was stirred at room temperature for 1 hour. To the reaction mixture were added a saturated aqueous solution of sodium hydrogen carbonate (40 mL), saturated brine (40 mL), and ethyl acetate (120 mL), and the resulting mixture was stirred for a while. The resulting organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and the insoluble matters were removed by filtration. The resulting filtrate was concentrated under reduced pressure to give the title compound (1.53 g) (yield 79%) as a pale yellow solid. MS(ESI) m/z: 255/257 [M+H]+

The synthetic route of 63286-28-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Chloro-3-hydrazinylpyrazine

A mixture of l-(3-chloropyrazin-2-yl)hydrazine (0.90 g, 62 mmol), triethyl orthoformate (2.3 mL), 14 mmol), and dry xylene (15 mL) was refluxed with stirring for 2 h. The mixture was brought to RT, diethyl ether was added and the suspension was filtered. The solid collected was washed with diethyl ether to afford 8-chloro-[l,2,4]triazolo[4,3- ajpyrazine (0.60 g, 62% yield). MS m/z: 155.0 (M+l).

The synthetic route of 2-Chloro-3-hydrazinylpyrazine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AMGEN INC.; WO2009/64418; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C4H5ClN4

It was stirred for 4 hours at reflux mixture of the compound obtained in Step 1 (8 g) and triethyl orthoformate (32 mL). The reaction solution was cooled to room temperature, the precipitated solid was washed after filtration, with ethanol, To give the title compound followed by drying under reduced pressure (8.10g, 95%).

According to the analysis of related databases, 63286-28-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAIHO PHARMACEUTICAL COMPANY LIMITED; MINAMIGUCHI, KAZUHISA; OKAJIMA, SHIGEO; AOKI, SHINICHI; ASAI, MASANORI; ASAI, TAKAHIRO; YAMANAKA, HIROYOSHI; DOHI, SUGURU; (149 pag.)JP5851663; (2016); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 63286-28-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63286-28-2 name is 2-Chloro-3-hydrazinylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example 17-2 Preparation of N’-(3-chloropyrazin-2-yl)-1,2,3,4-tetrahydronaphthalene-1-carbohydrazide racemate To a 30 mL cylindrical flask were added 2-chloro-3-hydrazinylpyrazine (470 mg), tetrahydrofuran (5 mL), 1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (573 mg), triethylamine (550 muL), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (700 mg) under argon atmosphere, and the resulting mixture was stirred at room temperature for 3 hours. To the reaction mixture were additionally added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (350 mg) and triethylamine (280 muL), and the resulting mixture was stirred at room temperature for additional 2 hours. The reaction mixture was added to a saturated aqueous solution of sodium hydrogen carbonate, and the resulting mixture was extracted with ethyl acetate. The resulting organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residues were subjected to silica gel column chromatography (Rf value=0.23 (solvent: hexane/ethyl acetate=1:1)) (Silica L (40 g), hexane/ethyl acetate=52/48 to 31/69) using YAMAZEN medium pressure preparative column, and the fractions comprising the target compound were concentrated under reduced pressure to give the title compound (308 mg) (yield 31%) as a white solid. MS(CI) m/z: 303/305 [M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; UBE INDUSTRIES, LTD.; NAKAJIMA, Tatsuo; HAYASHI, Norimitsu; ISHIZAWA, Kouhei; TSUZAKI, Yasunori; IWAMURA, Ryo; TSUBOIKE, Kazunari; US2019/185479; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem