Category: 6294-70-8

Related Products of 6294-70-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6294-70-8, name is 5,6-Dimethylpyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To an acetonitrile solution (8.00 mL) of the compound (519 mg) obtained in Reference Example 433 was added N-bromosuccinimide (749 mg) at 0C, and the reaction mixture was stirred at room temperature for 30 min. Aqueous sodium thiosulfate solution was added and the mixture was extracted twice with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated, and the obtained residue was purified by silica gel column chromatography (solvent; hexane/ethyl acetate=100/0 – 60/40) to give the title compound (619 mg). MS(ESI)m/z; 202,204[M+H]+

The synthetic route of 5,6-Dimethylpyrazin-2-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; OKUYAMA, Masahiro; FUKUNAGA, Kenji; USUI, Kenji; HAYASHI, Norimitsu; IIJIMA, Daisuke; HORIUCHI, Hideki; FUJIMOTO, Nobuaki; (218 pag.)EP3372601; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6294-70-8, name is 5,6-Dimethylpyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 6294-70-8

To an acetonitrile solution (8.00 mL) of the compound (519 mg) obtained in Reference Example 433 was added N-bromosuccinimide (749 mg) at 0C, and the reaction mixture was stirred at room temperature for 30 min. Aqueous sodium thiosulfate solution was added and the mixture was extracted twice with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated, and the obtained residue was purified by silica gel column chromatography (solvent; hexane/ethyl acetate=100/0 – 60/40) to give the title compound (619 mg). MS(ESI)m/z; 202,204[M+H]+

According to the analysis of related databases, 6294-70-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; OKUYAMA, Masahiro; FUKUNAGA, Kenji; USUI, Kenji; HAYASHI, Norimitsu; IIJIMA, Daisuke; HORIUCHI, Hideki; FUJIMOTO, Nobuaki; (218 pag.)EP3372601; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6294-70-8, name is 5,6-Dimethylpyrazin-2-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 6294-70-8

At room temperature,Potassium tert-butoxide (5.60 g, 50 mmol)To a solution of 5,6-dimethylpyrazin-2-amine (1.23 g, 10 mmol)In 250 ml of dry THF.After stirring for 15 minutes,2-Nitrothiazole-4-carbonyl chloride (2.10 g, 11 mmol)In 50 ml of dry THF.The reaction mixture was stirred for 4 hours at room temperature,Then poured into saturated aqueous NaHCO 3 solution and extracted with EtOAc.The organic phase was washed with saturated aqueous NaCl solution,Dry over anhydrous Na2SO4 and concentrate to dryness.After purification by silica gel flash chromatography (cyclohexane / EtOAc: 90/10 to 50/50)Obtained as a white solid1.69 g of N- (5,6-dimethylpyrazin-2-yl) -2-nitrothiazole-4-amide(Yield: 61.0%).

The synthetic route of 6294-70-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mudanjiang Medical School; Liu Shijuan; Hou Jiafu; Li Xuemei; Zhou Xue; Wu Yiyan; Zhao Cong; Tong Lei; Zhang Chaoli; Liu Jiawei; Cui Xinyu; (11 pag.)CN107056819; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem