Category: 6270-63-9

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6270-63-9, name is Pyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: Pyrazin-2(1H)-one

General procedure: The appropriate nucleophile (1 equiv.), the epoxide (1-3 equiv.) and a base (1-5 equiv.) were suspended in a solvent and the reaction mixture was heated under the stated conditions. (0735) The reaction was allowed to cool to rt, saturated NH4CI(aq) or water was added and the resulting mixture was extracted using DCM or EtOAc (x 3). The combined organic extracts were dried (phase separator or MgS04), concentrated under reduced pressure and the remaining residue was purified by flash chromatography to give the product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; WHITEHEAD, Steven Kristopher; TREDER, Adam Piotr; PROCTOR, Lauren Emma; SHEPHERD, Steven David; BURKAMP, Frank; COSTA, Joana Rita Castro; O’DOWD, Colin; HARRISON, Timonthy; (333 pag.)WO2019/150119; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6270-63-9, name is Pyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., Formula: C4H4N2O

General procedure: The appropriate nucleophile (1 equiv.), the epoxide (1-3 equiv.) and a base (1-5 equiv.) were suspended in a solvent and the reaction mixture was heated under the stated conditions. (0735) The reaction was allowed to cool to rt, saturated NH4CI(aq) or water was added and the resulting mixture was extracted using DCM or EtOAc (x 3). The combined organic extracts were dried (phase separator or MgS04), concentrated under reduced pressure and the remaining residue was purified by flash chromatography to give the product.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; WHITEHEAD, Steven Kristopher; TREDER, Adam Piotr; PROCTOR, Lauren Emma; SHEPHERD, Steven David; BURKAMP, Frank; COSTA, Joana Rita Castro; O’DOWD, Colin; HARRISON, Timonthy; (333 pag.)WO2019/150119; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6270-63-9, name is Pyrazin-2(1H)-one, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines

Example 181; (1SR,2RS)-1-methyl-cyclopropane-1,2-dicarboxylic acid 2-[(5-chloro-pyridin-2-yl)-amide]1-{[2-fluoro-4-(2-oxo-pyrazin-1-yl)-phenyl]-amide}; In analogy to example 178, step 3, (1SR,2RS)-2-(5-chloro-pyridin-2-ylcarbamoyl)-1-methyl-cyclopropanecarboxylic acid methyl ester (example 178, step 2) was reacted with 1-(4-amino-3-fluoro-phenyl)-1H-pyrazin-2-one (prepared from 2-fluoro-4-iodoaniline by reaction with 1H-pyrazin-2-one, Cu(I)I, N,N’-dimethylethylenediamine and cesium carbonate in dioxane at 120 C.) to give (I SR,2RS)-1-methyl-cyclopropane-1,2-dicarboxylic acid 2-[(5-chloro-pyridin-2-yl)-amide]1-{[2-fluoro-4-(2-oxo-pyrazin-1-yl)-phenyl]-amide} as off-white solid. MS 440.3 ([M-H]-).

According to the analysis of related databases, 6270-63-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer, Markus; Zbinden, Katrin Groebke; Haap, Wolfgang; Hilpert, Hans; Himber, Jacques; Humm, Roland; Iding, Hans; Knopp, Dietmar; Panday, Narendra; Ricklin, Fabienne; Stahl, Christoph Martin; US2006/106016; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some common heterocyclic compound, 6270-63-9, name is Pyrazin-2(1H)-one, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 6270-63-9

1-(4-amino-3-fluoro-phenyl)-1H-pyrazin-2-one (prepared from 2-fluoro-4-iodoaniline by reaction with 1H-pyrazin-2-one, Cu(I)I, N,N’-dimethylethylenediamine and cesium carbonate in dioxane at 120 C.)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6270-63-9, its application will become more common.

Reference:
Patent; Zbinden, Katrin Groebke; Haap, Wolfgang; Hilpert, Hans; Panday, Narendra; Ricklin, Fabienne; Wirz, Beat; US2006/247238; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 6270-63-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6270-63-9, name is Pyrazin-2(1H)-one belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A solution of N-((3-chloro-lH-indol-5-yl)methyl)-5-(4-(chloromethyl)benzyl)nicotinamide (90 mg, 0.21 mmol, 1.0 eq), pyrazin-2(lH)-one (41 mg, 0.42 mmol, 2.0 eq) and K2C03 (58 mg, 0.42 mmol, 2.0 eq) in MeCN (10 mL) was stirred at 80 C for 2 h and allowed to cool. The mixture was concentrated. The residue was purified by flash chromatography (MeCN/l hO = 1/2 to 19/1) to afford N-((3-chloro-lH-indol-5- yl)methyl)-5-(4-((2-oxopyrazin-l(2H)-yl)methyl)benzyl)nicotinamide as a white solid (6.3 mg, 6%). LRMS (M+H+) m/z calculated 484.1, found 484.1. NMR (DMSO-ifc, 400 MHz) delta 8.72 (s, 1 H), 8.44 (s, 1 H), 7.97 (s, 1 H), 7.95 (d, 1 H), 7.47 (d, 1 H), 7.40 (s, 1 H), 7.26-7.20 (m, 4 H), 7.16-7.10 (m, 3 H), 7.10-7.08 (m, 1 H), 5.00 (s, 2 H), 4.55 (s, 2 H), 3.96 (s, 2 H).

The synthetic route of Pyrazin-2(1H)-one has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Application of 6270-63-9, A common heterocyclic compound, 6270-63-9, name is Pyrazin-2(1H)-one, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of compound pyrazin-2(1H)-one (11.0 g, 114 mmol), Mg(Ot-Bu)2 (39.0 g, 229 mmol) and t-BuOK (13.5 g, 120 mmol) in THF (220 mL) was stirred at 25 C. for 20 min under N2. And then compound (R)-2-bromo-4-methylpentanoic acid (33.5 g, 172 mmol) was added drop-wise into the mixture. The reaction was stirred at 25 C. for 20 hrs. HCl (3.0 M, 153 mL) was added dropwise to the mixture. The organic phase was washed with brine (100 mL), and concentrated. The mixture was purified by SFC (Instrument: Thar SFC80 preparative SFC; Column: Chiralpak AD-H 250*30 mm i.d. 5u; Mobile phase: A for CO2 and B for IPA (0.1% NH3H2O); Gradient: B %=35%; Flow rate: 75 g/min; Wavelength: 220 nm; Column temperature: 40 C.; System back pressure: 100 bar; Cycle time:13 min; Injection amount: 105 mg per injection) to give (S)-4-methyl-2-(2-oxopyrazin-1(2H)-yl)pentanoic acid (15.0 g, 61.7% Yield, 99.0% purity) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 7.96 (d, J=5.6 Hz, 1H), 7.58 (d, J=4.8 Hz, 1H), 7.30 (d, J=4.4 Hz, 1H), 5.14-5.21 (m, 1H), 1.84-1.92 (m, 2H), 1.17-1.26 (m, 1H), 0.82-0.84 (m, 6H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6270-63-9, name is Pyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., Quality Control of Pyrazin-2(1H)-one

To a solution of methyl 5-( I -bromo-3-cyclopropylpropyl)-2-fluorophenylcarbamate(258c) (0.925 g, 2.80 rnmol) in DMF (10 mL) was added pyrazin-2(LH)-one (0.323 g, 3.36mmol) cesium carbonate (0.867 g, 2.66 mmol) and stirred at room temperature overnight. The reaction mixture was diluted with water (50 mL), extracted with ethyl acetate (2 x 75 rnL), combined organics were dried over anhydrous MgSO4, filtered and evaporated to dryness. The residue was purified by flash column chromatography [silica gel 24 g, elutingwith ethyl acetate/methanol (9: 1) in hexanes from 0-75%] to furnish methyl 5-(3-cyc lopropyl- 1 -(2-oxopyrazin- 1(2 H)-yl)propyl)-2-fl uorophenylcarbamate (259a) (0.304 g, 31 % yield) as a colorless wax. MS (ES+): 368.3 (M+Na), MS (ES-) 344.2 (M-l).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; WU, Minwan; CHINTAREDDY, Venkat, R.; KUMAR, V., Satish; ZHANG, Weihe; WO2015/134998; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6270-63-9, name is Pyrazin-2(1H)-one belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Safety of Pyrazin-2(1H)-one

To Pyrazin-2(1H)-one (0.333 g, 3.47 mmol) was added 5 N sodium hydroxide solution (2.1 ml) followed by chloroacetic acid (0.524 g, 5.54 mmol). The reaction mixture was heated at 100C for 2 h. After cooling to ambient temperature, 2 N hydrochloric acid (3.5 ml) was added and the reaction mixture was directly purified by reverse phase etaPLC (TMC Pro-Pac C18; 0-40% 0.1% trifluoroacetic acid in acetonitrile/ 0.1% trifluoroacetic acid in water gradient). The pure fractions were lyophilized overnight to yield the title compound as a yellow solid. LC/MS 155.2 (M+l)+.

The synthetic route of 6270-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2009/123870; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6270-63-9, name is Pyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., name: Pyrazin-2(1H)-one

Weigh the pyrazin-2(1H)-one (481 mg, 5 mmol) in a 50 mL single-mouth bottle. Add anhydrous N,N-dimethylformamide (6 mL), Sodium hydride (240 mg, 6 mmol, 60%) was added and the mixture was stirred at room temperature. Weighed after 20 minutes Ethyl 2-bromoacetate (1.0 g, 10.0 mmol, Dissolved in 4 mL of anhydrous N,N-dimethylformamide) and added dropwise to the reaction flask. After the addition was completed, the reaction was stirred at room temperature overnight. Stop the reaction, The reaction was quenched by dropwise addition of water (2 mL). Add water (30mL), Extracted with ethyl acetate (30 mL ¡Á 3), Combine the organic phase to concentrate, The residue was purified by column chromatography ( petroleum ether / ethyl acetate (v / v) = 1 / 1) The title compound was obtained as a pale yellow liquid (360 mg, 40%).

The synthetic route of 6270-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Xu Tengfei; Jin Chuanfei; Zhong Wenhe; Xue Yaping; (45 pag.)CN109761892; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

These common heterocyclic compound, 6270-63-9, name is Pyrazin-2(1H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6270-63-9

General procedure: The appropriate nucleophile (1 equiv.), the epoxide (1-3 equiv.) and a base (1-5 equiv.) were suspended in a solvent and the reaction mixture was heated under the stated conditions. (0735) The reaction was allowed to cool to rt, saturated NH4CI(aq) or water was added and the resulting mixture was extracted using DCM or EtOAc (x 3). The combined organic extracts were dried (phase separator or MgS04), concentrated under reduced pressure and the remaining residue was purified by flash chromatography to give the product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6270-63-9.

Reference:
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; WHITEHEAD, Steven Kristopher; TREDER, Adam Piotr; PROCTOR, Lauren Emma; SHEPHERD, Steven David; BURKAMP, Frank; COSTA, Joana Rita Castro; O’DOWD, Colin; HARRISON, Timonthy; (333 pag.)WO2019/150119; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem