Category: 61892-95-3

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61892-95-3 as follows. COA of Formula: C6H8N2O

To a solution of (5-methylpyrazin-2-yl)methanol (500 mg, 4.028 mmol, commercial source: Combi- Blocks) in dichloromethane (20 mL), thionyl chloride (0.35 mL, 4.825 mmol, Commercial source: Avra) was added slowly at 0 C. The reaction mixture was allowed to reach 26 C and stirred for 16 h at the same temperature. Upon completion, the reaction mixture was concentrated under reduced pressure. The residue was neutralized with saturated sodium bicarbonate solution (20 mL) and extracted with ethyl acetate (3×20 mL). The combined organic solution was dried over Na2S04, filtered and the filtrate was concentrated under reduced pressure to afford 2- (chloromethyl)-5-methylpyrazine (500 mg, crude) as a brown liquid.1H NMR (400 MHz, CDCI3) delta 8.60 (s, 1 H), 8.43 (s, 1 H), 4.67 (s, 2H), 2.59 (s, 3H). MS m/z [M+H]+= 143.04

According to the analysis of related databases, 61892-95-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ALEMPARTE-GALLARDO, Carlos; ENCINAS, Lourdes; ESQUIVIAS PROVENCIO, Jorge; (206 pag.)WO2019/34729; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61892-95-3, name is (5-Methylpyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., Computed Properties of C6H8N2O

EXAMPLE 3 5-methyl-2-pyrazinylmethyl pivalate To a solution of 2-hydroxymethyl-5-methylpyrazine (6.2 g) and triethylamine (6.4 ml) in anhydrous benzene (150 ml) dropwise addition was made of a solution of pivaloyl chloride (6.15 ml) in anhydrous benzene (50 ml). The solution was maintained at boiling for 7 hours, the solvent was then evaporated and the residue treated with acetone. After filtration of the insoluble solid, the filtrate was evaporated to dryness and the residue re-dissolved in chloroform. The chloroform solution was first dehydrated and then evaporated to dryness, obtaining 7 g (71.5%) of 5-methyl-2-pyrazinylmethyl pivalate, b.p.=74 C./0.1 mmHg. The following compounds were similarly obtained: 2-pyrazinylmethyl pivalate; 5-fluoro-2-pyrazinylmethyl pivalate; 5-chloro-2-pyrazinylmethyl pivalate; 5-bromo-2-pyrazinylmethyl pivalate; 5-methoxy-2-pyrazinylmethyl pivalate; 3-amino-2-pyrazinylmethyl pivalate; 5-amino-2-pyrazinylmethyl pivalate; 6-amino-2-pyrazinylmethyl pivalate; 6-methyl-2-pyrazinylmethyl pivalate; 3-methyl-2-pyrazinylmethyl pivalate; 5,6-dimethyl-2-pyrazinylmethyl pivalate; 2-pyrazinylmethyl propionate; 6-methyl-2-pyrazinylmethyl propionate; 5-methyl-2-pyrazinylmethyl propionate; 5,6-dimethyl-2-pyrazinylmethyl propionate; 5-fluoro-2-pyrazinylmethyl propionate; 5-chloro-2-pyrazinylmethyl propionate; 5-bromo-2-pyrazinylmethyl propionate; 5-methoxy-2-pyrazinylmethyl propionate; 3-amino-2-pyrazinylmethyl propionate; 5-amino-2-pyrazinylmethyl propionate; 6-amino-2-pyrazinylmethyl propionate; 2-pyrazinylmethyl acrylate; 5-methyl-2-pyrazinylmethyl acrylate; 6-methyl-2-pyrazinylmethyl acrylate; 3-methyl-2-pyrazinylmethyl acrylate; 5,6-dimethyl-2-pyrazinylmethyl acrylate; 5-fluoro-2-pyrazinylmethyl acrylate; 5-chloro-2-pyrazinylmethyl acrylate; 5-bromo-2-pyrazinylmethyl acrylate; 5-methoxy-2-pyrazinylmethyl acrylate; 5-amino-2-pyrazinylmethyl acrylate; 3-amino-2-pyrazinylmethyl acrylate; 6-amino-2-pyrazinylmethyl acrylate; 2-pyrazinylmethyl-cyclohexylcarboxylate; [(5-methyl)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(6-methyl-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(3-methyl)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(5-fluoro)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(5-chloro)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(5-bromo)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(5-methoxy)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(5-amino)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(6-amino)-2-pyrazinylmethyl]-cyclohexylcarboxylate; [(3-amino)-2-pyrazinylmethyl]-cyclohexylcarboxylate.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Farmitalia Carlo Erba S.p.A.; US4267327; (1981); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem