Category: 59489-39-3

Reference of 59489-39-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59489-39-3 as follows.

3,5-dibromo-6- chloropyrazin-2-amine (Rz = Cl) was prepared according to Organic Letters, 17(15), 3888- 3891; 2015. 6-amino-3,5-dibromopyrazine-2-carbonitrile (Rz = CN) was prepared as follows.6-Aminopyrazine-2-carbonitrile (ig, 8.3 mmol) was dissolved in dichloromethane (15 mL). To this solution, NBS (2.96g, 16.65 mmol, 2 eq.) was added, and the reaction mixture was stirred at room temperature overnight (16 h). The reaction mixture was poured into water and extracted with dichloromethane, dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified using silica gel chromatography with Heptane/EtOAc as eluent providing 6-amino-3,5-dibromopyrazine-2-carbonitrile (Rz = CN)

According to the analysis of related databases, 59489-39-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PROMEGA CORPORATION; HALL, Mary; KIRLAND, Thomas; MACHLEIDT, Thomas; SHAKHMIN, Anton; WALKER, Joel, R.; (141 pag.)WO2018/22865; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59489-39-3 as follows. HPLC of Formula: C5H4N4

To a solution of 6-aminopyrazine-2-carbonitrile (l .Og, 8.33mmol, l .Oeq) in acetonitrile (0.5mL) was added N-Bromosuccinimide (2.22g, 12.50mmol,I .5eq). The reaction was stirred at room temperature for 12h. After completion of reaction, reaction mixture was transferred in water and extracted with ethyl acetate. Combined organic layer was washed with brine, dried over sodium sulphate and concentrated under reduced pressure to obtain crude material. This was further purified by column chromatography using 20percent ethyl acetate in hexane to obtain pure 151.1 (0.75g, 45.27percent). MS(ES): m/z 200.01 [M+H]+

According to the analysis of related databases, 59489-39-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reference of 59489-39-3,Some common heterocyclic compound, 59489-39-3, name is 2-Amino-6-cyanopyrazine, molecular formula is C5H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 5 (500 mg, 1.13 mmol) , 6-aminopyrazine-2-carbonitrile (163 mg, 1.36 mmol) , palladium (II) acetate (84 mg, 0.374 mmol) , xantphos (215 mg, 0.374 mmol) and cesium carbonate (741 mg, 2.27 mmol) in 1, 4-dioxane (10 mL) under heating at 110 for 1 hour through microwave irradiation under N2 atmosphere. LC-MS: m/z 526.2 (M+H) +.

The synthetic route of 59489-39-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem