Category: 59303-10-5

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59303-10-5 as follows. Computed Properties of C5H5ClN2

The rac- I -((2S,3R,4R)-4-amino-2-ethyl-6-fluoro-3-methyl-3,4-dihyd roquinolin- I (2H)-yl)ethanone (for a preparation see Intermedaite 40, 100 mg, 0.400 mmol), 2-chloro-5-methylpyrazine (77mg, 0.599mmo1), Pd2(dba)3 (54.9 mg, 0.060 mmol), sodium tert-butoxide (115 mg, 1.199 mmol) andDavePhos (15.72 mg, 0.040 mmol) were suspended I ,4-dioxane (10 mL) and allowed to stir at 100C for 18 h. The reaction was allowed to cool to rt and were filtered through celite and concentratedto a gum. This gum was purified using a MDAP (Formic) to give a solid, this solid was eluted througha NH2 SPE (5 g) with MeOH, the eluent was concentrated and dried to give the product (50 mg,0.146 mmol, 36.6%) as an off-white solid. LCMS (2 mm Formic): Rt = 0.89 mi [MH] = 343.

According to the analysis of related databases, 59303-10-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59303-10-5, name is 2-Chloro-5-methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. 59303-10-5

A solution of rac- I -((2S,3R,4R)-4-am ino-2-cyclopropyl-3-methyl-6-morpholino-3,4-dihydroqu inolin1(2H)-yl)ethanone (for a preparation see Intermediate 83, 100 mg, 0.304 mmol), DavePhos (11.95mg, 0.030 mmol), 2-chloro-5-methylpyrazine (46.8 mg, 0.364 mmol), Pd2(dba)3 (13.90 mg, 0.015 mmol) and sodium tert-butoxide (58.3 mg, 0.607 mmol) in 1,4-dioxane (3 mL) was stirred under nitrogen at 90 C for 20 h. The reaction mixture was allowed to cool to rt, filtered through celite and rinsed with ethyl acetate. The solvent was evaporated in vacuo then the sample was dissolved in 1:1 MeOH:DMSO (1 mL) and purified by MDAP (HpH). The appropriate fractions were combined andconcentrated in vacuo to give the title compound (36 mg, 0.085 mmol, 28%). LCMS (2 mm Formic): Rt = 0.84 mi [MH] = 422.

The synthetic route of 59303-10-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; AMANS, Dominique; ATKINSON, Stephen John; HARRISON, Lee Andrew; HIRST, David Jonathan; LAW, Robert Peter; LINDON, Matthew; PRESTON, Alexander; SEAL, Jonathan Thomas; WELLAWAY, Christopher Roland; WO2014/140076; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem