Category: 591-54-8

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Aminopyrimidine, is researched, Molecular C4H5N3, CAS is 591-54-8, about Generation and on-demand initiation of acute ictal activity in rodent and human tissue, the main research direction is seizure cortex optogenetics neurotransmitters.SDS of cas: 591-54-8.

Controlling seizures remains a challenging issue for the medical community. To make progress, researchers need a way to extensively study seizure dynamics and investigate its underlying mechanisms. Acute seizure models are convenient, offer the ability to perform electrophysiol. recordings, and can generate a large volume of electrog. seizure-like (ictal) events. The promising findings from acute seizure models can then be advanced to chronic epilepsy models and clin. trials. Thus, studying seizures in acute models that faithfully replicate the electrog. and dynamical signatures of a clin. seizure will be essential for making clin. relevant findings. Studying ictal events in acute seizure models prepared from human tissue is also important for making findings that are clin. relevant. The key focus in this paper is on the cortical 4-AP model due to its versatility in generating ictal events in both in vivo and in vitro studies, as well as in both mouse and human tissue. The methods in this paper will also describe an alternative method of seizure induction using the Zero-Mg2+ model and provide a detailed overview of the advantages and limitations of the epileptiform-like activity generated in the different acute seizure models. Moreover, by taking advantage of com. available optogenetic mouse strains, a brief (30 ms) light pulse can be used to trigger an ictal event identical to those occurring spontaneously. Similarly, 30 – 100 ms puffs of neurotransmitters (Gamma-Amino Butyric Acid or glutamate) can be applied to the human tissue to trigger ictal events that are identical to those occurring spontaneously. The ability to trigger ictal events on-demand in acute seizure models offers the newfound ability to observe the exact sequence of events that underlie seizure initiation dynamics and efficiently evaluate potential anti-seizure therapies.

After consulting a lot of data, we found that this compound(591-54-8)SDS of cas: 591-54-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Aminopyrimidine, is researched, Molecular C4H5N3, CAS is 591-54-8, about Synthesis of novel structural hybrids between aza-heterocycles and azelaic acid moiety with a specific activity on osteosarcoma cells, the main research direction is azelaic acid oxononanoate anticancer agent HDAC mol docking osteosarcoma; 9-hydroxystearic acid; azelaic acid; cancer; molecular docking; osteosarcoma; pyridine; pyrimidine.COA of Formula: C4H5N3.

Nine compounds bearing pyridinyl (or piperidinyl, benzimidazolyl, benzotriazolyl) groups bound to an azelayl moiety through an amide bond were synthesized. The structural analogy with some histone deacetylase inhibitors inspired their syntheses, seeking new selective histone deacetylase inhibitors (HDACi). The azelayl moiety recalls part of 9-hydroxystearic acid, a cellular lipid showing antiproliferative activity toward cancer cells with HDAC as a mol. target. Azelayl derivatives bound to a benzothiazolyl moiety further proved to be active as HDACi. The novel compounds were tested on a panel of both normal and tumor cell lines. Non-specific induction of cytotoxicity was observed in the normal cell line, while three of them induced a biol. effect only on the osteosarcoma (U2OS) cell line. One of them induced a change in nuclear shape and size. Cell-cycle alterations are associated with post-transcriptional modification of both H2/H3 and H4 histones. In line with recent studies, revealing unexpected HDAC7 function in osteoclasts, mol. docking studies on the active mols. predicted their proneness to interact with HDAC7. By reducing side effects associated with the action of the first-generation inhibitors, the herein reported compounds, thus, sound promising as selective HDACi.

After consulting a lot of data, we found that this compound(591-54-8)COA of Formula: C4H5N3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: 4-Aminopyrimidine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Aminopyrimidine, is researched, Molecular C4H5N3, CAS is 591-54-8, about Design, synthesis, molecular docking and cytotoxic activity of novel urea derivatives of 2-amino-3-carbomethoxythiophene. Author is Vikram, Venugopalarao; Penumutchu, Srinivasa R.; Vankayala, Raviraj; Thangudu, Suresh; Amperayani, Karteek Rao; Parimi, Umadevi.

An efficient feasible route for the one-pot synthesis of novel series of urea derivatives (2a-2j) from 2-amino-3-carbomethoxythiophene (1) via in situ isocyanate has been developed, and their corresponding anticancer activities were accomplished. The series of urea derivatives were characterized by using 1H, 13C NMR and mass spectroscopic anal. The cytotoxic activities were evaluated against human cervical (HeLa) and human lung (NCI-H23) cancer cell lines. These studies revealed satisfactory activity for some of the compounds, which could potentially serve as lead compounds for drug discovery and development. Furthermore, mol. docking studies supported in identifying the potential binding sites between the urea derivatives and eukaryotic ribonucleotidereductase (RR). High ambiguity driven docking (HADDOCK) modeling was specifically employed to determine the model complex of RR and urea derivatives The proposed model has provided a deep insight into the mol. level interactions of RR-urea model complexes in understanding the exact pharmacophore for designing highly potent RR inhibitors. Overall, the present work has shed light in developing a feasible and robust approach for the synthesis of novel urea derivatives of 2-amino-3-carbomethoxythiophene and identified a part of mol. structure that is responsible for a specific biol. interaction leading to potential anticancer activities. Graphic abstract: We report herein, the exptl. design, synthesis and characterization of a novel series of urea derivatives of 2-amino-3carbomethoxythiophene with pyrimidine amine and benzyl amine analogs as both derivatives which exhibited potential antitumor activity via one pot synthesis and subsequently studied the structure activity relationships (SAR), and anticancer activities. The docking studies identified a part of molecularstructure that is responsible for a specific biol. interaction leading to the destruction of cancer cells.

After consulting a lot of data, we found that this compound(591-54-8)Recommanded Product: 4-Aminopyrimidine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Chang, Michael; Dufour, Suzie; Carlen, Peter L.; Valiante, Taufik A. researched the compound: 4-Aminopyrimidine( cas:591-54-8 ).Safety of 4-Aminopyrimidine.They published the article 《Generation and on-demand initiation of acute ictal activity in rodent and human tissue》 about this compound( cas:591-54-8 ) in Journal of Visualized Experiments. Keywords: seizure cortex optogenetics neurotransmitters. We’ll tell you more about this compound (cas:591-54-8).

Controlling seizures remains a challenging issue for the medical community. To make progress, researchers need a way to extensively study seizure dynamics and investigate its underlying mechanisms. Acute seizure models are convenient, offer the ability to perform electrophysiol. recordings, and can generate a large volume of electrog. seizure-like (ictal) events. The promising findings from acute seizure models can then be advanced to chronic epilepsy models and clin. trials. Thus, studying seizures in acute models that faithfully replicate the electrog. and dynamical signatures of a clin. seizure will be essential for making clin. relevant findings. Studying ictal events in acute seizure models prepared from human tissue is also important for making findings that are clin. relevant. The key focus in this paper is on the cortical 4-AP model due to its versatility in generating ictal events in both in vivo and in vitro studies, as well as in both mouse and human tissue. The methods in this paper will also describe an alternative method of seizure induction using the Zero-Mg2+ model and provide a detailed overview of the advantages and limitations of the epileptiform-like activity generated in the different acute seizure models. Moreover, by taking advantage of com. available optogenetic mouse strains, a brief (30 ms) light pulse can be used to trigger an ictal event identical to those occurring spontaneously. Similarly, 30 – 100 ms puffs of neurotransmitters (Gamma-Amino Butyric Acid or glutamate) can be applied to the human tissue to trigger ictal events that are identical to those occurring spontaneously. The ability to trigger ictal events on-demand in acute seizure models offers the newfound ability to observe the exact sequence of events that underlie seizure initiation dynamics and efficiently evaluate potential anti-seizure therapies.

After consulting a lot of data, we found that this compound(591-54-8)Safety of 4-Aminopyrimidine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and anticancer activity of novel Actinonin derivatives as HsPDF inhibitors, published in 2020-07-09, which mentions a compound: 591-54-8, mainly applied to peptidomimetic actinonin peptide synthesis antitumor structure activity HsPDF inhibitor; acyl chloride coupling chiral auxiliary alkylation bromoacetate oxidative hydrolysis; aromatic amine coupling proline nucleophilic addition nitrile hydroxylamine cyclization; amide amine peptide coupling hydrolysis Suzuki coupling mol docking; drug design target mechanism action, Related Products of 591-54-8.

Human mitochondrial peptide deformylase (HsPDF) is responsible for removing the formyl group from N-terminal formylmethionines of newly synthesized mitochondrial proteins and plays important roles in maintaining mitochondria function. It is overexpressed in various cancers and has been proposed as a novel therapeutic target. Actinonin, a naturally occurring peptidomimetic HsPDF inhibitor, was reported to inhibit the proliferation of a broad spectrum of human cancer cells in vitro. However, its efficacy and pharmacokinetic profile requires significant improvement for therapeutic purposes. To obtain HsPDF inhibitors as anticancer therapeutics, we screened an inhouse collection of actinonin derivatives and found two initial hits with antiproliferation activity. Further optimization along the peptidomimetic backbone lead to two series of compounds containing substituted Ph moieties. They are potent HsPDF inhibitors and exhibited greatly improved antiproliferation activity in selected cancer cell lines. Finally, compound (I) significantly inhibited the growth of human colon cancer in xenograft animal models.

Although many compounds look similar to this compound(591-54-8)Related Products of 591-54-8, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Aminopyrimidine( cas:591-54-8 ) is researched.Product Details of 591-54-8.Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas published the article 《Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis》 about this compound( cas:591-54-8 ) in Bioconjugate Chemistry. Keywords: palladium catalyzed hydroxycarbonylation heteroaryl halide DNA encoded library synthesis. Let’s learn more about this compound (cas:591-54-8).

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets.

Although many compounds look similar to this compound(591-54-8)Product Details of 591-54-8, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Study on hydrothermal liquefaction of spirulina platensis using biochar based catalysts to produce bio-oil, published in 2021-09-01, which mentions a compound: 591-54-8, Name is 4-Aminopyrimidine, Molecular C4H5N3, Recommanded Product: 591-54-8.

Hydrothermal liquefaction (HTL) is an effective conversion technol. of microalgae biomass. In this study, the low-lipid microalgae-spirulina platensis was used as feedstock to investigate the performance of the biochar-based catalysts on HTL. The byproduct of spirulina platensis HTL-solid residue was collected and activated to obtain the biochar (BC). Then, the BC was used as the carrier to support Co, Ni and their oxides CoOx and NiO to form Co/BC, Ni/BC, CoOx/BC, NiO/BC catalysts. The Response Surface Methodol. (RSM) was used to optimize the HTL parameters and investigate the effect of biochar-based catalysts on HTL. The results showed that the maximum yield of bio-oil catalyzed by BC was 35.80 wt% with 304 °C, 34.7 min, and 0.32 g catalyst loading. BC catalyst displayed an improvement of bio-oil yield up to 4.00 wt% at low temperatures (260-280 °C). Ni/BC was the most favorable catalyst for bio-oil production, reaching a maximum value of 36.57 wt% at 280 °C, 35.0 min, and 0.15 g catalyst loading, which increased by 6.40 wt% compared with the non catalytic case. The characterization of bio-oil showed that CoOx/BC and NiO/BC could raise the hydrocarbon content, H/C value, and heat value, while decrease O/C value. Ni/BC had an excellent denitrification effect on bio-oil, the N content was reduced by nearly 2.00 wt% compared with the non catalytic case.

Although many compounds look similar to this compound(591-54-8)Recommanded Product: 591-54-8, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Spletstoser, Jared T.; Dreabit, Jason; Knox, Andrew N.; Benowitz, Andrew; Campobasso, Nino; Ward, Paris; Cui, Guanglei; Lewandowski, Thomas; McCloskey, Lynn; Aubart, Kelly M. published an article about the compound: 4-Aminopyrimidine( cas:591-54-8,SMILESS:C1=CN=CN=C1N ).HPLC of Formula: 591-54-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:591-54-8) through the article.

The discovery of a novel series of peptide deformylase inhibitors incorporating a piperazic acid amino acid found in nature is described. These compounds demonstrated potent in vitro enzymic potency and antimicrobial activity. Crystal structure anal. revealed the piperazic acid optimized a key contact with the PDF protein that accounted for the increased enzymic potency of these compounds We describe lead optimization of the P3′ region of the series that resulted in a compound with good potency against three target organisms. One mol. showed in vivo efficacy in a rat respiratory infection model but ultimately did not meet candidate progression criteria.

Although many compounds look similar to this compound(591-54-8)HPLC of Formula: 591-54-8, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Bhuyar, Prakash; Sundararaju, Sathyavathi; Rahim, Mohd Hasbi Ab.; Unpaprom, Yuwalee; Maniam, Gaanty Pragas; Govindan, Natanamurugaraj published the article 《Antioxidative study of polysaccharides extracted from red (Kappaphycus alvarezii), green (Kappaphycus striatus) and brown (Padina gymnospora) marine macroalgae/seaweed》. Keywords: Kappaphycus Padina Gracilaria antioxidant polysaccharide.They researched the compound: 4-Aminopyrimidine( cas:591-54-8 ).Recommanded Product: 591-54-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:591-54-8) here.

Sterile and fresh tissues of three marine macroalgae red, green and brown (Kappaphycus alvarezii, Kappaphycus striatus and Padina gymnospora) collected from Malaysia east costal seas were compared for the antioxidants and polysaccharide composition of sugars as well as the active components. Results obtained showed that polysaccharides isolated from Kappaphycus alvarezii, Kappaphycus striatus and Padina gymnospora) can be used as a source of natural antioxidant compounds as they possess antioxidant potential in which the Padina gymnospora showed 15.56 ± 0.12 mg/mL to be the best antioxidants among all the polysaccharides studied. The hot water extraction method is effective in isolating polysaccharides from studied seaweeds. The GC-MS anal. revealed that there is presence of chem. compounds such as furfural was 25.53% in Kappaphycus alvarezii and 21.04% in Kappaphycus striatus also Padina gymnospora incorporates n- Hexadecanoic acid about 26.31% in seaweed polysaccharides that contribute to their antioxidant activities. Further studies can be done on determining the seaweed species that are available abundantly with the best source of natural antioxidant compounds

After consulting a lot of data, we found that this compound(591-54-8)Recommanded Product: 591-54-8 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 591-54-8, is researched, SMILESS is C1=CN=CN=C1N, Molecular C4H5N3Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Cu/N,N’-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines, Author is Chen, Zhixiang; Ma, Dawei, the main research direction is aryl halide heteroarylamine arylation copper oxalamide; diarylamine preparation; copper oxalamide arylation catalyst.Recommanded Product: 4-Aminopyrimidine.

N,N’-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For (hetero)aryl bromides/iodides, coupling reaction took place at 80-100 °C with 1 mol % CuI and 2 mol % DBO. A variety of heteroanilines worked well to afford the arylation products in good to excellent yields.

Although many compounds look similar to this compound(591-54-8)Recommanded Product: 4-Aminopyrimidine, numerous studies have shown that this compound(SMILES:C1=CN=CN=C1N), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem