Category: 566205-01-4

Meti, Puttavva published the artcile2,6-Di(thiophenyl)-1,5-dihydrodipyrrolopyrazine (DT-DPP) structural isomers as donor-acceptor-donor molecules and their optoelectronic investigation, Category: pyrazines, the main research area is dithiophenyl dihydrodipyrrolopyrazine preparation optoelectronic photophys thermal property.

Synthesis and characterization of two new D-A-D mols. 1,5-dimethyl-2,6-di(thiophen-2-yl)-1,5-dihyrodipyrrolo[3,2-b:3′,2′-e]pyrazine (2DT-DPP) and 1,5-dimethyl-2,6-di(thiophen-3-yl)-1,5-dihyrodipyrrolo[3,2-b:3′,2′-e]pyrazine (3DT-DPP) via Pd catalyzed C-C and C-N coupling reactions were reported. The dipyrrolopyrazine scaffold comprised an electron-accepting core flanked by twothiophene moieties. To reveal the mol. geometry and mol. packing of 3DT-DPP, X-ray single crystal anal. was carried out. The surface morphol. anal. showed the formation of microrods. The photophys. properties of these systems were characterized by UV-vis, fluorescence spectroscopy and cyclic voltammetry. The thermal properties reveal that both the isomers were thermally stable up to 300°. This study clearly demonstrated that compounds DT-DPPs were used to build D-A mols. to produce promising conjugated materials for various optoelectronic applications.

RSC Advances published new progress about Aggregates. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Category: pyrazines.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Hosoya, Takamitsu published the artcileConcise Synthesis of v-Coelenterazines, HPLC of Formula: 566205-01-4, the main research area is coelenterazine vinylene analog preparation luminescence Renilla luciferase substrate; vinylene coelenterazine preparation cross coupling ring closing metathesis.

A novel synthetic method for v-coelenterazine (v-CTZ), I (R = OH), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-coupling reactions and ring-closing metathesis (RCM). A newly synthesized C2-modified trifluoromethyl analog cf3-v-CTZ, I (R = CF3), showed slightly more red-shifted luminescence than v-CTZ when it was used as a substrate for Renilla luciferases.

Organic Letters published new progress about Bioluminescence. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, HPLC of Formula: 566205-01-4.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Meti, Puttavva published the artcileSelf-assembled organic microfibers and nanofibers of 2,6-diphenyl dihydrodipyrrolopyrazine (DP-DPP) derivatives for optoelectronic applications, COA of Formula: C4H2Br2ClN3, the main research area is self assembled microfiber nanofiber diphenyldihydrodipyrrolopyrazine derivative optoelectronics; crystal structure diphenyldihydrodipyrrolopyrazine derivative self assembled microfiber nanofiber.

Microfibers and nanofibers with promising application in optoelectronics are desirable in current material synthesis. A synthetic method has been developed for the preparation of dipyrrolopyrazine derivatives by employing palladium catalyzed Buchwald and Sonogashira coupling reactions. A comprehensive study on the synthesis, optical properties, thermal stability and morphol. of DP-DPP derivatives 8(a-d) was carried out. Surface morphol. anal. showed the formation of microfibers, square facets and nanorods. Electrochem. studies revealed HOMO energy levels at -5.10 to -5.88 eV and LUMO energy levels in the range -2.49 to -3.12 eV. All compounds exhibited a high degree of thermal stability and decomposition temperature of 322-372°. The enhanced air durability and thermal stability combined with good morphol. makes DPP as a promising candidate for optoelectronic application.

Tetrahedron published new progress about Crystal structure. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, COA of Formula: C4H2Br2ClN3.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Nie, Shenyou published the artcileSynthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease, Application In Synthesis of 566205-01-4, the main research area is allosteric inhibitor flavivirus NS2B NS3 protease.

Flaviviruses, including Zika, dengue, and West Nile viruses, are important human pathogens. The highly conserved NS2B-NS3 protease of Flavivirus is essential for viral replication and therefore a promising drug target. Through compound screening, followed by medicinal chem. studies, a novel series of 2,5,6-trisubstituted pyrazine compounds are found to be potent, allosteric inhibitors of Zika virus protease (ZVpro) with IC50 values as low as 130 nM. Their structure-activity relationships are discussed. The ZVpro inhibitors also inhibit homologous proteases of dengue and West Nile viruses, and their inhibitory activities are correlated. The most potent compounds 47 and 103 potently inhibited Zika virus replication in cells with EC68 values of 300-600 nM and in a mouse model of Zika infection. These compounds represent novel pharmacol. leads for drug development against Flavivirus infections.

Journal of Medicinal Chemistry published new progress about Allosteric modulators. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Application In Synthesis of 566205-01-4.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Meti, Puttavva published the artcileSynthesis of dipyrrolopyrazine-based sensitizers with a new π-bridge end-capped donor-acceptor framework for DSSCs: a combined experimental and theoretical investigation, Category: pyrazines, the main research area is dipyrrolopyrazine dye sensitized solar cell donor acceptor.

The strategy of developing organic dyes with exceptional optical, thermal, and stable photovoltaic properties has attracted substantial attention in the replacement of high-cost traditional dyes in DSSCs. Herein, we synthesized four dyes with a D-π-A configuration in order to study the variation produced in the optical, thermal, redox and photovoltaic properties by substitution of different donors and acceptors in the dipyrrolopyrazine (DPP) system. These push-pull systems are based on a pyrrolopyrazine spacer, end-capped with donors (N,N-dimethylamine, and thiophene) and acceptors (pyridine, -COOH, and -CN). The multidisciplinary study concerning the optical, thermal, redox, and photovoltaic characterization of the dyes reveals that compound 3a exhibits the best overall conversion efficiency as a sensitizer in TiO2 dye sensitized solar cells. The theor. calculations together with exptl. data allow us to quantify the charge transfer character of dyes.

New Journal of Chemistry published new progress about Dye-sensitized solar cells. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Category: pyrazines.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Meti, Puttavva published the artcileStructure property relationships of tunable donor-acceptor functionalized dipyrrolopyrazine derivative as selective reversible acid base sensor, Application In Synthesis of 566205-01-4, the main research area is structure property relationship tunable donor acceptor functionalized dipyrrolopyrazine derivative; selective reversible acid base sensor.

A practical approach towards the development of organic scaffold for material science application through substituent engineering of dipyrrolopyrazine (DPP) chromophore was introduced. The authors describe the synthesis and optoelectronic characterization of DPP-derivatives decorated with Donor and acceptor moieties. Tailoring of the optical properties in the desired direction can be achieved by differing electron donor and acceptor units attached at C-2 and C-6 position of DPP scaffold. The optical, thermal, and electrochem. properties were studied. Chromophores exhibit red shift in absorption and emission spectra upon treatment with TFA and also exhibit distinct self-assembly behavior. Morphol. characterizations indicate the formation of nanorods and microrods. Optical, thermal and morphol. studies indicate its potential application in sensors and other optoelectronic device.

Dyes and Pigments published new progress about Acids Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Application In Synthesis of 566205-01-4.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Nishiyama, Yoshitake published the artcileFacile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach, Application In Synthesis of 566205-01-4, the main research area is tetraarylpyrazine preparation; triarylpyrazine arylboronic acid cross coupling.

A facile synthetic method for unsym. tetraarylpyrazines I (R = 4-CH3C6H4, 2-naphthyl; R1 = 4-CF3C6H4, 4-(OTBS)C6H4, 4-NCC6H4; R2 = C6H5, 4-CH3OC6H4; R3 = 4-FC6H4, 4-N(CH3)2C6H4, 2-OHC6H4, 4-F3CC6H4, 4-N(C6H5)2C6H4) by sequential cross-couplings is disclosed. This 5-step synthesis was achieved from 2-amino-3,5-dibromo-6-chloropyrazine through four-fold cross-coupling and diazotization. Dibenzo-fused quinoxaline like 2-(4-methoxyphenyl)-7-methyl-3-(4-(trifluoromethyl)phenyl)dibenzo[f,h]quinoxaline synthesis was also accomplished by further intramol. coupling.

Chemistry Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Application In Synthesis of 566205-01-4.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Meti, Puttavva published the artcileSynthesis, characterization and optoelectronic properties of pyrrolopyrazine based Y-shaped color-tunable dipolar molecules, Category: pyrazines, the main research area is color tunable pyrrolopyrazine preparation thermal optoelectronic fluorescence.

A regioselective approach for the synthesis of functionalized dipolar Y-shaped chromophores is demonstrated. A series of dipolar pyrrolopyrazine based mols. were prepared in a straightforward manner. The key step in the preparation of the chromophores involves two-fold Sonogashira coupling reaction between the pyrrolopyrazine core and acetylene derivatives Different electron-donors, including, NH2, NMe2, OMe and CF3, CN acceptors were incorporated into the chromophores. By adjusting the substituents at 2, 3, and 6-position of the pyrrolopyrazine, dipolar tunable mols. with wide emission band are synthesized. The optical, thermal, and electrochem. properties of the materials are analyzed and the results are supported with the DFT calculations The preliminary studies of these engineered Y-shaped mols. indicate their potential as new building blocks in the fields of optoelectronic devices.

Dyes and Pigments published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Category: pyrazines.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Kwak, Se Hun published the artcileSynthesis of N-substituted 2-aminothiazolo[4,5-b]pyrazines by tandem reaction of o-aminohalopyrazines with isothiocyanates, Formula: C4H2Br2ClN3, the main research area is pyrazine thiazole preparation tandem reaction; chloro pyrazinamine cyclization isothiocyanate; bromo aminopyrazine cyclization isothiocyanate.

Under optimized reaction conditions, the synthesis of the target compounds was achieved by a sodium hydroxide-mediated tandem reaction of isothiocyanate derivatives with 3-halo-2-pyrazinamine. A reaction of isothiocyanate derivatives with 3-chloro-2-pyrazinamine derivatives gave N-(phenyl)thiazolo[4,5-b]pyrazin-2-amine (I) and related substances.

Bulletin of the Korean Chemical Society published new progress about Azoles Role: SPN (Synthetic Preparation), PREP (Preparation). 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Formula: C4H2Br2ClN3.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Meti, Puttavva published the artcileRegioselective synthesis of dipyrrolopyrazine (DPP) derivatives via metal free and metal catalyzed amination and investigation of their optical and thermal properties, Computed Properties of 566205-01-4, the main research area is dipyrrolopyrazine derivative preparation regioselective; dihalo pyrrolopyrazine alkyne metal catalyst amination reaction.

An efficient methods for the synthesis of dipyrrolopyrazine derivatives, I [R1 = H, C6H5; R2 = C6H5, 4-F-C6H4, (CH3)2NC6H4, cyclopropyl, etc.] and II and pyrrolothieno-pyrazine derivatives, III (X = H, C6H5) that involve regioselective amination reactions of dihalo-pyrrolopyrazines IV [Y = H, CH3, 4-CH3C6H4S(O)2; A = Br; B = Cl] is reported. The developed protocol readily affords either 2-amino- or 3-amino-pyrrolopyrazines IV (A = Br, NHCH3; B = Cl, NHCH3) from the corresponding 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines IV (A = Br; B = Cl). When the amination reactions was carried under metal-free microwave irradiation, 3-amino-pyrrolopyrazines IV (A = Br; B = NHCH3) was obtained exclusively. In contrast, Buchwald cross coupling of the 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines IV (A = Br; B = Cl) affords only 2-amino-pyrrolopyrazine IV (A = NHCH3; B = Cl). The pyrrolopyrazine scaffolds was converted to the resp. 1,7- I and 1,5-dihydrodipyrrolo[2,3-b]pyrazines derivatives II using Sonogashira reactions. A comprehensive study of the optical properties, thermal properties, and mol. packing of the synthesized compounds was carried out. The results indicate that the 1,7-derivatives I may be promising organic materials for optoelectronic applications.

RSC Advances published new progress about Amination. 566205-01-4 belongs to class pyrazines, name is 2-Amino-3,5-dibromo-6-chloropyrazine, and the molecular formula is C4H2Br2ClN3, Computed Properties of 566205-01-4.

Referemce:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem