Category: 56423-63-3

Application of 56423-63-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56423-63-3 as follows.

Under nitrogen atmosphere,4-nitrochlorobenzene (10 mg, 0.5 mmol),Potassium ethyl xanthate(80 mg, 0.5 mmol),N, N-dicarboximide (2 ml) was added to the dried reaction tube,The reaction was stirred for 2 h at 40 C in an oil bath.After the reaction system was cooled to room temperature,2-Bromopyrazine (80 mg, 0.5 mmol) was added to the reaction tube,Suspended in oil bath at 80 C for 12 h.After the reaction system was cooled,15 ml of 7K,The aqueous phase was extracted three times with 30 ml of ethyl acetate,The organic phases were combined,The solvent was evaporated under reduced pressure,Column chromatography gave a yellow solid(4-nitrophenyl)(2′ – pyrazinyl)Sulfide (lllmg, received95%).

According to the analysis of related databases, 56423-63-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yichun University; Zhu, Qiming; Yuan, Qinghe; Chen, Ye; (9 pag.)CN105218418; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56423-63-3, name is 2-Bromopyrazine, This compound has unique chemical properties. The synthetic route is as follows., 56423-63-3

Preparation 133 2-Chloro-4-(pyrazin-2-yl)aniline To a mixture of 4-amino-3-chlorophenylboronic acid pinacol ester (0.110 g, 0.434 mmol), 2-bromopyrazine (0.090 g, 0.56 mmol), 1,1′-bis(diphenylphosphino)ferrocene)-dichloropalladium(II) DCM complex (24 mg, 0.029 mmol) was added anhydrous DME (3.0 mL) followed by 2M aqueous sodium carbonate (0.53 mL, 1.06 mmol). The microwave vial was heated at 75 C. for 40 minutes under microwave irradiation. Further catalyst (0.012 g) was added and the vial was heated at 90 C. for 25 minutes under microwave irradiation. Further 2-bromopyrazine (0.060 g), catalyst (12 mg) and 2M aqueous sodium carbonate (0.25 mL) were added and the reaction mixture was heated at 90 C. for an additional 30 minutes under microwave irradiation. The reaction was partitioned between ethyl acetate (60 mL) and a saturated aqueous NaHCO3 solution (15 mL). The organic layer was washed with a saturated aqueous NaHCO3 solution (2*15 mL), dried (Na2SO4) and concentrated in vacuo. The residue was purified using preparative TLC eluting with 7% ethyl acetate in CH2Cl2. The product band was recovered and stirred with 2% MeOH in ethyl acetate/CH2Cl2 (v/v; 1:10) (20 mL). The silica was removed by filtration, washed with ethyl acetate/CH2Cl2 (v/v; 1:5) (2*5 mL) and acetone (3*4 mL) to give the title compound as an off-white solid (0.039 g, 44%). 1H-NMR (500 MHz, DMSO-d6) 5.86 (s, 2H), 6.89 (d, J=8.5, 1H), 7.85 (dd, J=2.1, 8.5 Hz, 1H), 8.02 (d, J=2.1 Hz, 1H), 8.44 (d, J=2.5 Hz, 1H), 8.57 (dd, J=1.6, 2.5 Hz, 1H), 9.12 (d, J=1.5 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; Bavetsias, Vassilios; Atrash, Butrus; Naud, Sebastien Gaston Andre; Sheldrake, Peter William; Blagg, Julian; US2013/345181; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., 56423-63-3

To a stirred solution of 2-bromopyrazin (500mg, 3. immol) in dioxan (5mL) were added N({ 2- [(3- { [(tert-butyldimethylsilyl)oxy] methyl }pyridin-2-yl) sulfanyl] -3-chloro-5-(4,4,5 ,5 – tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenyl } methyl)-2-methylpropane-2-sulfinamide (2.3 g, 3.7mmol), Na2CO3 (1.Og ,9.4mmol), water (2mL) and degassed for 10 mm in argon atmosphere. Then to it was added Pd(PPh3)4 (363mg, 0.3 lmmol) and again degassed for 5 mm. The reactionmass was heated to 120C for 16 h. Reaction mixture was then cooled to 25C, filtered through celite pad and washed with EtOAc. The separated organic layer was washed with brine solution, dried over sodium sulfate and concentrated under reduced pressure. The crude thus obtained was purified by normal silica column using 0-10% methanol in DCM to get N-({2-[(3-{[(tert-butyldimethylsilyl)oxy] methyl }pyridin-2-yl) sulfanyl] -3-chloro-5- (pyrazin-2-yl)phenyl I methyl)2-methylpropane-2-sulfinamide (450mg) as off white solid. LC-MS: 577.1 [M+H] +

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALANINE, Alexander; BEIGNET, Julien; BLEICHER, Konrad; FASCHING, Bernhard; HILPERT, Hans; HU, Taishan; MACDONALD, Dwight; JACKSON, Stephen; KOLCZEWSKI, Sabine; KROLL, Carsten; SCHAEUBLIN, Adrian; SHEN, Hong; STOLL, Theodor; THOMAS, Helmut; WAHHAB, Amal; ZAMPALONI, Claudia; (623 pag.)WO2017/72062; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

56423-63-3, Adding a certain compound to certain chemical reactions, such as: 56423-63-3, name is 2-Bromopyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56423-63-3.

To a solution of Compound 18 (40 mg) in DMF (1.0 ml), NaH (5.2 mg, >55% in minerai oil) was added and after stirring for 30 minutes, 2-bromopyrazine (23.8 mg) was added and the mixture was stirred at room temperature for 0.5 hour. [0220] To the reaction mixture, DMSO (1.0 ml) was added and after filtering off the insoluble matter, the filtrate was purified by reverse-phase preparative HPLC to give the titled compound (6.7 mg, colorless oil.) 1H NMR (600MHz, CHLOROFORM-d) delta 8.34 – 8.29 (m, 1 H), 8.24 – 8.18 (m, 1 H), 8.13 – 8.08 (m, 1 H), 6.28 [6.19] (s, 1 H), 5.60 – 5.36 (m, 3 H), 4.24 – 4.13 (m, 1 H), 3.95 – 3.87 (m, 1 H), 3.82 – 3.69 (m, 1 H), 2.35 – 0.76 (m, 22 H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromopyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; ONO, Naoya; KURODA, Shoichi; SHIRASAKI, Yoshihisa; TAKAYAMA, Tetsuo; SEKIGUCHI, Yoshinori; USHIYAMA, Fumihito; OKA, Yusuke; EP2687524; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem