Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54126-45-3, name is 3-Chloro-N,N-dimethylpyrazin-2-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 54126-45-3
(2b) 47 g of 2-chloro-3-dimethylamino-pyrazine and 35 g of allyl alcohol are dissolved in 300 ml of hexamethylphosphoric acid triamide. 14.4 g of sodium hydride are introduced into this solution at 0 C. over the course of 30 minutes. The mixture is then stirred for a further hour at 0 C. and for 15 hours at room temperature. The reaction mixture is then poured into 2 liters of ice water. After excess sodium hydride has been decomposed, the mixture is extracted by shaking with ether. The ether extracts are washed with water until neutral, dried over sodium sulphate and evaporated in a waterpump vacuum. The residue is distilled under reduced pressure. 2-Allyloxy-3-dimethylamino-pyrazine, boiling point 110-115 C./10 mm Hg, is thus obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Ciba-Geigy Corporation; US4115575; (1978); A;; ; Patent; Ciba-Geigy Corporation; US4410530; (1983); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem